Dr. Samithamby ("Jey") Jeyaseelan
Director
Professor
Pathobiological Sciences (PBS)

Biography:
Dr. Jeyaseelan ("Jey"), Veterinarian-Scientist (DVM/PhD), is an internationally recognized investigator in the area of innate immunity against pathogens as it relates to inflammation and injury in the lungs and extrapulmonary organs. His educational interest primarily focuses on training the next generation of veterinarian-scientists and scientists interested in inflammation, infectious disease and innate immunity. He is the Dr. William L. Jenkins Endowed Professor and the Director of the NIH-funded Center for Lung Biology and Disease.

Teaching Interests:
Dr. Jey is actively involved in teaching of Veterinary Medical students in Bacteriology, Mycology and Immunology, and Graduate students in Advanced Immunology and Infectious Disease.

Research Interests:
Research in the Center for Lung Biology and Disease (CLBD) investigates lung inflammation and pulmonary host defense against bacterial pathogens. The overall research goal of the CLBD is to understand the molecular and cellular mechanisms responsible for neutrophil recruitment, priming, and activation in infected lungs, smoke-exposed lungs, and smoke-exposed lungs and organs followed by infection in the lungs and other organs/tissues. In particular, the LBL is interested in determining the role of pattern recognition receptors (TLRs and NLRs) and their adaptors with the development of the innate immune response in the lung in murine models. Multiple bacterial pathogens that are studied include: Klebsiella pneumoniae, Streptococcus pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Legionella pneumophila, as causative pathogens of pneumonia. Specific interests of the respiratory disease group include: 1) Delineation of the role of pattern recognition receptors (Toll-like and NOD-like) and neutrophil chemokines, CXCL1, CXCL2, and CXCL5, in lung inflammation and host defense; 2) Elucidation of the mechanisms by which second-hand smoke makes the host susceptible to bacterial infection; 3) Determination of the host defense mechanisms associated with sepsis/septic peritonitis; and 4) Examination of the role of mouse lung-derived stem cells in host protection during bacterial pneumonia. Appropriate gene-deficient mice and human and murine primary cells are currently being used. In addition, non-human primate (NHP) models of bacterial lung infection are being developed with the collaboration of Tulane National Primate Center (TNPRC). The ultimate goal of the LBL basic and translation program is to resolve the mechanisms by which these bacterial pathogens cause inflammation in various tissues, and ultimately to design novel treatments and prevention strategies to attenuate inflammation-mediated injury and/or minimize microbial burden.

We are always interested in motivated new team members, including undergraduate students, graduate students, postdoctoral researchers and junior faculty [Asst Professors (Research)]
Research Interest Video
LSU Garners $11.5 M NIH grant to Establish Louisiana Pulmonary Center
NIH COBRE Award Video
Postdoctoral researcher wins AHA fellowship
Graduate student wins prestigious NIH fellowship
Undergraduate student wins multiple awards

