Dr. Rhonda Cardin
Professor
Pathobiological Sciences (PBS)

Research Interests:
My virology and pathogenesis expertise spans all of the herpesvirus subfamilies (alpha, beta, and gamma). As a postdoctoral fellow at Stanford University School of Medicine, I trained in the lab of Dr. Ed Mocarski, a leading expert in CMV research. In the lab of Dr. Peter Doherty, 1996 Nobel laureate, at St. Jude Children’s Research Hospital, I directed the murine gammaherpesvirus-68 (MHV-68) immunology studies, which lead to 17 publications. I also have research experience in the pharmaceutical industry evaluating antiviral compounds in herpesvirus animal models. Since 2003, I have been Co-PI on a NIH contract award which evaluates new antiviral drugs and vaccines against HSV and CMV and have been PI of multiple large industry contract studies. Relevant to this COBRE application, I have been funded by AHA and NIH to study the role of the CMV-encoded viral GPCRs that activate signaling pathways to promote cell survival and viral persistence. I recently became PI of the LSU SVM NIH COBRE Center for Experimental Infectious Disease Research (CEIDR) when Dr. Gus Kousoulas became PI of the INBRE at LSU. In addition to my CMV research at LSU, my duties include overseeing research and core facilities at LSU SVM. For this COBRE, I will serve as Subcontract PI and Administrative Core Director to achieve the proposed goals.

 Education:
  • Postdoc Postdoc Stanford University School of Medicine
  • PhD Microbiology at Louisiana State University
  • Biology PhD Program PhD Program in Biology at Tulane University
  • AB Biology and Psychology at Washington University
 Grants:
  • Mouse and Guinea Pig Models for Cytomegalovirus and Herpes Simplex Viruses, NIH-NIAID/Cincinnati Children's Hospital Med. Ctr., $126,307.00
 Publications:
Journal Article, Academic Journal:
  • Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus., Farrell, H; Bruce, K; Lawler, C; Cardin, Rhonda; Davis-Poynter, N; Stevenson, P, 2016, PLoS pathogens , Volume: 12, Number: 12, Pages: e1006069
  • Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection., Cardin, Rhonda; Bravo, F; Pullum, D; Orlinger, K; Watson, E; Aspoeck, A; Fuhrmann, G; Guirakhoo, F; Monath, T; Bernstein, D, 2016, Vaccine , Volume: 34, Number: 17, Pages: 1993-9
  • Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs., Bernstein, D; Bravo, F; Pullum, D; Shen, H; Wang, M; Rahman, A; Glazer, R; Cardin, Rhonda, 2015, Antiviral chemistry & chemotherapy , Volume: 24, Number: 1, Pages: 19-27
  • Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes., Hill, J; Quenelle, D; Cardin, Rhonda; Vogel, J; Clement, C; Bravo, F; Foster, T; Bosch-Marce, M; Raja, P; Lee, J; Bernstein, D; Krause, P; Knipe, D; Kristie, T, 2014, Science translational medicine , Volume: 6, Number: 265, Pages: 265ra169
  • Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes., Bernstein, D; Cardin, Rhonda; Bravo, F; Earwood, J; Clark, J; Li , Y; Mishra, P; Li , C; Nayak, B; Miller, A; Wu, T; Cooke, M; Valiante, N, 2014, Antiviral chemistry & chemotherapy , Volume: 23, Number: 5, Pages: 189-96
  • Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model., Farrell, H; Abraham, A; Cardin, Rhonda; Mølleskov-Jensen, A; Rosenkilde, M; Davis-Poynter, N, 2013, Journal of virology , Volume: 87, Number: 7, Pages: 4112-7
  • N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs., Bernstein, D; Bravo, F; Clark, J; Earwood, J; Rahman, A; Glazer, R; Cardin, Rhonda, 2011, Antiviral research , Volume: 92, Number: 2, Pages: 386-8
  • Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues., Farrell, H; Abraham, A; Cardin, Rhonda; Sparre-Ulrich, A; Rosenkilde, M; Spiess, K; Jensen, T; Kledal, T; Davis-Poynter, N, 2011, Journal of virology , Volume: 85, Number: 12, Pages: 6091-5
  • Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig., Bernstein, D; Earwood, J; Bravo, F; Cohen, G; Eisenberg, R; Clark, J; Fairman, J; Cardin, Rhonda, 2011, Vaccine , Volume: 29, Number: 11, Pages: 2071-8
  • Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection., Bravo, F; Bernstein, D; Beadle, J; Hostetler, K; Cardin, Rhonda, 2011, Antimicrobial agents and chemotherapy , Volume: 55, Number: 1, Pages: 35-41
  • Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy., Farley, N; Bernstein, D; Bravo, F; Earwood, J; Sawtell, N; Cardin, Rhonda, 2010, Antiviral research , Volume: 86, Number: 2, Pages: 188-95