Dr. Sonika Patial
Assistant Professor
Comparative Biomedical Sciences (CBS)

Dr. Patial received her DVM (1998-2003) from College of Veterinary and Animal Sciences, Palampur (India) and MVSc (2003-2005) from Indian Veterinary Research Institute, Izatnagar (India). She received her PhD (Cell and Molecular Biology) from Michigan State University in 2010. Thereafter, she completed her postdoctoral fellowship (2011-2016) at The National Institute of Environmental Health Sciences, North Carolina; and residency in Veterinary Anatomic Pathology. Dr. Patial Joined LSU as an Assistant Professor in 2017. Dr. Patial is a Diplomate of American College of Veterinary Pathologists (ACVP).

Teaching Interests:
Developmental and Microscopic Anatomy (VMED 5127)
Problem Based Learning (PBL 5001)
Biomedical Cell and Molecular Biology (CBS 7103)
Molecular and Cellular Mechanisms of Host Responses to Infection (PBS 7003)

Research Interests:
Post-transcriptional Regulation of Gene Expression in Innate Immunity, Inflammation, and Cancer

Innate immunity is a highly conserved response that quickly detects and attempts to clear pathogens and harmful environmental stimuli by inducing inflammatory responses. These responses are orchestrated via temporal and highly coordinated regulation of a number of genes. In addition to regulation at the transcriptional level, a majority of these genes are also regulated by post-transcriptional mechanisms that modify mRNA stability and/or translation. The focus of our research is to understand the association between environmental stimuli, post-transcriptional mechanisms of gene expression, and disease pathogenesis. We are specifically interested in: 1) understanding how environmental exposures affect post-transcriptional mechanisms, in order to cause inflammation and immune-mediated disease; 2) understanding how post-transcriptional mechanisms induce changes in gene expression that confer a competitive advantage to cancerous cells and contribute to tumor development.

Training Positions Available

Positions are available for motivated, research career-oriented undergraduate, graduate, and postdoctoral trainees. Interested candidates may email their CVs to spatial@lsu.edu


