skip to main content
.edu
myLSU
Directories
Give
Visit
Apply
Employment
Contact Us
Go!
School of Veterinary Medicine
School of Veterinary Medicine
Menu
About
Dean's Welcome
Accreditation
Administration
Contact Us
Location
History
Diversity
Faculty Pages
Apply
DVM Admissions
MS/PhD Admissions
Internships and Residencies
Employment Opportunities
Departments
Comparative Biomedical Sciences
Pathobiological Sciences
Veterinary Clinical Sciences
Diversity
Research and Advanced Studies
Student Affairs
Veterinary Medicine Library
Veterinary Teaching Hospital
LADDL
Alumni
Alumni Resources
Alumni Activities
Keep in Touch
Employment Opportunities
Distinguished Alumnus Award
Alumni Giving
Continuing Education
Folder Review
Hospital/Services
Veterinary Teaching Hospital
Emergencies
Wildlife Hospital
Shelter Medicine
Teleradiology Service
Counseling Services
BIOMMED
Flow Cytometry Core Facility
Lab Animal Medicine
LA Animal Disease Diagnostic Lab
Microscopy Center
Veterinary Medicine Library
Disaster Preparedness
One Health
Community Outreach
News/Events
Continuing Education
Events
Community Outreach
News Releases
Our Stories
La Veterinaire
SVM Update (e-newsletter)
Annual Bulletin (catalog)
Advancement Report
Research Report
Equine Research Report
Wildlife Hospital newsletter
Research
Research and Advancied Studies
BIOMMED
COBRE
Equine Health Studies Program
Flow Cytometry Core Facility
Division of Lab Animal Medicine
LECOR
Microscopy Center
Small Animal Imaging Facility
Veterinary Endocrine and Metabolic Disease Lab
LSU Sponsored Programs
Statistical Services Unit
Student Research
Veterinary Medicine Library
Initiative for Maximizing Student Development
One Health
Resources
Student
Employee
Visitors and Veterinarians
Jobs
Employment at SVM
Employment around U.S.
Give
Dr. Joseph Francis
Professor
Comparative Biomedical Sciences (CBS)
jfrancis@lsu.edu
Awards & Honors:
2015 Dean's Teacher Merit Honor Roll
2012 Dean's Teacher Merit Honor Roll
2009 Arthur Guyton Young Investigator Award
Grants:
Effect of a Whole blueberry powder consumption on Chronic kidney disese with diabetic nephropathy: A randomized double-blind placebo-controlled study, Blueberry Growers of America, $248,000.00
Effect of Whole Blueberry Powder Consumption on Depression: A Randomized Double Blind Placebo Controlled Study, Blueberry Growers of America, $188,000.00
AHA, AHA, $170,000.00
NHLBI, NIH,
Exploring beneficial effects of blueberries in horses: Effect of blueberries on Exercise Testing in horses on the Treadmill, Blueberry Growers of America, $62,208.00
Grant, AHA, $170,000.00
Grant, USHBBC, $110,000.00
Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular Cells in the Hypothalamus, NIH NHLBI R01 HL115208-01A1, $1.00
CBS Seed Grant, CBS, $10,000.00
The Effects of Flight Stress on an Animal Model of PTSD, Air Force Clinical Research Laboratory, Keesler AFB, $90,000.00
Inflammation, Oxidative Stress, and Neuroprotective Mechanisms in the Pathophysiology of PTSD in an Animal Model: Blueberries and Exercise as Possible Therapeutic Approaches. , Department of Defense, $225,000.00
Role of blueberries in modulating neurotransmitter and SKA2 (suicide) gene in animal model of PTSD, US High Bush Blueberry Council, $110,000.00
The Effects of Toxoplasmosis During the Progression of Post-Traumatic Stress Disorder in a Predator Exposure Animal Model. , Air Force Military Support Agency (AFMSA) , $50,000.00
