Dr. Sonika Patial
Assistant Professor
Comparative Biomedical Sciences (CBS)

Biography:
Dr. Patial received her DVM (1998-2003) from College of Veterinary and Animal Sciences, Palampur (India) and MVSc (2003-2005) from Indian Veterinary Research Institute, Izatnagar (India). She received her PhD (Cell and Molecular Biology) from Michigan State University in 2010. Thereafter, she completed her postdoctoral fellowship (2011-2016) at The National Institute of Environmental Health Sciences, North Carolina; and residency in Veterinary Anatomic Pathology. Dr. Patial Joined LSU as an Assistant Professor in 2017. Dr. Patial is a Diplomate of American College of Veterinary Pathologists (ACVP).

Teaching Interests:
Microscopic Anatomy (VMED 5132)
Problem Based Learning (PBL 5001)
Biomedical Cell and Molecular Biology (CBS 7103)
Molecular and Cellular Mechanisms of Host Responses to Infection (PBS 7003)

Research Interests:
Post-transcriptional Regulation of Gene Expression in Inflammation, hepatotoxicity, and Cancer

Innate immunity is a highly conserved response that quickly detects and attempts to clear pathogens and harmful environmental stimuli by inducing inflammatory responses. These responses are orchestrated via temporal and highly coordinated regulation of a number of genes. In addition to regulation at the transcriptional level, a majority of these genes are also regulated by post-transcriptional mechanisms that modify mRNA stability and/or translation. The focus of our research is to understand the association between environmental stimuli, post-transcriptional mechanisms of gene expression, and disease pathogenesis. We are specifically interested in:

1) Investigating how post-transcriptional mechanisms of gene expression regulate the pathogenesis of acute lung injury/acute respiratory distress syndrome.

2) Understanding the biochemical mechanisms of hepatotoxicity and carcinogenesis in the context of post-transcriptional regulation of gene expression.

Training Positions Available
Positions are available for motivated, research career-oriented undergraduate, graduate, and postdoctoral trainees. Interested candidates may email their CVs to spatial@lsu.edu

Contact
E-mail: spatial@lsu.edu
Phone: 225-578-9884
Office: 2518 VetMed
Lab: 2503, 2547 VetMed

