Dr. Michelle Osborn
Assistant Professor
Comparative Biomedical Sciences (CBS)

Teaching Interests:
veterinary anatomy, comparative vertebrate anatomy, histology, zoology, evolution

Research Interests:
We apply the principles of functional and evolutionary morphology to the study of complex structural systems of model organisms to answer causal, “how?” questions and evolutionary, “why?” questions. This involves natural experiments to test specific hypotheses. For example, we study the head-neck-shoulder apparatus as an example of a complex system in various vertebrates (e.g., the bipedal human; the quadrupedal cat, dog, and horse; and the tetrapodal salamander) to understand its function in each animal and to reconstruct its evolutionary history. We also study pathomechanical postures and movements of the skeletomuscular system in various vertebrates that may be related to tissue degeneration. We use an eclectic set of techniques (e.g., biometrics, statistics, gross and micro-dissection, histology, force analysis, imaging and animation in 2D and 3D) and collaborate with other anatomists, biologists, clinicians, computer scientists, mathematicians, theoretical and medical physicists, and philosophers of science.

 Awards & Honors:
  • 2019 Dean's Teacher Merit Honor Roll
  • 2019 Outstanding Teacher Selected by the Class of 2022
  • 2018 Dean's Teacher Merit Honor Roll
  • 2018 Outstanding Teacher Selected by the Class of 2021
  • 2017 Dean's Teacher Merit Honor Roll
  • 2017 Outstanding Teacher Selected by the Class of 2020
  • 2014 Finalist, Postdoc Poster Presentation Award
  • 2012 Best Oral Presentation
  • 2011 William H. Gates Award for Teaching Excellence
  • 2010 Induction as Associate Member
  • 2006 West Fund Grant
 Education:
  • PhD Louisiana State University
  • M.A. Louisiana State University
  • BA University of Nevada, Las Vegas
 Grants:
  • Codon Usage in Morbilliviruses: Evidence for Evolutionary Conservation & Importance for Adaptation to New Hosts, University of Georgia, $40,931.00
  • Realistic and Testable Models in Comparative Anatomy: Creative Uses of 3D/4D Imaging Techniques, American Association of Anatomists, $3,000.00
  • Development of Models for the Pathomechanical Analysis of Equine Navicular Disease, Charles V. Cusimano Equine Health Studies Program, $9,900.00
  • Teaching Enhancement Fund Travel Award, LSU Office of Academic Affairs, $500.00
 Publications:
Journal Article, Academic Journal:
  • Improvement of Tribological and Biocompatibility Properties of Orthopedic Materials Using Piezoelectric Direct Discharge Plasma Surface Modification, Chaichi, A; Lijesh, K; Prasad, A; Ettefagh, A; Shaik, S; Dasa, V; Guo, S; Osborn, Michelle; Devireddy, R; Khonsari, M; Gartia, M, 2019, ACS Biomaterials Science & Engineering , Volume: 5, Pages: 2147-2159
  • Indocyanine Green-assisted Dental Imaging in the First and Second Near-Infrared Windows as Compared with X-ray Imaging, Yao, Shaomian; Osborn, Michelle; Li, Zhongqiang; Ramirez, Alexandra; Hartzler, T; Xu, Jian; Zaid, W, 2019, Annals of the New York Academy of Sciences: Marrow , Volume: 1448, Pages: 42-51
  • The Human Shoulder Suspension Apparatus: A Causal Explanation for Bilateral Asymmetry and a Fresh Look at the Evolution of Human Bipedality, Osborn, Michelle; Homberger, Dominique , 2015, The Anatomical Record , Volume: 298, Number: 9, Pages: 1572-1588
  • A registration algorithm for the identification of individual parrots based on the patterns of filing ridges on their upper bill tip, Redd, Corey; Dubansky, Brooke ; Osborn, Michelle; Tully, Thomas; Homberger, Dominique, 2012, International Journal of Biology and Biometrics , Volume: 6, Number: 3, Pages: 68-91
Scientific Abstract:
  • Creating a 3D Model to Study Equine Lameness, Osborn, Michelle; Lee, Alexander; Uhl, Elizabeth, 2019
  • Synonymous Changes in Specific Leucine Codons Impact Morbilliviral Protein Production from Human & Canine Codon Optimized Constructs, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert; Jelesijevic, Tomislav, 2019
