Dr. Kui Yang
Pathobiological Sciences (PBS)
Herpes simplex virus (HSV) is an important human pathogen, infecting up to 90% of the global population, classically causing oral and genital mucocutaneous vesicular lesions (e.g. fever blisters, cold sores). Other more severe clinical manifestations of HSV infection include encephalitis, meningitis and keratitis. As an obligate intracellular pathogen, HSV relies on host-cell functions for most aspects of its replication cycle, however, the involvement of host factors in HSV replication is poorly understood. Understanding the complex interplay between host factors and viral proteins will not only advance our knowledge of HSV infection and pathogenesis but also provide targets for the development of essential clinical interventions. My research goal is to identify new drug targets and develop novel anti-HSV therapies. My current research interests are (i) Identifying host factors essential for HSV replication through high-throughput CRISPR/Cas9 sgRNA library screening, (ii) studying the mechanism of how host factors affect HSV replication, and (iii) identifying drug targets and developing new anti-viral therapies.