Dr. Olalekan Ogundele
Comparative Biomedical Sciences (CBS)
(225) 578-9103

Teaching Interests:
Gross Anatomy, Cell and Developmental Biology, Histology and Neurobiology.

Research Interests:
Our work is focused on the synaptic mechanism of developmental neuropsychiatric disorders that are characterized by an abnormal socio-cognitive function. Specifically, we are interested in hippocampal synaptic switch systems governed by calcium-calmodulin-dependent kinase II alpha (CaMKIIα), and their role in the modulation of synaptic plasticity in early life stress. Currently, we are developing techniques to directly quantify the extent of CaMKIIα phosphorylation in hippocampal (CA1) dendritic spines when various discrete neural circuits in the stress integration pathway are being activated or inhibited during the critical phases of neurodevelopment. Some of the methods we use include; high throughput in vivo neural recording combined with behavioral tests, 3D-fluorescence and ultramicroscopic imaging of CA1 dendritic spines, in vivo cell-specific neural manipulation (Chemogenetics and Optogenetics), neuroanatomical tracing and neurochemical analysis technique. The goal of our research is to determine the significance of neural CaMKIIα phosphorylation patterns in the cause of defective socio-cognitive behavior that may result from early life stress exposure. Ultimately, we sought to elucidate some of the changes that may occur in stress integration sub-circuits, and how they alter the viability of developing CA1 synapses in behaviorally characterized mice.

 Awards & Honors:
  • 2019 Deans Merit Honor Roll
  • 2018 Dean's Teachers Merit Honor Roll
  • 2015 IBRO-ISN Postdoctoral Fellowship
  • 2014 IBRO-ARC Short Stay Grant
  • 2014 IBRO-Canadian School on Synaptic Plasticity
  • 2013 Disease Model Mechanism Fellowship
  • 2013 ISN-CAEN 1B Research Fellowship
  • 2010 Carnegie/Zeiss Fellowship
  • 2010 Doctoral Fellowship
 Education:
  • Post-Doc Louisiana State University
  • PhD University of Ilorin, College of Health Sciences
  • MSc University of Ilorin, College of Health Sciences
  • BS University of Ilorin, College of Health Sciences
 Grants:
  • Effect of Vitamin D3 receptor stimulation on dopamine metabolism and calcium toxicity in 6-hydroxydopamine lesioned nigrostriatal system, National Research Fund (NRF) Tertiary Education Trust Fund (TETFund), $53,957.00
 Publications:
Journal Article, Academic Journal:
  • SK2 modulates synaptic plasticity by tuning synaptic CaMKII activity, Shresta, Amita; Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Frontiers in Cellular Neuroscience , Volume: 11, Pages: 18
  • Contrasting characteristic behaviors among common laboratory mouse strains, Sultana, Razia; Lee, Charles; Ogundele , Olalekan, 2019, Royal Society Open Science , Volume: 6, Pages: 190574
  • Upregulated SK2 expression, and impaired CaMKII phosphorylation are shared synaptic defects between 16p11.2del and 129S:Δdisc1 mutant mice, Sultana, Razia; Gandhi, Tanya; Davila, Alexandra; Lee, Charles; Ogundele , Olalekan, 2018, ASN Neuro , Volume: 10, Pages: 1759091418817641
  • CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: putative roles for IGF-1R and TLR4, Ogundele , Olalekan; Lee, Charles, 2018, Brain Research Bulletin , Volume: 137, Pages: 53-70
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Systemic sympathoexcitation was associated with paraventricular hypothalamic phosphorylation of synaptic CaMKIIα and MAPK/ErK, Ogundele , Olalekan; Rosa, Fernando; Lee, Charles; Francis, Joseph; Dharmakumar, Rohan, 2017, Frontiers in Neuroscience , Volume: 11, Pages: 447
  • Thalamic dopaminergic neurons project to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, The Anatomical Record , Volume: 300, Number: 7, Pages: 1307-1314
  • Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy, Ogundele , Olalekan; Ebenezer, Philip; Lee, Charles; Francis, Joseph, 2017, Neuroscience , Volume: 353, Pages: 147-165
  • IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function., Pardo, J; Abba, M; Lacunza, E; Ogundele, O; Paiva, I; Morel, G; Outeiro, T; Goya, R, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences
  • Long-lasting training in the Barnes maze prompts hippocampal spinogenesis and habituation in rats., Uriarte, M; Ogundele, O; Pardo, J, 2017, Neuroreport , Volume: 28, Number: 6, Pages: 307-312
  • Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2016, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
  • Neural and behavioural changes in male periadolescent mice after prolonged nicotine-MDMA treatment., Adeniyi, P; Ishola, A; Laoye, B; Olatunji, B; Bankole, O; Shallie, P; Ogundele, O, 2016, Metabolic brain disease , Volume: 31, Number: 1, Pages: 93-107
  • Dopamine binds calmodulin during autoregulation of dopaminergic D2 receptor signaling through CaMKIIα-calmodulin complex., Laoye, B; Okurumeh, O; Obagaye, O; Olagunju, M; Bankole, O; Olubiyi, O; Ogundele, O, 2016, Journal of receptor and signal transduction research , Volume: 36, Number: 3, Pages: 271-7
  • -NMDA R/+VDR pharmacological phenotype as a novel therapeutic target in relieving motor-cognitive impairments in Parkinsonism., Ogundele, O; Nanakumo, E; Ishola, A; Obende, O; Enye, L; Balogun, W; Cobham, A; Abdulbasit, A, 2015, Drug and chemical toxicology , Volume: 38, Number: 4, Pages: 415-27
  • Motor and memory function in rat models of cyanide toxicity and vascular occlusion induced ischemic injury., Ogundele, O; Adeniyi, P; Ajonijebu, D; Abdulbasit, A; Cobham, A; Ishola, A; Balogun, G, 2014, Pathophysiology : the official journal of the International Society for Pathophysiology , Volume: 21, Number: 3, Pages: 191-8
  • Glia activation and its role in oxidative stress., Ogundele, O; Omoaghe, A; Ajonijebu, D; Ojo, A; Fabiyi, T; Olajide, O; Falode, D; Adeniyi, P, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 483-93
  • NMDA-R inhibition affects cellular process formation in Tilapia melanocytes; a model for pigmented adrenergic neurons in process formation and retraction., Ogundele, O; Okunnuga, A; Fabiyi, T; Olajide, O; Akinrinade, I; Adeniyi, P; Ojo, A, 2014, Metabolic brain disease , Volume: 29, Number: 2, Pages: 541-51