  • The Role and Power of 3D Models in Functional Morphology: A Tool for Generating Hypotheses, Capturing Conceptualizations, Enriching Explanations, and Facilitating Communication, Osborn, Michelle; Wood, Bradley; Daigle, C; Sonnier, B; Homberger, Dominique, 2019
  • Using Biotensegrity to Explain the Mechanically-Induced Lesions in Navicular Disease, Osborn, Michelle; Blas-Machado, Uriel; Kirejczyk, Shannon; Uhl, Elizabeth, 2019
  • Correlating Increased Mechanical Forces with Tissue Lesions in Equine Navicular Disease, Osborn, Michelle; Blas-Machado, Uriel; Uhl, Elizabeth; Kirejczyk, Shannon, 2018
  • Localized Optimization of Measles Virus (MV) Hemagglutinin (H) Gene to Human Codon Usage Bias Increases Protein Expression, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert; Jelesijevic, Tomislav, 2018
  • Protein Expression from Measles (MV) L Protein Genes Optimized and Suboptimized to Human and Canine Codon Usage Bias Varies with Construct and Cell Type, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert; Shah, Akash, 2018
  • The role of enthesis organs in degenerative joint disease: a structural and functional comparison of the human Achilles and equine navicular apparatus, Osborn, Michelle; Blas-Machado, Uriel; Uhl, Elizabeth, 2017
  • Free-body Diagram Force Analysis in 2D and 3D: A Tool to Study Comparative Vertebrate Biomechanics, Osborn, Michelle; Ge, Jinghua; Rau, A. Ravi; Homberger, Dominique, 2017
  • Analysis of Forces Acting on the Equine Navicular Bone in Normal and Dorsiflexed Positions, Ruff, Kaitlyn; Osborn, Michelle; Uhl, Elizabeth , 2016
  • Human Achilles and Equine Navicular Apparatus: A Structural and Functional Comparison of Two Premier Enthesis Organs, Osborn, Michelle; Blas-Machado, Uriel; Uhl, Elizabeth , 2016
  • Synonymous Codon Changes in Measles (HMV) and Canine Distemper (CDV) Viral Nucleic Acid Sequences Result in Gene-Specific Changes in Levels of Viral Protein Expression, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert, 2016
  • Human & Canine Codon Optimization of Measles & Canine Distemper Viral Nucleic Acid Sequences Increases Sequence Identity and Protein Expression Compared to Wild Type and Human Codon Sub-optimized Constructs, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert, 2015
  • Male vs. Female Horse Riders: Differences in Musculoskeletal Response to the Force Generated by a Horse at the Trot, Osborn, Michelle; Cornille, Jean Luc; Uhl, Elizabeth , 2015
  • Effects of the curvature of the lumbar spine on the posture of male and female horse riders: A biomechanical analysis, Osborn, Michelle; Cornille, Jean Luc; Uhl, Elizabeth , 2014
  • Optimization of the nucleocapsid (N) protein sequences of human measles virus (HMV) and canine distemper virus (CDV) to human and canine codon usage bias increases sequence identity and protein expression, Uhl, Elizabeth; Osborn, Michelle; Michel, Frank; Hogan, Robert, 2014
  • The effect of posture on the neck and shoulder suspension apparatus of humans: A 3D biomechanical analysis, Osborn, Michelle; Ge, Jinghua; Melancon, Keith; Rau, A. Ravi; Homberger, Dominique, 2013
  • Comparative functional morphology of the head suspension of quadrupedal cats and the shoulder suspension of bipedal humans, Osborn, Michelle; Homberger, Dominique, 2012
  • Biomechanical analysis of the human head-neck-shoulder complex: Asymmetry as a natural experiment, Osborn, Michelle; Homberger, Dominique, 2011
  • The human head-neck-shoulder complex: A configuration to free the hands, Osborn, Michelle; Homberger, Dominique, 2011
  • The function and evolution of the mastoid process and clavicle in humans: A natural experiment, Osborn, Michelle; Homberger, Dominique, 2010
Written Case with Instructional Material:
  • The Pathomechanics of Degenerative Joint Disease: A One Health Comparative Case Study Approach, Uhl, Elizabeth ; Osborn, Michelle, 2016