NIHNHLBI, NIH,
LSU-SVM Corp, LSU-SVM Corp,
USHBBC, USHBBC,
Inflammation, oxidative stress and Neuroprotective factors in the pathophysiology of Post Traumatic Stress Disorder in Rat Model exposed to stressors of Flight, Kessler Air Force Base - Mississippi, $86,085.00
Publications:
Journal Article, Academic Journal:
Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension, J, X; Miao, YW; Li, HB; Su, Q; Liu, KL; Fu, LY; Hou, YK; Shi, XL; Li, Y; Mu, JJ; Chen, WS; Cui, W; Zhu, GQ; Ebenzer, PJ; Francis, Joseph; Kang, YM, 2019, Neuroscience Bulletin , Volume: 35, Pages: 47-56
Current and future functional imaging techniques for post traumatic stress disorder, Prasad, A; Kelley, P; Francis, Joseph; Gartia, MR, 2019, RSC Adv. , Volume: 9, Pages: 24568-24594
A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation., Ogundele, O; Pardo, J; Francis, Joseph; Goya, R; Lee, Charles, 2018, Frontiers in neuroanatomy , Volume: 12, Pages: 35
A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation, Ogundele, Olalekan; Pardo, Joaquin; Francis, Joseph; Goya, Rodolfo; Lee, Charles, 2018, Frontiers in Neuroanatomy , Volume: 12, Pages: 35
Influence of Myocardial Hemorrhage on Staging of Reperfused Myocardial Infarctions With T2 Cardiac Magnetic Resonance Imaging: Insights Into the Dependence on Infarction Type With Ex Vivo Validation., Wang, G; Yang, HJ; Kali, A; Cokic, I; Tang, R; Xie, G; Yang, Q; Francis, Joseph; Li, S; Dharmakumar, R, 2018, JACC Cardiovascular Imaging , Volume: pii: S1936-878X(18)30128-1. doi:10.1016/j.jcmg.2018.01.018 [Epub ahead of print] PMID:29680356
Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double blinded study., Nair, AR; Mariappan, N; Francis, Joseph; Lee, CC, 2017, Food and Function , Volume: 8 , Number: 11, Pages: 4118-4128
Systemic sympathoexcitation was associated with paraventricular hypothalamic phosphorylation of synaptic CaMKIIα and MAPK/ErK, Ogundele , Olalekan; Rosa, Fernando; Lee, Charles; Francis, Joseph; Dharmakumar, Rohan, 2017, Frontiers in Neuroscience , Volume: 11, Pages: 447
Thalamic dopaminergic neurons project to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, The Anatomical Record , Volume: 300, Number: 7, Pages: 1307-1314
Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy, Ogundele , Olalekan; Ebenezer, Philip; Lee, Charles; Francis, Joseph, 2017, Neuroscience , Volume: 353, Pages: 147-165
Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor (IGF1-R) as a possible link between sympathoexcitation and inflammation, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2016, Journal of Neurochemistry , Volume: 139, Number: 5, Pages: 706-721
The Anti-inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD), Ebenezer, Philip; Nair, Anand; Wilson, Brad; McLaughlin, Leslie; Francis, Joseph, 2016, PLoS ONE , Volume: 11(9), Number: e0160923
The Anti-inflammatory effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder, Ebenezer, Philip; Wilson, C; Wilson, Leslie; Nair, Anand; Francis, Joseph, 2016, PLoS
Therapeutic potential of adipose stem cells derived conditioned medium against pulmonary hypertension and lung fibrosis., Rathinasabapathy, Kwon; Lin, S; Kin, G; Son, C; Shi, P; Nair, Anand; Francis, Joseph; Katovich, Michael; Shenoy, Vinayak; Raizada, Mohan, 2016, British Journal of Pharmacology
