Dr. J. Michael Mathis
Comparative Biomedical Sciences (CBS)

Department Head leading twenty faculty, four administrative staff, and two research cores. We conduct basic and translational research in diverse areas including cancer biology, cardiovascular disease, developmental biology, neurosciences, and toxicology.

Teaching Interests:
cellular and molecular biology, physiology, histology

Research Interests:
adenovirus-based gene therapy, oncolytic virotherapy, and immunotherapy of cancer; cancer biomarkers; cancer therapeutics; molecular imaging

 Awards & Honors:
  • 2017 Phi Kappa Phi
  • EdD University of Alabama
  • Sabbatical Res Stanford University
  • MHA Louisiana State University in Shreveport
  • Sabbatical Res Univ of Alabama at Birmingham
  • Postdoctoral Fellow Univ of California, San Diego
  • PhD Univ of Texas Southwestern Med Center
  • BS Texas A&M University
  • Novel MicroRNA based therapeutic approaches to suppress breast tumor growth using SPECT imaging, Louisiana Biomedical Collaborative Research Program, $25,000.00
  • Targeted-and Image-Based Adenovirus Cancer Therapeutic Vectors , National Institutes of Health, $135,000.00
Journal Article, Academic Journal:
  • IL27 controls skin tumorigenesis via accumulation of ETAR-positive CD11b cells in the pre-malignant skin., Dibra, D; Mitra, A; Newman, M; Xia, X; Keenan, C; Cutrera, J; Mathis, J. Michael; Wang, X; Myers, J; Li , S, 2016, Oncotarget , Volume: 7, Number: 47, Pages: 77138-77151
  • CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter., Bhatia, S; O'Bryan, S; Rivera, A; Curiel, D; Mathis, J. Michael, 2016, Oncolytic virotherapy , Volume: 5, Pages: 99-113
  • Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting., Siurala, M; Vähä-Koskela, M; Havunen, R; Tähtinen, S; Bramante, S; Parviainen, S; Mathis, J. Michael; Kanerva, A; Hemminki, A, 2016, Oncoimmunology , Volume: 5, Number: 5, Pages: e1136046
  • Characterization of an oncolytic adenovirus vector constructed to target the cMet receptor, Sakr, H; Coleman, D; Cardelli, J; Mathis, J. Michael, 2015, Oncolytic Virotherapy , Volume: 4, Pages: 119-132
  • Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates., Jackson, K; Dayton, R; Fisher-Perkins, J; Didier, P; Baker, K; Weimer, M; Gutierrez, A; Cain, C; Mathis, J. Michael; Gitcho, M; Bunnell, B; Klein, R, 2015, Journal of medical primatology , Volume: 44, Number: 2, Pages: 66-75
  • Construction and radiolabeling of adenovirus variants that incorporate human metallothionein into protein IX for analysis of biodistribution., Liu, L; Rogers, B; Aladyshkina, N; Cheng, B; Lokitz, S; Curiel, D; Mathis, J. Michael, 2014, Molecular imaging , Volume: 13
  • VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy, Cromer, W.; Ganta, C.; Patel, M.; Traylor, J.; Kevil, C.; Alexander, J.; Mathis, J. Michael, 2013, J Transl Med , Volume: 11, Number: 1, Pages: 207
  • A recombinant inhibitory isoform of vascular endothelial growth factor164/165 aggravates ischemic brain damage in a mouse model of focal cerebral ischemia, Chaitanya, G.; Cromer, W.; Parker, C.; Couraud, P.; Romero, I.; Weksler, B.; Mathis, J. Michael; Minagar, A.; Alexander, J., 2013, Am. J. Pathol. , Volume: 183, Number: 3, Pages: 1010–1024
