Dr. Olalekan Ogundele
Comparative Biomedical Sciences (CBS)
(225) 578-9103

Teaching Interests:
Gross Anatomy, Cell, and Developmental Biology, Histology and Neurobiology.

Research Interests:
The brain contains billions of neurons, with each one forming several synaptic connections. Through these structural and electrochemical interactions, groups of neurons, encode information by generating bursts of action potential and post-synaptic current (excitation). However, if unchecked, hyperexcitation can lead to seizures or degenerative changes in the brain. The goal of my research is to investigate novel mechanisms utilized by small conductance channels (SK2) in the regulation of hippocampal neural network excitability. Specifically, we will ascertain how SK2 modulates dendritic spine localization of T286 pCaMKIIα towards controlling network excitation. Through in vivo extracellular voltage recording and optogenetics, we have begun to dissect the significance of SK2 and T286pCaMKIIα activity coupling in CA1 firing rate homeostasis, and their dysregulation in cognitive disorders. Combining optogenetics with neural recording is noteworthy as it allows for simultaneous assessment and modulation of neural activity in awake mice undertaking a quantifiable cognitive-behavioral test. This has also allowed us to determine the correlation between synaptic proteins, burst encoding, and behavior in normal and mutant mice for chronic durations (6-8 months). For this purpose, we use a range of transgenic mouse lines with specific mutations that produce dendritic spine loss and defective synaptic plasticity. Other methods used in my lab include the Cre-lox technique for gene silencing/expression, optogenetic-based neural circuit tracing, neuroanatomical tracing with 3D-fluorescence imaging, immunofluorescence, expansion microscopy (ExM), CLARITY (iDisco), confocal microscopy, transmission electron microscopy (TEM), immunoblotting, and RT-PCR.

 Awards & Honors:
  • 2020 Deans Merit Honor Roll
  • 2020 Dinstinguished Teacher of the Year (Class of 2023)
  • 2020 Zoetis Award
  • 2019 Deans Merit Honor Roll
  • 2018 Dean's Teachers Merit Honor Roll
  • 2015 IBRO-ISN Postdoctoral Fellowship
  • 2014 IBRO-ARC Short Stay Grant
  • 2014 IBRO-Canadian School on Synaptic Plasticity
  • 2013 Disease Model Mechanism Fellowship
  • 2013 ISN-CAEN 1B Research Fellowship
  • 2010 Carnegie/Zeiss Fellowship
  • 2010 Doctoral Fellowship
 Education:
  • Post-Doc Louisiana State University
  • PhD University of Ilorin, College of Health Sciences
  • MSc University of Ilorin, College of Health Sciences
  • BS University of Ilorin, College of Health Sciences
 Grants:
  • Effect of Vitamin D3 receptor stimulation on dopamine metabolism and calcium toxicity in 6-hydroxydopamine lesioned nigrostriatal system, National Research Fund (NRF) Tertiary Education Trust Fund (TETFund), $53,957.00
 Publications:
Journal Article, Academic Journal:
  • Disc1 carrier mice express distinct alterations in neural pIGF-1R, and related kinase activity, Lee, Charles; Ogundele , Olalekan; Sultana, Razia; Shrestha, Amita, 2020, Frontiers in Cellular Neuroscience , Volume: 14, Pages: 94
  • SK channel modulates synaptic plasticity by tuning CaMKIIα/β dynamics, Shresta, Amita; Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Frontiers in Cellular Neuroscience , Volume: 11, Pages: 18
  • Contrasting characteristic behaviors among common laboratory mouse strains, Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Royal Society Open Science , Volume: 6, Pages: 190574
  • Upregulated SK2 expression, and impaired CaMKII phosphorylation are shared synaptic defects between 16p11.2del and 129S:Δdisc1 mutant mice, Sultana, Razia; Gandhi, Tanya; Davila, Alexandra; Lee, Charles; Ogundele , Olalekan, 2018, ASN Neuro , Volume: 10, Pages: 1759091418817641
  • CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: putative roles for IGF-1R and TLR4, Ogundele , Olalekan; Lee, Charles, 2018, Brain Research Bulletin , Volume: 137, Pages: 53-70
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Systemic sympathoexcitation was associated with paraventricular hypothalamic phosphorylation of synaptic CaMKIIα and MAPK/ErK, Ogundele , Olalekan; Rosa, Fernando; Lee, Charles; Francis, Joseph; Dharmakumar, Rohan, 2017, Frontiers in Neuroscience , Volume: 11, Pages: 447
  • Thalamic dopaminergic neurons project to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, The Anatomical Record , Volume: 300, Number: 7, Pages: 1307-1314
  • Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy, Ogundele , Olalekan; Ebenezer, Philip; Lee, Charles; Francis, Joseph, 2017, Neuroscience , Volume: 353, Pages: 147-165
  • IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function., Pardo, J; Abba, M; Lacunza, E; Ogundele, O; Paiva, I; Morel, G; Outeiro, T; Goya, R, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences
  • Long-lasting training in the Barnes maze prompts hippocampal spinogenesis and habituation in rats., Uriarte, M; Ogundele, O; Pardo, J, 2017, Neuroreport , Volume: 28, Number: 6, Pages: 307-312
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2016, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Neural and behavioural changes in male periadolescent mice after prolonged nicotine-MDMA treatment., Adeniyi, P; Ishola, A; Laoye, B; Olatunji, B; Bankole, O; Shallie, P; Ogundele, O, 2016, Metabolic brain disease , Volume: 31, Number: 1, Pages: 93-107
  • Dopamine binds calmodulin during autoregulation of dopaminergic D2 receptor signaling through CaMKIIα-calmodulin complex., Laoye, B; Okurumeh, O; Obagaye, O; Olagunju, M; Bankole, O; Olubiyi, O; Ogundele, O, 2016, Journal of receptor and signal transduction research , Volume: 36, Number: 3, Pages: 271-7
  • -NMDA R/+VDR pharmacological phenotype as a novel therapeutic target in relieving motor-cognitive impairments in Parkinsonism., Ogundele, O; Nanakumo, E; Ishola, A; Obende, O; Enye, L; Balogun, W; Cobham, A; Abdulbasit, A, 2015, Drug and chemical toxicology , Volume: 38, Number: 4, Pages: 415-27
  • Motor and memory function in rat models of cyanide toxicity and vascular occlusion induced ischemic injury., Ogundele, O; Adeniyi, P; Ajonijebu, D; Abdulbasit, A; Cobham, A; Ishola, A; Balogun, G, 2014, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 21, Number: 3, Pages: 191-8
  • Glia activation and its role in oxidative stress., Ogundele, O; Omoaghe, A; Ajonijebu, D; Ojo, A; Fabiyi, T; Olajide, O; Falode, D; Adeniyi, P, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 483-93
  • NMDA-R inhibition affects cellular process formation in Tilapia melanocytes; a model for pigmented adrenergic neurons in process formation and retraction., Ogundele, O; Okunnuga, A; Fabiyi, T; Olajide, O; Akinrinade, I; Adeniyi, P; Ojo, A, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 541-51