Dr. Tammy Dugas
Comparative Biomedical Sciences (CBS)

Biography:
Dr. Dugas received her Ph.D in Chemistry from LSU and went on to complete two postdoctoral fellowships, one in Biochemistry at Drexel University College of Medicine in Philadelphia, PA, and one in Toxicology at the University of Texas Medical Branch in Galveston. Dr. Dugas spent 13 years as a faculty member conducting research at the LSU Health Sciences Center in Shreveport before re-locating to the LSU School of Veterinary Medicine in 2014. Her research interests are generally in the area of cardiovascular pharmacology and toxicology.

Teaching Interests:
Veterinary Pharmacology (VMED 5223), Environmental Toxicology

Research Interests:
Our toxicological research focuses on the role of the environment and environmental factors in the induction or exacerbation of vascular diseases including atherosclerosis and pulmonary hypertension. In particular, we are investigating the vascular toxicity of airborne particulate matter, of aromatic amines, compounds used industrially in the production of polyurethanes, and of HIV antiretroviral drug therapies. Mechanistic studies aimed at elucidating these toxicities explore drug/toxicant metabolism, endothelial cell injury (including mitochondrial oxidant stress), and stimulation of vascular smooth muscle cell proliferation. We furthermore explore the role of gender in determining the outcome of these vascular toxicities. In other toxicological studies, we are examining the potential for combustion-generated ultrafine particulate matter (PM) to produce reactive oxygen species and induce oxidative stress in rodents exposed by inhalation. Finally, in our pharmacological studies, we are elucidating pathways by which red wine polyphenols might act on the estrogen receptor so as to promote vascular homeostasis and prevent the development of vascular diseases including atherosclerosis and restenosis.

 Awards & Honors:
  • 2018 Dean's Teacher Merit Honor Roll
  • 2016 Co-chair, CME Workshop: “Breaking Bad”—Cardiovascular Autophagy Gone Rogue: A Putative Mechanism of Toxicity and a Drug Target in Disease
  • 2016 Distinguished Research Scholar Award
  • 2015 Invited Professor
 Grants:
  • Pharmacokinetics of ligustilide from the Chinese herb Dang Gui, Radix Angelicae sinesis, after a single-dose oral administration in the American alligator (Alligator mississippiensis)., VCS Corps Grant, $5,000.00
  • Pharmacokinetics of ligustilide from the Chinese herb Dang Gui, Radix Angelicae sinesis, after a single-dose oral administration in the American alligator (Alligator mississippiensis)., Dr. Xie's Jing Tang Herbal Co, $500.00
  • Nanoparticles for sustained release of drug designed to reduce vascular smooth muscle cell proliferation while promoting re-endothelialization, Louisiana Board of Regent ITRS Program, $200,495.00
  • Novel toxicant induced model for female specific pulmonary arterial hypertension, American Heart Association, $82,500.00
  • NIEHS, National Institutes of Health, $143,715.00
  • Cardio-pulmonary responses in mice following inhalation exposure to environmentally persistent free radicals, Louisiana Biomedical Collaborative Research Program (LSUHSC and LSU), $50,000.00
  • NHLBI, National Institutes of Health, $67,500.00
  • NHLBI, National Institutes of Health, $25,000.00
 Publications:
Journal Article, Professional Journal:
  • Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor, Jaligama, Sridhar; Patel, Vivek; Wang, Pingli; Sallam, Asmaa; Harding, Jeffrey; Kelley, Matthew; Mancuso, Skylar; Dugas, Tammy; Cormier, Stephania, 2018, Particle & Fibre Toxicology , Volume: 15, Number: 1, Pages: 20
  • Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease, Dugas, Tammy, 2018, Current Opinion in Toxicology , Volume: 7, Pages: 1-8
  • Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals, Dugas, Tammy; Lomnicki, Slawomir; Cormier, Stephania; Reams, Margaret, 2016, Int J Environ Res Public Health , Volume: 13, Number: 6, Pages: 573
  • Enhanced systemic bioavailability of curcumin through transmucosal administration of a novel microgranular formulation., Latimer, Brian; Ekshyyan, Oleander; Nathan, Neil; Moore-Medlin, Tara; Khandelwal, Alok; Abreo, Fluorette; McClure, Gloria; Vanchiere, John; Caldito, Gloria; Dugas, Tammy; McMartin, Kenneth; Lian, Timothy; Nathan, Cherie-Ann, 2015, Anticancer Research , Volume: 35, Number: 12, Pages: 6411-8
  • 4,4'-methylenedianiline alters serotonergic transport in a novel, sex-specific model of pulmonary arterial hypertension in rats, Dugas, Tammy; Carroll-Turpin, M; Hebert, V; Chotibut, T; Wensler, H; Krentzel, D; Varner, K; Burn, B; Chen, Y, 2015, Toxicol. Sci.
  • Exposure to Deepwater Horizon crude oil burn-off particulate matter induces pulmonary inflammation and alters adaptive immune response., Dugas, Tammy; Jaligama, S; Chen, Z; Saravia, J; Yadav, N; Lomnicki, S; Cormier, S, 2015, Environ. Sci.Technol.
  • Hydrogen sulfide measurement using sulfide dibimane: critical evaluation with electrospray ion trap mass spectrometry, Dugas, Tammy; Shen, X; Chakraborty, S; Kevil, C, 2015, Nitric Oxide , Volume: 41, Pages: 97-104
  • Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection, Dugas, Tammy; Lee, G; Saravia, J; You, D; Shrestha, B; Jaligama, S; Hebert, V; Cormier, S, 2014, Particle Fibre Toxicol. , Volume: 11, Number: 57
  • Overexpression of MnSOD provides protection against NRTI-induced endothelial dysfunction., Dugas, Tammy; Glover, M; Hebert, V; Nichols, K; Xue, S; Thibeaux, T; Zavecz, J, 2014, Antiviral Res , Volume: 111, Pages: 136-142
Book, Textbook:
  • HIV-1 infection, antiretroviral therapies and HIV-associated atherosclerosis., Dugas, Tammy; Glover, M, 2015