Dr. Andrea Johnston
Assistant Professor
Veterinary Clinical Sciences (VCS)
(225) 578-9600

Biography:
Dr. Johnston grew up in Hopkinton, MA. She earned her B.S. in Microbiology and Veterinary Sciences from the University of Arizona and her D.V.M. from Tufts University School of Veterinary Medicine. She completed her residency in Small Animal Internal Medicine at Cornell and earned her Ph.D. in Molecular Biology from UT Southwestern in Dallas.


Teaching Interests:
Hepatobiliary disease

Research Interests:
Hepatobiliary disease, cancer, cell signaling pathways

 Awards & Honors:
  • 2020 Dean's teaching honor roll
  • 2019 Dean's teaching honor roll
 Education:
  • PhD UT Southwestern Medical Center
  • DVM Tufts University School of Veterinary Medicine
  • BS University of Arizona
 Grants:
  • Defining the hepatic metabolic and inflammatory transcriptional markers of mid to late-gestation in BPH/5 and C57Bl/6 mice, VCS CORP, $4,000.00
  • Evaluation of biliary anatomy and bile composition in bearded dragons (Pogona vitticeps) using ultrasound guided, computed tomographic cholecystography., VCS CORPS , $4,000.00
  • Tumor Necrosis Factor Mediated Cell Death in Canine Cells: A Novel Signaling Pathway, SVM CORP, $10,000.00
  • Targeted transcriptome characterization of canine hepatobiliary neuroendocrine tumors, VCS CORP Grant , $4,000.00
  • Establishing minimally invasive markers of hepatic fibrosis, VCS CORP Grant , $4,000.00
  • Evaluation of Differential Gene Expression in the canine FGF19 Signaling Pathway, LSU Summer Scholars: LSU, Boehringer Ingelheim Foundation grant, and a NIH T35 training grant, $6,211.00
  • Base editing the feline PKD1 gene, SVM CORP, $7,500.00
  • The preeclampsia-like BPH/5 mouse: A murine model of preeclampsia induced liver dysfunction?, VCS CORP, $4,000.00
  • Hepatocyte ploidy in cats with and without hepatocellular carcinoma, LSU Summer Scholars: LSU, Boehringer Ingelheim Foundation grant, and a NIH T35 training grant, $6,211.00
  • Quantification of pre-prandial and post-prandial serum FGF19 in dogs , CGS/IDEXX Veterinary Student Summer Scholar Award, $8,000.00
 Publications:
Journal Article, Academic Journal:
  • HSP70 promotes MLKL polymerization and necroptosis., Johnston, Andrea; Wang, Z, 2020, Molecular & cellular oncology , Volume: 7, Number: 5, Pages: 1791561
  • Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis., Johnston, Andrea; Ma, Y; Liu, H; Liu, S; Hanna-Addams, S; Chen, S; Chen, C; Wang, Z, 2020, Proceedings of the National Academy of Sciences of the United States of America , Volume: 117, Number: 12, Pages: 6521-6530
  • Necroptosis: MLKL Polymerization., Johnston, Andrea, 2018, J Nat Sci , Volume: 4, Number: 7
  • MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis, Liu, Shuzhen; Liu, Hua; Johnston, Andrea; Hanna-Addams, Sarah; Reynoso, Eduardo; Xiang, Yougui; Wang, Zhigao, 2017, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Volume: 114, Number: 36, Pages: E7450-E7459
  • Clinical findings, diagnostics and outcome in 33 cats with adrenal neoplasia (2002-2013), Daniel, Gideon; Mahony, Orla; Markovich, Jessica; Appleman, Elizabeth; Monaghan, Kelly; Lawrence, Yuri; Fiocchi, E.; Weaver, Kelli; Johnston, Andrea; Barton, Bruce, 2016, JOURNAL OF FELINE MEDICINE AND SURGERY , Volume: 18, Number: 2, Pages: 77-84
  • Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs., Davignon, D; Lee, A; Johnston, Andrea; Bowman, D; Simpson, K, 2016, The Journal of small animal practice , Volume: 57, Number: 3, Pages: 148-58
  • Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes., Webster, C; Johnston, Andrea; Anwer, M, 2014, American journal of physiology. Gastrointestinal and liver physiology , Volume: 307, Number: 12, Pages: G1207-15
  • Hypoperfusion and acute traumatic coagulopathy in severely traumatized canine patients, Abelson, Amanda; O'Toole, Therese; Johnston, Andrea; Respess, Meghan, 2013, JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE , Volume: 23, Number: 4, Pages: 395-401
  • Hepatic copper concentrations in Labrador Retrievers with and without chronic hepatitis: 72 cases (1980-2010)., Johnston, Andrea; Center, S; McDonough, S; Wakshlag, J; Warner, K, 2013, Journal of the American Veterinary Medical Association , Volume: 242, Number: 3, Pages: 372-80
  • cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase., Johnston, Andrea; Ponzetti, K; Anwer, M; Webster, C, 2011, American journal of physiology. Gastrointestinal and liver physiology , Volume: 301, Number: 2, Pages: G385-400
  • Portal hypertension: pathophysiology, diagnosis, and treatment., Buob, S; Johnston, Andrea; Webster, C, 2011, Journal of veterinary internal medicine , Volume: 25, Number: 2, Pages: 169-86