Dr. Olalekan Ogundele
Comparative Biomedical Sciences (CBS)
(225) 578-9103

Biography:
I am an anatomist with combined human and veterinary anatomy teaching experience. I trained at the College of Health Sciences, University of Ilorin (Nigeria) where I obtained Bachelors, Masters, and Doctorate degrees in Anatomy. I taught anatomy for several years in medical schools before joining the Department of Comparative Biomedical Sciences as a Research Associate (Neuroscience). In 2017, I joined the faculty at the LSU School of Veterinary Medicine.



Teaching Interests:
Gross Anatomy (VMED 5123, VMED 5124, and VMED 51215), Histology (VMED 5132), and Neuroanatomy (VMED 5171 Lab).
I am the current coordinator of the spring semester comparative anatomy course (VMED 5125), and Anatomy Open House.



Research Interests:
The brain contains many neurons that are interconnected by synapses. In the cognitive centers, synchronous excitation of neurons produces action potential spikes and bursts that temporally encode information at the network level. My laboratory investigates synaptic mechanisms that govern network excitability and rate coding in the hippocampus. Also, we explore the anatomical distribution of midbrain presynaptic terminals in the hippocampus and use electrophysiology to assess their function in putative multi-unit synchrony in vivo.

We study small conductance (SK2) channel gating of synaptic kinases as a novel mechanism for neural excitability regulation. We use molecular biology, imaging, and protein analysis methods to dissect the mechanism of activity coupling between SK2 and dendritic spine translocation of CaM kinases (CaMKIIα) in the hippocampus. Using high impedance neural probes, we assess firing and burst rates by sampling extracellular action potentials in the hippocampus of wild type and transgenic mice with specific mutations related to SK2 or CaMKIIα function. By combining in vivo recording with pharmacology and optogenetics, we assess activity coupling between SK2 potentiation and dendritic spine enrichment of T286 pCaMKIIα during hippocampal network stimulation.

At the neural circuit level, we are interested in the function of midbrain dopamine and glutamate presynaptic terminals in the hippocampus. We use neuroanatomical (retrograde/anterograde) tracing methods to map these terminals in the layers of the hippocampus. We also combine high-throughput silicon probe recording with optogenetics (AAV/Cre-lox) to test functional connections between midbrain dopamine or glutamate neuron groups and hippocampal neurons. By combining anatomical and electrophysiological tracing methods, we assess the physiological basis of the anatomical maps in putative (CA1) pyramidal firing rate and putative unit synchrony. Combining optogenetics with neural recording is noteworthy as it permits the modulation of neuronal activity in awake mice undertaking a quantifiable cognitive test. We are interested in behavioral tests that can assess spatial learning and reward motivation in learning.

