Dr. Shaomian Yao- LSU SVM Faculty

Dr. Shaomian Yao

Associate Professor

Comparative Biomedical Sciences (CBS)

(225) 578-9889

Teaching Interests:
Cell and molecular biology

Research Interests:
My major research emphasis focuses on: (a) Molecular regulation of stem cell differentiation (b) Applications of stem cells in tissue regeneration and bio-fabrication.

Awards & Honors:

2021 Phi Zeta Second place in Basic Research poster competition (Z Li, PHD Student) LSU-SVM February 20, 2020
2020 Phi Zeta third place in Basic Research poster competition (Z Li, PHD Student) LSU-SVM February 20, 2020
2019 Phi Zeta 2nd place in Basic Research poster competition (A Ramos, DVM Student)
2018 CIMM REU 2nd place award in Poster competition (E. Mire, undergraduate student)
2018 Dean's Teacher Merit Honor Roll
2017 Dean's Teacher Merit Honor Roll

Education:

PhD Louisiana State University
MS Louisiana State University
BS Guizhou Agricultral College

Grants:

Center for Pre-Clinical Disease Research , National Institutes of Health - NIH, $11,192,691.00
Molecular basis for the loss of differentiation capability in human bone marrow stem cells during expansion , National Institutes of Health, $350,812.00
Design a proof-of-concept non-ionizing-radiation imaging scheme to aid the diagnosis of critical dental diseases that cannot be detected by the prevalent dental X-ray/CT, LA BOR, $4,000.00
Molecular base of loss of osteogenic differentiation capability in human tissue-derived stem cells, LA BOR, $18,875.00
Laser-based 3D metal printing to fabricate medical implants for recruitment of human stem cells to enhance osseointegration, LA BOR, $10,000.00
Molecular regulation underlying differentiation of dental pulp stem cell, NIH, $362,224.00
Molecular basis for the loss of differentiation capability in human bone marrow stem cells during expansion (amendment application), CBS Department Bridge , $8,500.00
Additive manufacturing for development of medical implants favoring osseointegration , BOR, $10,000.00
Assessment of Human Tissue-derived Cells for Bone Bio-Engineering, LSU discovery grant, $2,500.00
High-Resolution Raman System for Multidisciplinary Research at LSU , BOR,
Selective laser melting 3D printing to fabricate titanium medical implants favoring osseointegration , BOR, $10,000.00
Additive manufacturing and stem cell recruitment for enhancing osseointegration, Office of Research and Economic Development, LSU A&M, $50,000.00
Prevention of tooth eruption by inactivating the dental follicle with laser treatment, Sizhu LLC , $48,268.00
A selective laser melting system to enhance advanced manufacturing research and education, BOR, $186,800.00
Selective Laser Melting (SLM) based advanced manufacturing for dental implant application. , LSU, $10,000.00
Regulation of differentiation of dental pulp stem cells (DPSCs) by heat shock protein B8 and microRNA , BOR, $10,000.00
Conversion of somatic cells to pluripotent stem cells by auxin stimulation., LSU-SVM, $10,000.00
Local delivery of CSF-1 expression vector into dental tissues for inducing eruption of impacted teeth, LSU SVM, $10,000.00
Identification of potential genes causing loss of differentiation capability in dental follicle stem cells (DFSC) , LSU-SVM, $10,000.00

Publications:
Research Report:

Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC-IP3 pathway and intracellular Ca 2+ signaling., Stovall, Kelsie; Tran, Tran; Suantawee, Tanawan; Yao, Shaomian; Gimble, Jeffrey; Adisakwattana, Sirichai; Cheng, Henrique, 2020

Journal Article, Professional Journal:

Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures , Guo, Steven; Ramos, Alex; Li, zhongqiong ; Yao, Hong; Xu, Jian; Yao, Shaomian, 2021, Journal of Biosciences and Medicines , Volume: 9, Number: 1, Pages: 16-29
Endoscopic near-infrared dental imaging with indocyanine green: a pilot study. , Li, Z; Yao, Shaomian; Xu, J; Wu, Y; Li, C, 2018, Annals of the New York Academy of Sciences
Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation, Flanagan, M; Li, C; Dietrich, Marilyn; Richard, M; Yao, Shaomian, 2018, Cell Prolif
Involvement of heat-shock protein B8 and microRNAs in regulating differentiation of dental pulp stem cells, Yao, Shaomian; Flanagan, M; Li, C, 2016, International Association of Dental Research
Arginine vasopressin inhibits adipogenesis in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2015, Molecular and Cellular Endocrinology , Volume: 406, Pages: 1-9
Histamine-induced Ca2+ signaling is mediated by TRPM4 channels in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2014, Biochemical Journal , Volume: 463, Number: 1, Pages: 123-134

Other:

Creating Structured Hydrogel Microenvironments for Regulating Stem Cell Differentiation, Mills, David; Luo, Yangyang; Elumalai, Anusha; Esteve, Savannah; Karnik, Sonali; Yao, Shaomian, 2020

Journal Article, Academic Journal:

