Dr. Muzammel Haque
Pathobiological Sciences (PBS)
Biography:
B.S. in Animal Science
M.S. in Animal Breeding from Bangladesh Agricultural University.
Ph.D. in molecular virology, Osaka University School of Medicine, Japan
Post-doc National Institutes of Health, Bethesda, Maryland
Teaching Interests:
Molecular Virology and pathogenesis caused by different human and animal
herpesviruses.
Research Interests:
My primary responsibility is to manage the BIOMMED protein core protein facility supported by LBRN, LUNG COBRE & cancer COBRE. To produce protein and antibody and reagents needed for faculty research projects and train students in the use of SPR in protein interaction study. Another areas of research focus on studying the differential regulations of hypoxia inducible factors (HIFs) by Kaposi’s sarcoma-associated herpesvirus (KSHV). HIFs are transcription factors which constitutes two subunits (HIF-1 alpha & HIF-2 alpha). Increasing evidence demonstrated that hypoxia and hypoxia inducible factors (HIFs) play important roles in the KSHV life cycles. Recent research reveals that while some genes of KSHV have been shown to interact and negatively regulated HIFs alpha dependent gene transcription other genes have been shown to stabilizes HIFs alpha protein. Specific areas of interest include studying the rules of some key genes of KSHV that differentially regulates HIF-alpha proteins.
Others areas of research interest include studying the molecular virology of bovine herperpesvirus type-1 to generate improve vaccines by manipulating the viral genome using Bacterial Artificial Chromosome (BAC) and Crispr cas-9 technology.