Dr. Shaomian Yao
Associate Professor
Comparative Biomedical Sciences (CBS)
(225) 578-9889

Teaching Interests:
Cell and molecular biology

Research Interests:
My major research emphasis focuses on: (a) Molecular regulation of stem cell differentiation (b) Applications of stem cells in tissue regeneration and bio-fabrication.

 Awards & Honors:
  • 2019 Phi Zeta 2nd place in Basic Research poster competition (A Ramos, DVM Student)
  • 2018 CIMM REU 2nd place award in Poster competition (E. Mire, undergraduate student)
  • 2018 Dean's Teacher Merit Honor Roll
  • 2017 Dean's Teacher Merit Honor Roll
 Education:
  • PhD Louisiana State University
  • MS Louisiana State University
  • BS Guizhou Agricultral College
 Grants:
  • Molecular regulation underlying differentiation of dental pulp stem cell, NIH, $362,224.00
  • Laser-based 3D metal printing to fabricate medical implants for recruitment of human stem cells to enhance osseointegration, BOR, $10,000.00
  • Additive manufacturing for development of medical implants favoring osseointegration , BOR, $10,000.00
  • High-Resolution Raman System for Multidisciplinary Research at LSU , BOR,
  • Selective laser melting 3D printing to fabricate titanium medical implants favoring osseointegration , BOR, $10,000.00
  • Additive manufacturing and stem cell recruitment for enhancing osseointegration, Office of Research and Economic Development, LSU A&M, $50,000.00
  • Prevention of tooth eruption by inactivating the dental follicle with laser treatment, Sizhu LLC , $48,268.00
  • A selective laser melting system to enhance advanced manufacturing research and education, BOR, $186,800.00
  • Selective Laser Melting (SLM) based advanced manufacturing for dental implant application. , LSU, $10,000.00
  • Regulation of differentiation of dental pulp stem cells (DPSCs) by heat shock protein B8 and microRNA , BOR, $10,000.00
  • Conversion of somatic cells to pluripotent stem cells by auxin stimulation., LSU-SVM, $10,000.00
  • Local delivery of CSF-1 expression vector into dental tissues for inducing eruption of impacted teeth, LSU SVM, $10,000.00
  • Identification of potential genes causing loss of differentiation capability in dental follicle stem cells (DFSC) , LSU-SVM, $10,000.00
 Publications:
Journal Article, Academic Journal:
  • Indocyanine Green-assisted Dental Imaging in the First and Second Near-Infrared Windows as Compared with X-ray Imaging, Yao, Shaomian; Osborn, Michelle; Li, Zhongqiang; Ramirez, Alexandra; Hartzler, T; Xu, Jian; Zaid, W, 2019, Annals of the New York Academy of Sciences: Marrow , Volume: 1448, Pages: 42-51
  • Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival., Ngoc Tran, T; Stovall, K; Suantawee, T; Hu, Y; Yao, Shaomian; Yang, L; Adisakwattana, S; Cheng, Henrique, 2017, Cell proliferation , Volume: 50, Number: 5
  • Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca<sup>2+</sup> Channels., Suantawee, T; Elazab, S; Hsu, W; Yao, Shaomian; Cheng, Henrique; Adisakwattana, S, 2017, Nutrients , Volume: 9, Number: 8
  • Morphometric and ultrastructure studies of primordial follicles, and expression of estrogen-dependent genes in the ovaries of domestic cats, Odenheimer, Ariela; Yao, Shaomian; Kearney, Michael; Joudrey , Scott; Al-Bagdadi, Fakhri, 2016, J Microsc Ultrastruct , Volume: 4, Number: 1, Pages: 46-54
  • Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis., Al-Bagdadi, Fakhri; Geaghan, J; Young, J; Yao, Shaomian; Yoshimura, Masami; Matthew, J; Barona, H; Martinez-Ceballos, E, 2016, Ultrastructural Pathology , Volume: 15, Number: 30
  • Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis, Al-Bagdadi, Fakhri; Young, PhD , Matthew ; Geaghan, PhD, James ; Yao, Shaomian; Barona, PhD , Humberto; Martinez-Ceballos, PhD, Eduardo; Yoshimura, Masami, 2016, J Microsc Ultrastruct , Volume: 4, Number: 1, Pages: 46-54
  • MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation., Yao, Shaomian, 2016, Biological procedures online , Volume: 18, Pages: 8
  • Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects., Rezai-Rad, M; Bova, J; Orooji, M; Pepping, J; Qureshi, A; Del Piero, Fabio; Hayes, D; Yao, Shaomian, 2015, Cytotherapy , Volume: 17, Number: 11, Pages: 1572-81
  • The role of dentin matrix protein 1 (DMP1) in regulation of osteogenic differentiation of rat dental follicle stem cells (DFSCs), Yao, Shaomian; Rad, Maryam; Liu, Dawen; He, Hongzhi; Brook, Hunter; Wise, Gary, 2015, Archives of Oral Biology , Volume: 60, Number: 4, Pages: 546-556
  • Expression of bone morphogenetic protein 6 in dental follicle stem cells and its effect on osteogenic differentiation , Yao, Shaomian; Rad, Maryam; Wise, Gary; Gutierrez, Dina; He, Hongzhi; Liu, Dawen; Li, Chunhong, 2014, Cells Tissues and Organs , Volume: 198, Number: 6, Pages: 438-447
  • Activation of the proliferation and differentiation of dental follicle stem cells (DFSCs) by heat-stress, Yao, Shaomian; Rad, Maryam; Wise, Gary; Brooks, Hunter, 2013, Cell proliferation , Volume: 46, Number: 1, Pages: 58-66
  • Regulation of SFRP-1 expression in the rat dental, Yao, Shaomian; Liu, Dawen; Wise, Gary, 2012, Connect Tissue Res , Volume: 53, Number: 5, Pages: 366-372
  • Competitive electroporation formulation for cell therapy, Yao, Shaomian, 2011, Cancer Gene Ther , Volume: 18, Pages: 579-586
  • Hypoxia promotes growth of stem cells in dental follicle cell populations, Yao, Shaomian; Dai, Yuntao; He, Hongzhi ; Wise, Gary, 2011, Journal of Biomedical Science and Engineering , Volume: 4, Number: 6, Pages: 454-461
  • Requirement of alveolar bone formation for eruption of rat molars, Yao, Shaomian; Wise, Gary; Gutierrez DL, He H, Ring S, Yao S, Dina; He , Hongzhi ; Ring , Sherry, 2011, Eur J Oral Sci. , Volume: 119, Pages: 333-338
  • Proliferation of Dental Follicle Derived Cell Populations in Heat-stress conditions. , Yao, Shaomian; Gutierrez , Dina; He, Hongzhi; Dai, Yuntao; Liu , Dawen ; Wise, Gary, 2011, Cell Proliferation , Volume: 44, Pages: 486-493.
  • Electroporation to deliver plasmid DNA into rat dental tissues, Yao, Shaomian; Gutierrez, D; Ring, S; Liu, D; Wise, Gary, 2010, Journal of Gene Medicine , Volume: 12, Pages: 981-989
  • MyD88 expression in the rat dental follicle: Implications for osteoclastogenesis and tooth eruption., Yao, Shaomian; Liu, D; Wise, Gary, 2010, European Journal of Oral Sciences , Volume: 118, Pages: 333-341
  • TNF-alpha upregulates expression of BMP-2 and BMP-3 genes in the rat dental follicle--implications for tooth eruption., Yao, Shaomian; Prpic, V; Pan, F; Wise, Gary, 2010, Connect Tissue Res. , Volume: 51, Number: 1, Pages: 59-66
Journal Article, Professional Journal:
  • Endoscopic near-infrared dental imaging with indocyanine green: a pilot study. , Li, Z; Yao, Shaomian; Xu, J; Wu, Y; Li, C, 2018, Annals of the New York Academy of Sciences
  • Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation, Flanagan, M; Li, C; Dietrich, Marilyn; Richard, M; Yao, Shaomian, 2018, Cell Prolif
  • Involvement of heat-shock protein B8 and microRNAs in regulating differentiation of dental pulp stem cells, Flanagan, M; Li, C; Yao, Shaomian, 2016, International Association of Dental Research
  • Arginine vasopressin inhibits adipogenesis in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2015, Molecular and Cellular Endocrinology , Volume: 406, Pages: 1-9
  • Histamine-induced Ca2+ signaling is mediated by TRPM4 channels in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2014, Biochemical Journal , Volume: 463, Number: 1, Pages: 123-134
Scientific Abstract:
  • Effects of BMP signaling on osteogenic differentiation and tooth eruption., Hafez, Shireen; Yao, Shaomian; Wise, Gary, 2011