Dr. Muzammel Haque
Pathobiological Sciences (PBS)

Biography:
B.S. in Animal Science
M.S. in Animal Breeding from Bangladesh Agricultural University.
Ph.D. in molecular virology, Osaka University School of Medicine, Japan
Post-doc National Institutes of Health, Bethesda, Maryland

Teaching Interests:
Molecular Virology and pathogenesis caused by different human and animal
herpesviruses.

Research Interests:
My primary responsibility is to manage the BIOMMED protein core protein facility supported by LBRN, LUNG COBRE & cancer COBRE. To produce protein and antibody and reagents needed for faculty research projects and train students in the use of SPR in protein interaction study. Another areas of research focus on studying the differential regulations of hypoxia inducible factors (HIFs) by Kaposi’s sarcoma-associated herpesvirus (KSHV). HIFs are transcription factors which constitutes two subunits (HIF-1 alpha & HIF-2 alpha). Increasing evidence demonstrated that hypoxia and hypoxia inducible factors (HIFs) play important roles in the KSHV life cycles. Recent research reveals that while some genes of KSHV have been shown to interact and negatively regulated HIFs alpha dependent gene transcription other genes have been shown to stabilizes HIFs alpha protein. Specific areas of interest include studying the rules of some key genes of KSHV that differentially regulates HIF-alpha proteins.
Others areas of research interest include studying the molecular virology of bovine herperpesvirus type-1 to generate improve vaccines by manipulating the viral genome using Bacterial Artificial Chromosome (BAC) and Crispr cas-9 technology.

 Grants:
  • Assessment Of The Bovine Ocular Microbiome For Therapeutic Targets In Disease States, USDA, $200,000.00
 Publications:
Scientific Abstract:
  • Ex vivo modeling of bovine herpesvirus-1 keratitis and cidofovir antiviral treatment, Alling, Christopher; Liu, Chin-Chi ; Langohr, Ingeborg; Haque, Muzammel; Carter, Renee; Baker, Rose; Lewin, Andrew, 2021
Journal Article, Academic Journal:
  • Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Thymidine Kinase (ORF21) by X-Box Binding Protein 1., Wang, V; Davis, D; Deleage, C; Brands, C; Choi, H; Haque, Muzammel; Yarchoan, R, 2020, Journal of virology , Volume: 94, Number: 5
  • The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains., Haque, Muzammel; Kousoulas, Konstantin, 2019, Journal of virology , Volume: 93, Number: 17
  • A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses., Liu, S; Haque, Muzammel; Stanfield, Brent; Andrews, Frank; Roy, Alma; Kousoulas, Konstantin, 2017, Veterinary microbiology , Volume: 198, Pages: 51-58
  • Bovine herpesvirus type-1 glycoprotein K (gK) interacts with UL20 and is required for infectious virus production., Haque, Muzammel; Stanfield, Brent; Kousoulas, Konstantin, 2016, Virology , Volume: 499, Pages: 156-164
  • Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses., Davis, D; Naiman, N; Wang, V; Shrestha, P; Haque, Muzammel; Hu, D; Anagho, H; Carey, R; Davidoff, K; Yarchoan, R, 2015, PLoS pathogens , Volume: 11, Number: 7, Pages: e1005064
  • The Kaposi's sarcoma-associated herpesvirus ORF34 protein binds to HIF-1α and causes its degradation via the proteasome pathway., Haque, Muzammel; Kousoulas, Konstantin, 2013, Journal of virology , Volume: 87, Number: 4, Pages: 2164-73
  • Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors., Veeranna, R; Haque, Muzammel; Davis, D; Yang, M; Yarchoan, R, 2012, Journal of virology , Volume: 86, Number: 2, Pages: 1097-108