Dr. Tammy Dugas
Comparative Biomedical Sciences (CBS)
Dr. Dugas received her Ph.D in Chemistry from LSU and went on to complete two postdoctoral fellowships, one in Biochemistry at Drexel University College of Medicine in Philadelphia, PA, and one in Toxicology at the University of Texas Medical Branch in Galveston. Dr. Dugas spent 13 years as a faculty member conducting research at the LSU Health Sciences Center in Shreveport before re-locating to the LSU School of Veterinary Medicine in 2014. Her research interests are generally in the area of cardiovascular pharmacology and toxicology.
Veterinary Pharmacology (VMED 5223), Environmental Toxicology
Our toxicological research focuses on the role of the environment and environmental factors in the induction or exacerbation of vascular diseases including atherosclerosis and pulmonary hypertension. In particular, we are investigating the vascular toxicity of airborne particulate matter, of aromatic amines, compounds used industrially in the production of polyurethanes, and of HIV antiretroviral drug therapies. Mechanistic studies aimed at elucidating these toxicities explore drug/toxicant metabolism, endothelial cell injury (including mitochondrial oxidant stress), and stimulation of vascular smooth muscle cell proliferation. We furthermore explore the role of gender in determining the outcome of these vascular toxicities. In other toxicological studies, we are examining the potential for combustion-generated ultrafine particulate matter (PM) to produce reactive oxygen species and induce oxidative stress in rodents exposed by inhalation. Finally, in our pharmacological studies, we are elucidating pathways by which red wine polyphenols might act on the estrogen receptor so as to promote vascular homeostasis and prevent the development of vascular diseases including atherosclerosis and restenosis.