Mouthwash to Deliver Indocyanine Green for Near Infrared Dental Fluorescence Imaging, Li, Zheng; Li, Zhongqiang ; Holamoge, Yoshita; Zaid, Waleed; Osborn, Michelle; Bhatta, Shradha; Jeyaseelan, Abhirami; Li, Yanping; Yao, Shaomian; Xu, Jian, 2020, Journal of Selected Topics in Quantum Electronics , Volume: 27, Number: 4, Pages: 1-8
Optimal imaging windows of indocyanine green-assisted near infrared dental imaging with rat model and its comparison to X-ray imaging, Li, Zhongqiang; Hartzler, T; Ramirez, Alexandra; Osborn, Michelle; Shan, X; Li, Y; Yao, Shaomian; Xu, Jian, 2020, Journal of Biophotonics , Volume: 13, Number: 6, Pages: e201960232
Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC-IP3 pathway and intracellular Ca 2+ signaling., Stovall, K; Suantawee, T; Yao, Shaomian; Gimble, J; Adisakwattana, S; Cheng, Henrique, 2020, Journal of cellular physiology , Volume: 235, Number: 2, Pages: 1723-1732
Improvement of osseointegration by recruiting stem cells to titanium implants fabricated with 3D printing, Bollman , M. ; Malbrue , R.; Li , C.; Yao , H.; Guo , S. ; Yao, Shaomian, 2019, Ann N Y Acad Sci.
Expression of microRNAs targeting heat shock protein B8 during in vitro expansion of dental pulp stem cells in regulating osteogenic differentiation., Yao, Shaomian; Li , C ; Budenski , AM; Li , P; Ramos, A ; Guo, S, 2019, Arch Oral Biol. , Volume: 107
Indocyanine-green-assisted near-infrared dental imaging - the feasibility of in vivo imaging and the optimization of imaging conditions, Li, Zhongqiang ; Yao, Shaomian; Xu, Jian, 2019, Scientific Reports
Indocyanine Green-assisted Dental Imaging in the First and Second Near-Infrared Windows as Compared with X-ray Imaging, Li, Zhongqiang; Zaid, W; Hartzler, T; Ramirez, Alexandra; Osborn, Michelle; Yao, Shaomian; Xu, Jian, 2019, Annals of the New York Academy of Sciences: Marrow , Volume: 1448, Pages: 42-51
Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival., Ngoc Tran, T; Stovall, K; Suantawee, T; Hu, Y; Yao, Shaomian; Yang, L; Adisakwattana, S; Cheng, Henrique, 2017, Cell proliferation , Volume: 50, Number: 5
Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels., Suantawee, T; Elazab, S; Hsu, W; Yao, Shaomian; Cheng, Henrique; Adisakwattana, S, 2017, Nutrients , Volume: 9, Number: 8
Morphometric and ultrastructure studies of primordial follicles, and expression of estrogen-dependent genes in the ovaries of domestic cats, Odenheimer, Ariela; Yao, Shaomian; Kearney, Michael; Joudrey , Scott; Al-Bagdadi, Fakhri, 2016, J Microsc Ultrastruct , Volume: 4, Number: 1, Pages: 46-54
Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis., Al-Bagdadi, Fakhri; Matthew, J; Young, J; Geaghan, J; Yao, Shaomian; Barona, H; Martinez-Ceballos, E; Yoshimura, Masami, 2016, Ultrastructural Pathology , Volume: 15, Number: 30
Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis, Al-Bagdadi, Fakhri; Young, PhD , Matthew ; Geaghan, PhD, James ; Yao, Shaomian; Barona, PhD , Humberto; Martinez-Ceballos, PhD, Eduardo; Yoshimura, Masami, 2016, J Microsc Ultrastruct , Volume: 4, Number: 1, Pages: 46-54
MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation., Yao, Shaomian, 2016, Biological procedures online , Volume: 18, Pages: 8
Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects., Rezai-Rad, M; Bova, J; Orooji, M; Pepping, J; Qureshi, A; Del Piero, Fabio; Hayes, D; Yao, Shaomian, 2015, Cytotherapy , Volume: 17, Number: 11, Pages: 1572-81
The role of dentin matrix protein 1 (DMP1) in regulation of osteogenic differentiation of rat dental follicle stem cells (DFSCs), Rad, Maryam; Liu, Dawen; He, Hongzhi; Brook, Hunter; Wise, Gary; Yao, Shaomian, 2015, Archives of Oral Biology , Volume: 60, Number: 4, Pages: 546-556
Expression of bone morphogenetic protein 6 in dental follicle stem cells and its effect on osteogenic differentiation , Yao, Shaomian; He, Hongzhi; Gutierrez, Dina; Rad, Maryam; Liu, Dawen; Li, Chunhong; Wise, Gary, 2014, Cells Tissues and Organs , Volume: 198, Number: 6, Pages: 438-447
Activation of the proliferation and differentiation of dental follicle stem cells (DFSCs) by heat-stress, Rad, Maryam; Wise, Gary; Brooks, Hunter; Yao, Shaomian, 2013, Cell proliferation , Volume: 46, Number: 1, Pages: 58-66
Regulation of SFRP-1 expression in the rat dental, Liu, Dawen; Yao, Shaomian; Wise, Gary, 2012, Connect Tissue Res , Volume: 53, Number: 5, Pages: 366-372
Competitive electroporation formulation for cell therapy, Yao, Shaomian, 2011, Cancer Gene Ther , Volume: 18, Pages: 579-586
Hypoxia promotes growth of stem cells in dental follicle cell populations, Dai, Yuntao; He, Hongzhi ; Wise, Gary; Yao, Shaomian, 2011, Journal of Biomedical Science and Engineering , Volume: 4, Number: 6, Pages: 454-461
Requirement of alveolar bone formation for eruption of rat molars, Wise, Gary; Gutierrez DL, He H, Ring S, Yao S, Dina; He , Hongzhi ; Ring , Sherry; Yao, Shaomian, 2011, Eur J Oral Sci. , Volume: 119, Pages: 333-338
Proliferation of Dental Follicle Derived Cell Populations in Heat-stress conditions. , Yao, Shaomian; Gutierrez , Dina; He, Hongzhi; Dai, Yuntao; Liu , Dawen ; Wise, Gary, 2011, Cell Proliferation , Volume: 44, Pages: 486-493.
Electroporation to deliver plasmid DNA into rat dental tissues, Yao, Shaomian; Gutierrez, D; Ring, S; Liu, D; Wise, Gary, 2010, Journal of Gene Medicine , Volume: 12, Pages: 981-989
MyD88 expression in the rat dental follicle: Implications for osteoclastogenesis and tooth eruption., Liu, D; Yao, Shaomian; Wise, Gary, 2010, European Journal of Oral Sciences , Volume: 118, Pages: 333-341
TNF-alpha upregulates expression of BMP-2 and BMP-3 genes in the rat dental follicle--implications for tooth eruption., Yao, Shaomian; Prpic, V; Pan, F; Wise, Gary, 2010, Connect Tissue Res. , Volume: 51, Number: 1, Pages: 59-66

Scientific Abstract:

Effects of BMP signaling on osteogenic differentiation and tooth eruption., Hafez, Shireen; Yao, Shaomian; Wise, Gary, 2011