E-mail: spatial@lsu.edu

Phone: 225-578-9884

Office: 2518 VetMed

Lab: 2503, 2547 VetMed

 Awards & Honors:
  • 2020 Junior Faculty Award (ASIP/EB 2020)
  • 2020 Dean's Teacher Merit Honor Roll (Class of 2023)
  • 2019 ACVP Diplomate
  • 2019 Dean's Teacher Merit Honor Roll (Class of 2022)
  • 2019 Highest Scoring Teacher by Year 1 (DVM Curriculum)
  • 2019 Poster Presentation Award (Post Doctoral Fellow)
  • 2018 Dean's Teacher Merit Honor Roll (Class of 2021)
  • 2018 AAI Early Career Faculty Travel Grant
  • 2017 Early Career Investigator Award (Liver Cancer Conference)
  • 2016 NIEHS/NIH Paper of the Year
  • 2016 NIEHS Paper of the Month, June
  • 2016 Abstract Award (Society of Toxicologic Pathology)
  • 2016 NIEHS Paper of the Month, April
  • 2015 Best Poster Award (13th Annual Science Day, NIEHS)
  • 2015 Travel Award (13th Annual Science Day, NIEHS)
  • 2015 Best Poster Award (Symposium on RNA Biology, XI, Duke University)
  • 2015 Fellows Award for Research Excellence (NIH)
  • 2015 Travel Award (NIH)
  • 2015 Abstract Award (ASBMB, EB meeting)
  • 2010 Dissertation Completion Fellowship (MSU)
  • 2010 Travel Award (Graduate School, MSU)
  • 2009 Travel Award (College of Natural Sciences, MSU)
  • 2005 Distinction Award (MS, Indian Veterinary Research Institute)
  • Diplomate, American College of Veterinary Pathologists (DACVP)
  • PhD, Michigan State University
  • MS, Indian Veterinary Research Institute (IVRI)
  • DVM, College of Veterinary and Animal Sciences, CSK HP Agricultural University
  • Understanding Myeloid Signaling in Ozone Induced Lung Diseases (2019-2024), R01, $2,672,000.00
  • Role of mTOR and its targeting by fisetin for treating psoriasis, NIGMS (INBRE-COBRE), $59,200.00
  • Tristetraprolin and Acute Lung Injury, NIGMS (INBRE-COBRE), $10,000.00
  • Modulation of lung inflammation by tristetraprolin, COBRE NIGMS P20GM130555-01, $825,000.00
  • Interplay of tristetraprolin, chronic inflammation, and microbiome in the pathogenesis of inflammatory bowel disease, Louisiana Board of Regents LEQSF (2018-21)-RD-A-06/ Research Competitiveness Subprogram, $126,453.00
  • Modulation of systemic inflammation by tristetraprolin, Pilot Project (COBRE) 5P30GM110760, $50,000.00
Journal Article, Professional Journal:
  • Immunopathology of Airway Surface Liquid Dehydration Disease, Patial, Sonika; Lewis, Brandon; Saini, Yogesh, 2019, Journal of Immunological Research , Volume: 11, Number: 1, Pages: 1
Journal Article, Academic Journal:
  • Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model, Lewis, Brandon ; Vo, Thao; Choudhary, Ishita ; Kidder, Allison ; Bathula, Chandra ; Ehre, Camille ; Wakamatsu, Nobuko; Patial, Sonika; Saini, Yogesh, 2020, The Journal of Immunology
  • The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma., Patial, Sonika, 2019, Cancers (Basel) , Volume: 11, Number: 11
  • Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease, Lewis, B; Sultana, R; Sharma, R; Noel, Alexandra; Langohr, Ingeborg; Patial, Sonika; Penn, Arthur; Saini, Yogesh, 2017, Journal of Immunology , Volume: 199, Number: 3, Pages: 1170-1183
  • Tristetraprolin as a Therapeutic Target in Inflammatory Disease., Patial, Sonika; Blackshear, P, 2016, Trends in pharmacological sciences , Volume: 37, Number: 10, Pages: 811-821.
  • Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies., Patial, Sonika; Curtis, 2nd, A; Lai, W; Stumpo, D; Hill, G; Flake, G; Mannie, M; Blackshear, P, 2016, Proceedings of the National Academy of Sciences of the United States of America , Volume: 113, Number: 7, Pages: 1865-70
  • mTOR regulates cellular iron homeostasis through tristetraprolin., Bayeva, M; Khechaduri, A; Puig, S; Chang, H; Patial, Sonika; Blackshear, P; Ardehali, H, 2012, Cell metabolism , Volume: 16, Number: 5, Pages: 645-57
  • G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice., Patial, Sonika; Shahi, S; Saini, Yogesh; Lee, T; Packiriswamy, N; Appledorn, D; Lapres, J; Amalfitano, A; Parameswaran, N, 2011, Journal of cellular physiology , Volume: 226, Number: 5, Pages: 1323-33
  • Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice., Patial, Sonika; Saini, Yogesh; Parvataneni, S; Appledorn, D; Dorn, 2nd, G; Lapres, J; Amalfitano, A; Senagore, P; Parameswaran, N, 2011, Journal of cellular physiology , Volume: 226, Number: 3, Pages: 627-37
  • Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation., Saini, Yogesh; Greenwood, K; Merrill, C; Kim, K; Patial, Sonika; Parameswaran, N; Harkema, J; LaPres, J, 2010, Toxicological sciences : an official journal of the Society of Toxicology , Volume: 116, Number: 2, Pages: 673-81
  • Tumor necrosis factor-α signaling in macrophages., Parameswaran, N; Patial, Sonika, 2010, Critical reviews in eukaryotic gene expression , Volume: 20, Number: 2, Pages: 87-103