  • Quantification of bone changes in a collagen-induced arthritis mouse model by reconstructed three dimensional micro-CT, Yang, S.; Hollister, A.; Orchard, E.; Chaudhery, S.; Ostanin, D.; Lokitz, S.; Mathis, J. Michael, 2013, Biol Proced Online , Volume: 15, Number: 1, Pages: 8
  • Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis, Dayton, R.; Gitcho, M.; Orchard, E.; Wilson, J.; Wang, D.; Cain, C.; Johnson, J.; Zhang, Y.; Petrucelli, L.; Mathis, J. Michael; Klein, R., 2013, Mol. Ther. , Volume: 21, Number: 7, Pages: 1324–1334
  • Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy, Ronald, S.; Awate, S.; Rath, A.; Carroll, J.; Galiano, F.; Dwyer, D.; Kleiner-Hancock, H.; Mathis, J. Michael; Vigod, S.; De Benedetti, A., 2013, Genes Cancer , Volume: 4, Number: 1-2, Pages: 39–53
  • Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector, Williams, B.; Bhatia, S.; Adams, L.; Boling, S.; Carroll, J.; Li, X.; Rogers, D.; Korokhov, N.; Kovesdi, I.; Pereboev, A.; Curiel, D.; Mathis, J. Michael, 2012, PLoS ONE , Volume: 7, Number: 10, Pages: e46981
  • Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice, Batra, V.; Syed, Z.; Gill, J.; Coburn, M.; Adegboyega, P.; DiGiovanni, J.; Mathis, J. Michael; Shi, R.; Clifford, J.; Kleiner-Hancock, H., 2012, J. Exp. Clin. Cancer Res. , Volume: 31, Pages: 57
  • PET imaging a MPTP-induced mouse model of Parkinson’s disease using the fluoropropyl-dihydrotetrabenazine analog [18F]-DTBZ (AV-133), Toomey, J.; Bhatia, S.; Moon, L.; Orchard, E.; Tainter, K.; Lokitz, S.; Terry, T.; Mathis, J. Michael; Penman, A., 2012, PLoS ONE , Volume: 7, Number: 6, Pages: e39041
  • Virotherapy using a novel chimeric oncolytic adenovirus prolongs survival in a human pancreatic cancer xenograft model, Chu, Q.; Sun, G.; Pope, M.; Luraguiz, N.; Curiel, D.; Kim, R.; Li, B.; Mathis, J. Michael, 2012, Surgery , Volume: 152, Number: 3, Pages: 441–448
  • Metabolic modulation of cytokine-induced brain endothelial adhesion molecule expression, Chaitanya, G.; Cromer, W.; Wells, S.; Jennings, M.; Mathis, J. Michael; Minagar, A.; Alexander, J., 2012, Microcirculation , Volume: 19, Number: 2, Pages: 155–165
  • Establishment of a mammary carcinoma cell line from Syrian hamsters treated with N-methyl-N-nitrosourea, Coburn, M.; Brueggemann, S.; Bhatia, S.; Cheng, B.; Li, B.; Li, X.; Luraguiz, N.; Maxuitenko, Y.; Orchard, E.; Zhang, S.; Stoff-Khalili, M.; Mathis, J. Michael; Kleiner-Hancock, H., 2011, Cancer Lett. , Volume: 312, Number: 1, Pages: 82–90
  • Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging, Mathis, J. Michael; Bhatia, S.; Khandelwal, A.; Kovesdi, I.; Lokitz, S.; Odaka, Y.; Takalkar, A.; Terry, T.; Curiel, D., 2011, PLoS ONE , Volume: 6, Number: 2, Pages: e16792
  • Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro, Chaitanya, G.; Cromer, W.; Wells, S.; Jennings, M.; Couraud, P.; Romero, I.; Weksler, B.; Erdreich-Epstein, A.; Mathis, J. Michael; Minagar, A.; Alexander, J., 2011, J Neuroinflammation , Volume: 8, Pages: 162
  • Role of the endothelium in inflammatory bowel diseases, Cromer, W.; Mathis, J. Michael; Granger, D.; Chaitanya, G.; Alexander, J., 2011, World J. Gastroenterol. , Volume: 17, Number: 5, Pages: 578–593
  • Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts, Kleiner-Hancock, H.; Shi, R.; Remeika, A.; Robbins, D.; Prince, M.; Gill, J.; Syed, Z.; Adegboyega, P.; Mathis, J. Michael; Clifford, J., 2010, BMC Cancer , Volume: 10, Pages: 394
  • Association of core-binding factor β with the malignant phenotype of prostate and ovarian cancer cells, Davis, J.; Rogers, D.; Adams, L.; Yong, T.; Jung, J.; Cheng, B.; Fennell, K.; Borazanci, E.; Moustafa, Y.; Sun, A.; Shi, R.; Glass, J.; Mathis, J. Michael; Williams, B.; Meyers, S., 2010, J. Cell. Physiol. , Volume: 225, Number: 3, Pages: 875–887
  • Murine rVEGF164b, an inhibitory VEGF reduces VEGF-A-dependent endothelial proliferation and barrier dysfunction, Cromer, W.; Jennings, M.; Odaka, Y.; Mathis, J. Michael; Alexander, J., 2010, Microcirculation , Volume: 17, Number: 7, Pages: 536–547
  • The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses, Pennington, K.; Chu, Q.; Curiel, D.; Li, B.; Mathis, J. Michael, 2010, J. Surg. Res. , Volume: 163, Number: 2, Pages: 270–275
  • Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro, Chaitanya, G.; Franks, S.; Cromer, W.; Wells, S.; Bienkowska, M.; Jennings, M.; Ruddell, A.; Ando, T.; Wang, Y.; Gu, Y.; Sapp, M.; Mathis, J. Michael; Jordan, P.; Minagar, A.; Alexander, J., 2010, Lymphat Res Biol , Volume: 8, Number: 3, Pages: 155–164
  • Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy, Short, J.; Rivera, A.; Wu, H.; Walter, M.; Yamamoto, M.; Mathis, J. Michael; Curiel, D., 2010, Mol. Cancer Ther. , Volume: 9, Number: 9, Pages: 2536–2544
  • Angiopoietin-2 in experimental colitis, Ganta, V.; Cromer, W.; Mills, G.; Traylor, J.; Jennings, M.; Daley, S.; Clark, B.; Mathis, J. Michael; Bernas, M.; Boktor, M.; Jordan, P.; Witte, M.; Alexander, J., 2010, Inflamm. Bowel Dis. , Volume: 16, Number: 6, Pages: 1029–1039
  • Genetic modification of mesenchymal stem cells to express a single-chain antibody against EGFRvIII on the cell surface, Balyasnikova, I.; Franco-Gou, R.; Mathis, J. Michael; Lesniak, M., 2010, J Tissue Eng Regen Med , Volume: 4, Number: 4, Pages: 247–258
Scientific Abstract:
  • Targeting an Oncolytic Adenovirus to Cancer Cells Using the Chemokine Ligand CXCL12, O'Bryan, Samia; Mathis, J, 2017
  • A Single Fiber Surface Enhanced Raman Scattering (SERS) Probe, Basu, S; Hou, HC; Biswas, T; Daniels-Race, Theda; Lopez, Mandi; Mathis, J. Michael; Feldman, Martin, 2017
Journal Article, Professional Journal:
  • A needle probe to detect surface enhanced raman scattering (SERS) within solid specimens, Basu, S; Hou, H; Biswas, D; Maulik, S; Daniels-Race, Theda; Lopez, Mandi; Mathis, J. Michael; Feldman, Martin, 2017, Rev Sci Instrum , Volume: 88, Number: 2
  • A needle probe to detect surface enhanced raman scattering (SERS) within solid specimens, Basu, S; Hou, H; Biswas, D; Daniels-Race, Theda; Lopez, Mandi; Mathis, J. Michael; Feldman, Martin, 2017, Review of Scientific Instruments , Volume: 88, Number: 2
  • The roles of oncogenic miRNAs and their therapeutic importance in breast cancer, O'Bryan, Samia; Dong, Shengli; Mathis, J. Michael; Alahari, Suresh, 2017, European Journal of Cancer , Volume: 72, Pages: 1-11