AngiotensinII-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubuloepithelial cells, Nair, Anand; Ebenezer, Philip; Saini, Yogesh; Francis, Joseph, 2015, Experimental Cell Research , Volume: 335, Number: 2, Pages: 238-47
Role of TLR4 in Lipopolysaccharide-induced Acute Kidney Injury: Protection by Blueberry, Nair, Anand; Masson, Gustavo; Francis, Joseph; Ebenezer, Philip; Del Piero, Fabio, 2014, Free Radical Biology & Medicine , Volume: 71C, Pages: 16-25
Role of TLR4 in lipopolysaccharide-induced acute kidney injury: protection by blueberry., Nair, A; Masson, G; Ebenezer, P; Del Piero, Fabio; Francis, Joseph, 2014, Free radical biology & medicine , Volume: 71, Pages: 16-25
Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension , Dange, Rahul; Agarwal, Deepmala; Francis, Joseph; Masson, Gustavo; Villa, Jorge; Wilson, Brad; Nair, Anand, 2014, Cardiovascular Research
Role of TLR4 in lipopolysaccharide-induced acute kidney injury: Protection by blueberry., Nair, A; Masson, G; Ebenezer, P; Del Piero, Fabio; Francis, Joseph, 2014, Free radical biology & medicine , Volume: 71C, Pages: 16-25
Predator Exposure/Psychosocial Stress Animal Model of Post-Traumatic Stress Disorder Modulates Neurotransmitters in the Rat Hippocampus and Prefrontal Cortex, Wilson, Leslie; Wilson, C; Ebenezer, Philip; Francis, Joseph, 2014, PLOS ONE , Volume: 9, Number: 2, Pages: 7
Predator Exposure/Psychosocial Stress Animal Model of Post-Traumatic Stress Disorder Modulates Neurotransmitters in the Rat Hippocampous and Prefrontal Cortex, Wilson, Brad; Francis, Joseph; Ebenezer, Philip; Wilson, Leslie; Nair, Anand, 2014, PLoS One
A blueberry-enriched diet improves renal function and reduces oxidative stress in metabolic syndrome animals: potential mechanism of TLR4-MAPK signaling pathway., Nair, A; Elks, C; Vila, J; Del Piero, Fabio; Paulsen, Daniel; Francis, Joseph, 2014, PloS one , Volume: 9, Number: 11, Pages: e111976
Diaminazene Attenuates pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models, Shenoy, Vinayak; Gjymishka, Altin; Francis, Joseph; Yagna, Jarajapu; Qi, Yanfei; Afzal, Aqeela; Rigatto, Katya; Ferreira, Anderson; Fraga-Silva, Rodrigo; Kearns, Patrick; Yellowlees Douglas, Jane; Agarwal, Deepmala; Mubarak, Kamal; Bradford, Chastity; Kennedy, William; Jun, Joo; Rathinasabapathy, Anandharajan; Bruce, Erin; Gupta, Dipankar; Cardounel, Arturo; Mocco, J; Patel, Jawaharlal; Grant, Maria; Katovich, Michael; Raizada, Mohan, 2013, American Journal of Respiratory and Critical Care Medicine , Volume: 187(6):648-57
The Role of ER Stress in Renal Diseases in Metabolic Syndrome Animals: Blockade by Natural Antioxidants, Nair, A; Francis, Joseph, 2013, Hypertension , Number: 62:A215
(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells, Peng, Hua; lI, Wencheng ; Francis, Joseph; Seth, Dale; Nair, Anand; Feng, Yumei, 2013, PLoS One , Volume: 8(3), Number: e58339
Bioactives in Fruit: Health benefits and functional foods, Shukitt-Hale, Barbara; Elks, Carrie; Francis, Joseph; Stull, April; Cefalu, William; Ingram, Donald, 2013, Wiley Online Publisher
Inflammation and Oxidative Stress are Elevated in the Brain, Blood, and Adrenal Glands During the Progresion of Post-Traumatic Stress DIsorder in a Predator Exposure Animal Model, Francis, Joseph; Wilson, Brad; Wilson, Leslie; Nair, Anand; Ebenezer, Philip; Dange, Rahul, 2013, PLoS One , Volume: 9(10), Number: e76146