 Awards & Honors:
  • 2020 Hans Monga Faculty Award (ASIP/EB 2020)
  • 2020 Dean's Teacher Merit Honor Roll (Class of 2023)
  • 2019 ACVP Diplomate
  • 2019 Dean's Teacher Merit Honor Roll (Class of 2022)
  • 2019 Highest Scoring Teacher by Year 1 (DVM Curriculum)
  • 2019 Poster Presentation Award (Post Doctoral Fellow)
  • 2018 Dean's Teacher Merit Honor Roll (Class of 2021)
  • 2018 AAI Early Career Faculty Travel Grant
  • 2017 Early Career Investigator Award (Liver Cancer Conference)
  • 2016 NIEHS/NIH Paper of the Year
  • 2016 NIEHS Paper of the Month, June
  • 2016 Abstract Award (Society of Toxicologic Pathology)
  • 2016 NIEHS Paper of the Month, April
  • 2015 Best Poster Award (13th Annual Science Day, NIEHS)
  • 2015 Travel Award (13th Annual Science Day, NIEHS)
  • 2015 Best Poster Award (Symposium on RNA Biology, XI, Duke University)
  • 2015 Fellows Award for Research Excellence (NIH)
  • 2015 Travel Award (NIH)
  • 2015 Abstract Award (ASBMB, EB meeting)
  • 2010 Dissertation Completion Fellowship (MSU)
  • 2010 Travel Award (Graduate School, MSU)
  • 2009 Travel Award (College of Natural Sciences, MSU)
  • 2005 Distinction Award (MS, Indian Veterinary Research Institute)
 Education:
  • Diplomate, American College of Veterinary Pathologists (DACVP)
  • PhD, Michigan State University
  • MS, Indian Veterinary Research Institute (IVRI)
  • DVM, College of Veterinary and Animal Sciences, CSK HP Agricultural University
 Grants:
  • Understanding Myeloid Signaling in Ozone Induced Lung Diseases (2019-2024), R01, $2,672,000.00
  • Role of mTOR and its targeting by fisetin for treating psoriasis, NIGMS (INBRE-COBRE), $155,800.00
  • Tristetraprolin and Acute Lung Injury, NIGMS (INBRE-COBRE), $10,000.00
  • Modulation of lung inflammation by tristetraprolin, COBRE NIGMS P20GM130555-01, $825,000.00
  • Interplay of tristetraprolin, chronic inflammation, and microbiome in the pathogenesis of inflammatory bowel disease, Louisiana Board of Regents LEQSF (2018-21)-RD-A-06/ Research Competitiveness Subprogram, $126,453.00
  • Modulation of systemic inflammation by tristetraprolin, Pilot Project (COBRE) 5P30GM110760, $50,000.00
 Publications:
Journal Article, Professional Journal:
  • Immunopathology of Airway Surface Liquid Dehydration Disease, Patial, Sonika; Lewis, Brandon; Saini, Yogesh, 2019, Journal of Immunological Research , Volume: 11, Number: 1, Pages: 1
Journal Article, Academic Journal:
  • Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model, Lewis, Brandon ; Vo, Thao; Choudhary, Ishita ; Kidder, Allison ; Bathula, Chandra ; Ehre, Camille ; Wakamatsu, Nobuko; Patial, Sonika; Saini, Yogesh, 2020, The Journal of Immunology
  • The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma., Patial, Sonika, 2019, Cancers (Basel) , Volume: 11, Number: 11
  • Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease, Lewis, B; Sultana, R; Sharma, R; Noel, Alexandra; Langohr, Ingeborg; Patial, Sonika; Penn, Arthur; Saini, Yogesh, 2017, Journal of Immunology , Volume: 199, Number: 3, Pages: 1170-1183
  • Tristetraprolin as a Therapeutic Target in Inflammatory Disease., Patial, Sonika; Blackshear, P, 2016, Trends in pharmacological sciences , Volume: 37, Number: 10, Pages: 811-821.
  • Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies., Patial, Sonika; Curtis, 2nd, A; Lai, W; Stumpo, D; Hill, G; Flake, G; Mannie, M; Blackshear, P, 2016, Proceedings of the National Academy of Sciences of the United States of America , Volume: 113, Number: 7, Pages: 1865-70
  • mTOR regulates cellular iron homeostasis through tristetraprolin., Bayeva, M; Khechaduri, A; Puig, S; Chang, H; Patial, Sonika; Blackshear, P; Ardehali, H, 2012, Cell metabolism , Volume: 16, Number: 5, Pages: 645-57
  • G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice., Patial, Sonika; Shahi, S; Saini, Yogesh; Lee, T; Packiriswamy, N; Appledorn, D; Lapres, J; Amalfitano, A; Parameswaran, N, 2011, Journal of cellular physiology , Volume: 226, Number: 5, Pages: 1323-33
  • Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice., Patial, Sonika; Saini, Yogesh; Parvataneni, S; Appledorn, D; Dorn, 2nd, G; Lapres, J; Amalfitano, A; Senagore, P; Parameswaran, N, 2011, Journal of cellular physiology , Volume: 226, Number: 3, Pages: 627-37
  • Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation., Saini, Yogesh; Greenwood, K; Merrill, C; Kim, K; Patial, Sonika; Parameswaran, N; Harkema, J; LaPres, J, 2010, Toxicological sciences : an official journal of the Society of Toxicology , Volume: 116, Number: 2, Pages: 673-81
  • Tumor necrosis factor-α signaling in macrophages., Parameswaran, N; Patial, Sonika, 2010, Critical reviews in eukaryotic gene expression , Volume: 20, Number: 2, Pages: 87-103