Dr. Shisheng Li
Professor
Comparative Biomedical Sciences (CBS)

Teaching Interests:
Biochemistry, cell and molecular biology, physiology.

Research Interests:
DNA repair and mutagenesis

 Awards & Honors:
  • 2019 Dean's Teacher Merit Honor Roll
  • 2018 Dean's Teacher Merit Honor Roll
  • 2017 Dean's Teacher Merit Honor Roll
  • 2015 Faculty distinguished scholar award
  • 2009 Pfizer award for research excellence
 Education:
  • PhD University of Wales, Swansea
  • MSc Nankai University
  • BS Henan Normal University
 Grants:
  • The role of Sen1 in transcription coupled DNA repair (TCR), NSF, $550,000.00
  • Dot1 and histone H3 K79 methylation in nucleotide excision repair, NSF, $642,444.00
  • DNA damage and repair in human melanocytes: relation to melanomagenesis mutations, NIH (R15), $457,962.00
  • High-throughput high-resolution mapping of DNA damage and repair in human cells., NIH (R03), $148,000.00
 Publications:
Journal Article, Academic Journal:
  • Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance, Ko, T.; Li, S., 2019, FASEB Journal , Volume: Epub ahead of print
  • Evidence that moderate eviction of Spt5 and promotion of error-free transcriptional bypass by Rad26 facilitates transcription coupled nucleotide excision repair, Selvam, K.; Ding, B.; Sharma, R.; Li, S., 2019, Journal of Molecular Biology , Volume: 431, Pages: 1322-1338
  • Facilitators and Repressors of Transcription Coupled DNA Repair in Saccharomyces cerevisiae, Li, W.; Li, S., 2017, Photochemistry and Photobiology , Volume: 93, Pages: 259–267
  • Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repair , Li, W.; Selvam, K.; Rahman, S.; Li, S., 2016, Nucleic Acids Research , Volume: 44, Number: 14, Pages: 6794-6802
  • Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: the ambiguous role of Rad26, Li, S., 2015, DNA Repair , Volume: 36, Pages: 43-48
  • High-resolution Digital Mapping of N-Methylpurines in Human Cells Reveals Modulation of Their Induction and Repair by Nearest-neighbor Nucleotides, Li, M.; Ko, T.; Li, S., 2015, Journal of Biological Chemistry , Volume: 290, Number: 38, Pages: 23148-23161
  • Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair, Li, S.; Li, W.; Selvam, K.; Ko, T., 2014, Nucleic Acids Research , Volume: 42, Number: 21, Pages: 13242-13253
  • Insights into how Spt5 functions in transcription elongation and repressing transcription coupled DNA repair, Li, S.; Li, W.; Giles, C., 2014, Nucleic Acids Research , Volume: 42, Number: 11, Pages: 7069-7083
  • Implication of posttranslational histone modifications in nucleotide excision repair, Li, S., 2012, International Journal of Molecular Sciences , Volume: 13, Number: 10, Pages: 12461-12486
  • Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair, Li, S.; Tatum, D.; Li, W.; Placer, M., 2011, Journal of Biological Chemistry , Volume: 286, Pages: 30304-30313
  • Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79., Li, S.; Tatum, D., 2011, Journal of Biological Chemistry , Volume: 286, Number: 20, Pages: 17530-17535
  • N-methylpurines are heterogeneously repaired in human mitochondria but not evidently repaired in yeast mitochondria., Li, S., 2011, DNA Repair , Volume: 10, Number: 1, Pages: 65-72
  • The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair., Li, S.; Li, B.; LeJeune, D., 2010, Journal of Biological Chemistry , Volume: 285, Pages: 5317-5326
Book, Textbook Chapter:
  • Nucleotide Excision Repair in S. cerevisiae, Li, S.; Tatum, D., 2011, Publisher: InTech Open Access Publisher, Pages: 97-122