Inhibitions of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension, Sriramula, Srinivas; Cardinale, Jeffrey; Francis, Joseph, 2013, PLoS One , Volume: 8(5), Number: e63847
Inflammation and Oxidative Stress Are Elevated in the Brain, Blood, and Adrenal Glands during the Progression of Post-Traumatic Stress Disorder in a Predator Exposure Animal Model , Wilson, Leslie; Wilson, Carl; Nair, Anand; Ebenezer, Philip ; Dange, Rahul; Francis, Joseph, 2013, PLoS One , Volume: 8, Number: 10, Pages: 10
Bilateral ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced blood pressure response, Francis, Joseph; Sriramula, S; Cardinale, J; Lazartigue, E, 2012, Journal of Cardiovascular , Volume: 92(3), Number: 401-8
Detraining Differentially Preserved Beneficial Effects of Exercise on Hypertension: Effects on Blood Pressure, Cardiac Function, Brain Infalmmatory Cytokines and Oxidative Stress., Francis, Joseph, 2012, PLoS One
Vasoreactivity before and after hand grip training in chronic heart failure patients., Francis, Joseph; Credeur, Daniel; Mariappan, Nithya; Thomas, David; Moraes, Denzil; Welsch, Michael, 2012, Atherosclerosis
Obesity increases cerebrocortical reactive exygen species and impairs brain function., Francis, Joseph; Freeman, LR; Zhang, L; Nair, A; Dasuri, K, 2012, Free Radical Biology and Medicine
Interaction of TNF with Angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats., Francis, Joseph; Mariappan, Mithya; Elks, Carrie; Villa, Jorge, 2012, PLoS One
Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR., Francis, Joseph; Agarwal, Deepmala; Welsch, Michael; Keller, Jeffrey ; Francis, Joseph, 2011, Basic Research in Cardiology , Volume: 106, Number: 6, Pages: 1069-85, 2011
Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide, Francis, Joseph; Guggiluam, Anuradha; Cardinale, Jeffrey; Mariappan, Nithya; Sriramula, Srinivas, 2011, Basic Research in Cardiology , Volume: 106(2), Pages: 273-286
Brain Microglial Cytokines in Hypertension., Francis, Joseph; Shi, Peng; Diez-Freire, Carlos; Yun Jun, Joo; Qi, Yanfei; Katovich, Michael ; Li, Qiuhong; Sriramula, Srinivas; Sumners, Colin; Raizada, Mohan, 2010, Hypertension
Central adiposity, Systemic Inflammation and the Metabolic Syndrome., Francis, Joseph; Elks, Carrie, 2010, Current Hypertension Report , Volume: 12, Number: 2
HDAC inhibition attenuates hypertensive and hypertrophic response elements in left ventricle of spontanesously hypertensive rats, Pariaut, Romain; Cardinale, Jeffrey; Sriramula, S; Guggilam, Anurhada; Mariappan, N; Francis, Joseph, 2010, Hypertension , Volume: 56, Number: 3, Pages: 437-444
Involvement of tumor necrosis factor-alpha in the natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anexthetized mice., Francis, Joseph; Shahid, M; Matrougui, K; Majid, DS, 2010, Am J Physiol Renal Physiol
NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes., Francis, Joseph; Mariappan, N; Elks, CM; Sriramula, S; Guggilam, A; Liu, Z; Borkhsenious, O, 2010, Cariovasc Res , Volume: 85, Number: 3, Pages: 473-83
Journal Article, Professional Journal:
Psychological effect of rapid aero-medical evacuation in a predator exposure animal model of posttraumatic stress disorder, Wilson, Brad; Harre, Joseph ; Shaak, Thomas ; Wilson, Leslie; Francis, Joseph, 2016, Military Medicine , Number: 181(11)
Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder. , Wilson, C; Wilson, Leslie; Ebenezer, P; Nair, A; Dange, R; Harre, J; Shaak, T; Diamond, D; Francis, Joseph, 2014, Frontiers in Behavioral Neuroscience
Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats, Mariappan, Nithya; Agarwal, Deepmala; Elks, Carrie; Reed, Scott; Majid, Dewan; Francis, Joseph, 2012, Antioxid Redox Signal , Volume: 16, Number: 2, Pages: 139-152
Oxidative stress and interaction of endothelin receptors in airways of clinically healthy horses, Venugopal, Changaram; Mariappan, Nithya; Holmes, Earnestine; Koch, Catherine; Francis, Joseph; Eades, Susan, 2011, Journal of Equine Veterinary Science , Volume: 31, Pages: 1-6
The angiotensin converting enzyme 2/Angiognesis-(1-7)/Mas axis fonfers cardiopulmonary protection against drug fibrosis and pulmonary hypertension., Venugopal, Changaram; Shenoy, Vijay; Ferreira, AJ; Qi, Y; Fraga-Silva, RA; Doez-Freire, C; Dooles, A; Yun Dun, D; Sriamula, Srinivasan; Maiappan, Nithya; Pourang, D; Francis, Joseph; Reudelhuber, T; Santos, RA; Patel, JM; Raizada, Mohan; Katovich, MJ, 2010, American Critical Care Medicine , Volume: 182, Number: 8, Pages: 1065-1072
Scientific Abstract:
Angiotensin II-induced ER stress in the heart is attenuated by exercise, Masson, G; Nair, A; Francis, Joseph; White, M; Agarwal, D, 2013
Blueberry treatment improves renal function and reduces oxidative stress in Metabolic syndrome animals - Role of Toll-like receptor 4 (TLR4), Nair, A; Francis, Joseph; Vila, J; Piero, F, 2013
Central blockade of TLR4 improves cardiac function and attenuates pro-inflammatory cytokines and oxidative stress in hypertensive rats, Dange, Rahul; Francis, Joseph; Agarwal, Deepmala; Vila, Jorge; Wilson, Brad; Teruyama, Ryoichi, 2013
Exercise training attenuates ER stress in the kidney cortex and improves renal function in the Angiotensin II-induced hypertensive rats, Nair, A; Masson, G; Francis, Joseph; Ebenezer, P, 2013
Expression of (pro)renin receptor and antiotensin II type 1 receptor on bone marrow-related neurons in the central nervous system, Kimball, Christie; Francis, Joseph; Li, Wencheng; Zsombok, Andrea ; Derbenev, Andrei; Raizada, Mohan; Feng, Yumei, 2013
Glycogen synthase kinase - 3 beta inhibition in the PVN attenuates hypertensive response: Role of inflammation, Agarwal, D; Cardinale, J; Francis, Joseph; Sriramula, S; Dange, R; Nair, A, 2013
Inflammation, Oxidative stress, and Neuroprotective factors in the pathophysiology of PTSD in a predator exposure animal model, Wilson, B; Francis, Joseph; Wilson, Leslie; Nair, A; Dange, R; Ebenezer, P, 2013
Mice Lacking the Gene for Toll-like Receptor 4 (TLR4) Had an Attenuated ER Stress in the Heart in Response to Ang II Infusion , Dange, R; Nair, A; Francis, Joseph; Vila, J, 2013
NLRP3 inflammasomes is activated in the kidneys of metabolic syndrome animals, Nair, A; Francis, Joseph; Wilson, B, 2013
Role of central GSK-3β in mediating exercise-induced improvement in inflammatory cytokines and reduction in blood pressure in hypertensive rates, Agarwal, Deepmala; Dange, Rahul; Francis, Joseph, 2013
This website uses cookies to ensure site visitors get the best experience on our website. By continuing to use this site, you accept our use of cookies and Privacy Statement. To learn more, please visit
LSU Privacy Statement.
I Accept
©