Dr. Shisheng Li
Professor
Comparative Biomedical Sciences (CBS)

Teaching Interests:
Biochemistry, cell and molecular biology, physiology.

Research Interests:
DNA damage repair and mutagenesis

 Awards & Honors:
  • 2019 Dean's Teacher Merit Honor Roll
  • 2018 Dean's Teacher Merit Honor Roll
  • 2017 Dean's Teacher Merit Honor Roll
  • 2015 Faculty distinguished scholar award
  • 2009 Pfizer award for research excellence
 Education:
  • PhD University of Wales, Swansea
  • MSc Nankai University
  • BS Henan Normal University
 Grants:
  • Molecular basis for the loss of differentiation capability in human bone marrow stem cells during expansion , National Institutes of Health, $350,812.00
  • Regulation of Transcription Coupled DNA Repair (TCR), Louisiana State University, $685,023.00
  • The role of Sen1 in transcription coupled DNA repair (TCR), NSF, $550,000.00
  • Dot1 and histone H3 K79 methylation in nucleotide excision repair, NSF, $642,444.00
  • DNA damage and repair in human melanocytes: relation to melanomagenesis mutations, NIH (R15), $457,962.00
  • High-throughput high-resolution mapping of DNA damage and repair in human cells., NIH (R03), $148,000.00
 Publications:
Journal Article, Academic Journal:
  • Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability, Geijer, M. E.; Zhou, D.; Selvam, K.; Steurer, B.; Mukherjee, C.; Evers, B.; Cugusi, S.; van Toorn, M.; van der Woude, M.; Janssens, R.; Kok, Y. P.; Gong, W.; Raams, A.; Lo, C.; Lebbink, J. H. G.; Geverts, B.; Plummer, D. A.; Bezstarosti, K.; Theil, A. F.; Mitter, R.; Houtsmuller, A. B.; Vermeulen, W.; Demmers, J. A. A.; Li, S.; van Vugt, M. A. T. M.; Lans, H.; Bernards, R.; Svejstrup, J. Q.; Chaudhuri, A. R.; Wyrick, J. J.; Marteijn, J. A., 2021, Nature Cell Biology , Volume: 23, Pages: 608–619
  • Histone H4 LRS mutations can attenuate UV mutagenesis without affecting PCNA ubiquitination or sumoylation, Selvam, K.; Rahman, S.; Forrester, D.; Bao, A.; Lieu, M.; Li, S., 2020, DNA Repair , Volume: 95, Pages: 102959
  • Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression, Ko, T.; Sharma, R.; Li, S., 2020, Oncogene , Volume: 39, Pages: 723–738
  • Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance, Ko, T.; Li, S., 2019, FASEB J. , Volume: 33, Pages: 7143-7154
  • Histone H4 H75E mutation attenuates global genomic and Rad26-independent transcription-coupled nucleotide excision repair, Selvam, K.; Rahman, S.; Li, S., 2019, Nucleic Acids Res. , Volume: 47, Pages: 7392-7401
  • Evidence that moderate eviction of Spt5 and promotion of error-free transcriptional bypass by Rad26 facilitates transcription coupled nucleotide excision repair, Selvam, K.; Ding, B.; Sharma, R.; Li, S., 2019, J. Mol. Biol. , Volume: 431, Pages: 1322-1338
  • Facilitators and Repressors of Transcription Coupled DNA Repair in Saccharomyces cerevisiae, Li, W.; Li, S., 2017, Photochem. Photobiol. , Volume: 93, Pages: 259–267
  • Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repair , Li, W.; Selvam, K.; Rahman, S.; Li, S., 2016, Nucleic Acids Res. , Volume: 44, Pages: 6794-6802
  • Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: the ambiguous role of Rad26, Li, S., 2015, DNA Repair , Volume: 36, Pages: 43-48
  • High-resolution digital mapping of N-methylpurines in human cells reveals modulation of their induction and repair by nearest-neighbor nucleotides, Li, M.; Ko, T.; Li, S., 2015, J. Biol. Chem. , Volume: 290, Pages: 23148-23161
  • Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair, Li, W.; Selvam, K.; Ko, T.; Li, S., 2014, Nucleic Acids Res. , Volume: 42, Pages: 13242-13253
  • Insights into how Spt5 functions in transcription elongation and repressing transcription coupled DNA repair, Li, W.; Giles, C.; Li, S., 2014, Nucleic Acids Res. , Volume: 42, Pages: 7069-7083
  • Implication of posttranslational histone modifications in nucleotide excision repair, Li, S., 2012, Int. J. Mol. Sci. , Volume: 13, Pages: 12461-12486
  • Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair, Tatum, D.; Li, W.; Placer, M.; Li, S., 2011, J. Biol. Chem. , Volume: 286, Pages: 30304-30313
  • Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79., Tatum, D.; Li, S., 2011, J. Biol. Chem. , Volume: 286, Pages: 17530-17535
  • N-methylpurines are heterogeneously repaired in human mitochondria but not evidently repaired in yeast mitochondria., Li, S., 2011, DNA Repair , Volume: 10, Pages: 65-72
  • The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair., Li, B.; LeJeune, D.; Li, S., 2010, J. Biol. Chem. , Volume: 285, Pages: 5317-5326
Book, Textbook Chapter:
  • Nucleotide Excision Repair in S. cerevisiae, Tatum, D.; Li, S., 2011, Publisher: InTech Open Access Publisher, Pages: 97-122