 Awards & Honors:
  • 2020 Innovation in Teaching Award
  • 2020 Dean's Merit Honor Roll
  • 2020 Distinguished Teacher of the Year (Class of 2023)
  • 2020 Zoetis Teacher of the Year Award
  • 2019 Dean's Merit Honor Roll
  • 2018 Dean's Merit Honor Roll
  • 2015 IBRO-ISN Postdoctoral Fellowship
  • 2014 IBRO-ARC Short Stay Grant
  • 2014 IBRO-Canadian School on Synaptic Plasticity
  • 2013 Disease Model Mechanism Fellowship
  • 2013 ISN-CAEN 1B Research Fellowship
  • 2010 Carnegie/Zeiss Fellowship
  • 2010 Doctoral Fellowship
 Education:
  • Post-Doc Louisiana State University
  • PhD University of Ilorin, College of Health Sciences
  • MSc University of Ilorin, College of Health Sciences
  • BS University of Ilorin, College of Health Sciences
 Grants:
  • Targeting Nigrostriatal SK Channel to Regulate Thalamocortical Synchrony in Motor Function, Department of Comparative Biomedical Sciences, $9,600.00
  • Attenuating Mechanical Lung Damage in the Progression of Sepsis; a Novel Neural Approach, NIH/NIGMS, $30,000.00
  • Neural plasticity in a disc1 model of schizophrenia, Department of Comparative Biomedical Sciences, $5,000.00
  • IGF-1R dysregulation in autism, LSU SVM, $8,000.00
  • Effect of Vitamin D3 receptor stimulation on dopamine metabolism and calcium toxicity in 6-hydroxydopamine lesioned nigrostriatal system, National Research Fund (NRF) Tertiary Education Trust Fund (TETFund), $53,957.00
 Publications:
Journal Article, Academic Journal:
  • Positive Modulation of SK Channel Impedes Neuron-Specific Cytoskeletal Organization and Maturation., Shrestha, Amita; Sultana, Razia; Adeniyi, Philip; Lee, Charles; Ogundele, Olalekan, 2020, Developmental Neuroscience , Volume: 42, Number: 1, Pages: 59-71
  • Vitamin D attenuated 6-OHDA-induced behavioral deficits, dopamine dysmetabolism, oxidative stress and neuro-inflammation in mice, Owoyele, Bamidele; Bayo-Olugbami, Adedamola; Nafiu, Abdulrazaq; Ogundele , Olalekan; Lee, Charles; Amin, Abdulbasit, 2020, Nutritional Neuroscience , Pages: 1-12
  • Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus., Shrestha, A; Adeniyi, P; Ogundele, O, 2020, Journal of visualized experiments : JoVE , Number: 163
  • Distribution of VTA Glutamate and Dopamine Terminals, and their Significance in CA1 Neural Network Activity., Adeniyi, P; Shrestha, A; Ogundele, O, 2020, Neuroscience
  • Disc1 carrier mice express distinct alterations in neural pIGF-1R, and related kinase activity, Lee, Charles; Ogundele , Olalekan; Sultana, Razia; Shrestha, Amita, 2020, Frontiers in Cellular Neuroscience , Volume: 14, Pages: 94
  • SK channel modulates synaptic plasticity by tuning CaMKIIα/β dynamics, Shresta, Amita; Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Frontiers in Cellular Neuroscience , Volume: 11, Pages: 18
  • Contrasting characteristic behaviors among common laboratory mouse strains, Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Royal Society Open Science , Volume: 6, Pages: 190574
  • Upregulated SK2 expression, and impaired CaMKII phosphorylation are shared synaptic defects between 16p11.2del and 129S:Δdisc1 mutant mice, Sultana, Razia; Gandhi, Tanya; Davila, Alexandra; Lee, Charles; Ogundele , Olalekan, 2018, ASN Neuro , Volume: 10, Pages: 1759091418817641
  • A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation., Ogundele, O; Pardo, J; Francis, Joseph; Goya, R; Lee, Charles, 2018, Frontiers in neuroanatomy , Volume: 12, Pages: 35
  • CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: putative roles for IGF-1R and TLR4, Ogundele , Olalekan; Lee, Charles, 2018, Brain Research Bulletin , Volume: 137, Pages: 53-70
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Systemic sympathoexcitation was associated with paraventricular hypothalamic phosphorylation of synaptic CaMKIIα and MAPK/ErK, Ogundele , Olalekan; Rosa, Fernando; Lee, Charles; Francis, Joseph; Dharmakumar, Rohan, 2017, Frontiers in Neuroscience , Volume: 11, Pages: 447
  • Thalamic dopaminergic neurons project to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, The Anatomical Record , Volume: 300, Number: 7, Pages: 1307-1314
  • Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy, Ogundele , Olalekan; Ebenezer, Philip; Lee, Charles; Francis, Joseph, 2017, Neuroscience , Volume: 353, Pages: 147-165
  • IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function., Pardo, J; Abba, M; Lacunza, E; Ogundele, O; Paiva, I; Morel, G; Outeiro, T; Goya, R, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences
  • Long-lasting training in the Barnes maze prompts hippocampal spinogenesis and habituation in rats., Uriarte, M; Ogundele, O; Pardo, J, 2017, Neuroreport , Volume: 28, Number: 6, Pages: 307-312
  • Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicity in vivo., Ogundele, O; Wasiu Gbolahan, B; Emmanuel Cobham, A; Azeez Olakunle, I; Abdulbasit, A, 2017, Drug and chemical toxicology , Volume: 40, Number: 1, Pages: 101-109
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2016, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex., Olajide, O; Enaibe, B; Bankole, O; Akinola, O; Laoye, B; Ogundele, O, 2016, Metabolic brain disease , Volume: 31, Number: 1, Pages: 25-35
  • Neural and behavioural changes in male periadolescent mice after prolonged nicotine-MDMA treatment., Adeniyi, P; Ishola, A; Laoye, B; Olatunji, B; Bankole, O; Shallie, P; Ogundele, O, 2016, Metabolic brain disease , Volume: 31, Number: 1, Pages: 93-107
  • Dopamine binds calmodulin during autoregulation of dopaminergic D2 receptor signaling through CaMKIIα-calmodulin complex., Laoye, B; Okurumeh, O; Obagaye, O; Olagunju, M; Bankole, O; Olubiyi, O; Ogundele, O, 2016, Journal of receptor and signal transduction research , Volume: 36, Number: 3, Pages: 271-7
  • -NMDA R/+VDR pharmacological phenotype as a novel therapeutic target in relieving motor-cognitive impairments in Parkinsonism., Ogundele, O; Nanakumo, E; Ishola, A; Obende, O; Enye, L; Balogun, W; Cobham, A; Abdulbasit, A, 2015, Drug and chemical toxicology , Volume: 38, Number: 4, Pages: 415-27
  • Fluoride and aluminium disturb neuronal morphology, transport functions, cholinesterase, lysosomal and cell cycle activities., Akinrinade, I; Memudu, A; Ogundele, O, 2015, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 22, Number: 2, Pages: 105-15
  • Interplay of glia activation and oxidative stress formation in fluoride and aluminium exposure., Akinrinade, I; Memudu, A; Ogundele, O; Ajetunmobi, O, 2015, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 22, Number: 1, Pages: 39-48
  • Bax modulates neuronal survival while p53 is unaltered after Cytochrome C induced oxidative stress in the adult olfactory bulb in vivo., Ogundele, O; Sanya, O, 2015, Annals of neurosciences , Volume: 22, Number: 1, Pages: 19-25
  • Cerebrovascular changes in the rat brain in two models of ischemia., Ogundele, O; Ajonijebu, D; Adeniyi, P; Alade, O; Balogun, W; Cobham, A; Ishola, A; Abdulbasit, A, 2014, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 21, Number: 3, Pages: 199-209
  • Motor and memory function in rat models of cyanide toxicity and vascular occlusion induced ischemic injury., Ogundele, O; Adeniyi, P; Ajonijebu, D; Abdulbasit, A; Cobham, A; Ishola, A; Balogun, G, 2014, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 21, Number: 3, Pages: 191-8
  • Glia activation and its role in oxidative stress., Ogundele, O; Omoaghe, A; Ajonijebu, D; Ojo, A; Fabiyi, T; Olajide, O; Falode, D; Adeniyi, P, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 483-93
  • NMDA-R inhibition affects cellular process formation in Tilapia melanocytes; a model for pigmented adrenergic neurons in process formation and retraction., Ogundele, O; Okunnuga, A; Fabiyi, T; Olajide, O; Akinrinade, I; Adeniyi, P; Ojo, A, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 541-51
  • Cadmium increases the sensitivity of adolescent female mice to nicotine-related behavioral deficits., Adeniyi, P; Olatunji, B; Ishola, A; Ajonijebu, D; Ogundele, O, 2014, Behavioural neurology , Volume: 2014, Pages: 360978
  • Role of Se+Zn in regeneration (Ki-67) following Pb toxicity (p53andcad) in the germinal epithelium of adult Wistar rats., Falana, B; Ogundele, O; Duru, F; Oshinubi, A; Falode, D, 2013, Pakistan journal of biological sciences : PJBS , Volume: 16, Number: 2, Pages: 67-73