 Awards & Honors:
  • 2019 Dr. William L. Jenkins Endowed Professorship
  • 2013 Dean's Teaching Merit Honor Roll
  • 2013 Distinguished Faculty Scholar Award
  • 2011 Pfizer Award for Research Excellence
  • 2002 James Hudson Brown – Alexander B. Coxe postdoctoral fellowship
  • 2001 Student Leadershio Award
  • 2000 Elizabeth Atac Award for Best Basic Science Research
  • 1999 Don Kahn Award in Immunology
 Education:
  • Postdoctoral Fellowship National Jewish Health
  • Brown-Coxe Postdoctoral Fellowship School of Medicine, Yale University
  • PhD College of Veterinary Medicine, University of Minnesota
  • MPhil (Master of Philosophy) Faculty of Medicine, University of Peradeniya
  • DVM Faculty of Veterinary Medicine, University of Peradeniya, Sri Lanka
 Grants:
  • Center for Lung Biology and Disease (Principal Investigator), NIH, $11,530,336.00
  • Innate Immunity in Lung Infection-Induced Sepsis (Principal Investigator), NIH, $2,927,440.00
  • Innate Immunity in Pneumonic Sepsis (Co-Investigator); PI: Shanshan Cai, NIH, $1,850,300.00
  • NLRP6 in Bacterial Pneumonia (Sponsor); PI: Liliang Jin, American Heart Association (AHA), $106,000.00
  • Role of Innate Immunity in Pneumonic Sepsis (Sponsor); PI; Sagar Paudel, NIH, $109,000.00
  • Role of Lung Mesenchymal Stem Cells in Pneumonia-Induced Sepsis (Principal Investigator), NIH, $407,000.00
  • Neutrophil Function in Bacterial Pneumonia (Principal Investigator), NIH, $1,858,300.00
  • CRC-specific near-IR agent for tumor imaging (Co-Investigator); PO: Graca Vicente, NIH, $1,256,000.00
  • NOD-Like Receptor Signaling is Critical to Secondhand Smoke-Induced Innate Immune Responses (Mentor), NIH, $542,500.00
  • Neutrophil Accumulation in Bacterial Pneumonia (Principal Investigator), NIH, $1,860,000.00
  • NALP6 Inflammasome is Critical to Cigarette Smoke-induced Airway Inflammation (Mentor), FAMRI, $525,500.00
  • Secondhand Smoke Promotes Antibiotic Resistance & Virulence in Upper Airway Bacteria: A Novel Mechanism for Secondhand SmokeInduced Airway Diseases (Mentor), FAMRI, $217,000.00
  • Suppression of Neutrophil Immunity by Smoke (Principal Investigator), FAMRI, $325,500.00
 Publications:
Journal Article, Academic Journal:
  • CXCL1 Regulates Neutrophil Homeostasis in Pneumonia-Derived Sepsis Caused by Streptococcus pneumoniae Serotype 3, Paudel, Sagar; Baral, Pankaj; Ghimire, Laxman; Bergeron, Scott; Jin, Liliang; DeCorte, Joseph; Lee, Joh; Cai, Shanshan; Jeyaseelan, Samithamby, 2019, Blood , Volume: x, Number: xx, Pages: xxxxxx
  • NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function, Ghimire, Laxman; Pauel, Sagar; Jin, Liliang; Baral, Pankaj; Cai, Shanshan; Jeyaseelan, Samithamby, 2018, PLoS Pathogens , Volume: 14, Number: 9, Pages: e1007308
  • NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia , Paudel, Sagar; Ghimire, Laxman; Jin, Liliang; Baral, Pankaj; Cai, Shanshan; Jeyaseelan, Samithamby, 2018, Mucosal Immunology , Pages: In Press
  • Emerging Roles of Inflammasomes in Acute Pneumonia, Ravi Kumar, Sangeetha; Jeyaseelan, Samithamby; Paudel, Sagar; Ghimire, Laxman; Bergeron, Scott; Cai, Shanshan; Zemans, Rachel; Downey, Gregory, 2018, American Journal of Respiratory and Critical Care Medicine , Volume: 197, Number: 2, Pages: 160-71
  • Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis, which can be rescued by CXCL1., Jin, Liliang; Batra, Sanjay; Jeyaseelan, Samithamby, 2017, PLoS Pathogens , Volume: 13, Pages: e1006637
  • Deletion of Nlrp3 Augments Survival During Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis. , Jin, Liliang; Batra, Sanjay; Jeyaseelan, Samithamby, 2016, Journal of immunology , Volume: 198, Pages: 1253-1262
  • Cigarette smoke extract-exposed MRSA regulates leukocyte function for pulmonary persistence, Kulkarni, Ritwij; Caskey, John; Singh, Sanjay ; Paudel, Sagar; Baral, Pankaj; Schexnayder, Matthew; Kim, J; Kim, N; Kosmider, Beata; Ratner, Adam; Jeyaseelan, Samithamby, 2016, American Journal of Respiratory Cell and Molecular Biology , Volume: 55, Pages: 586-601
  • IFN-g induction by neutrophil derived IL-17A homodimer augments pulmonary antibacterial defense, Cai, S; Batra, Sanjay; Langohr, Ingeborg; Jeyaseelan, Samithamby, 2016, Mucosal Immunology , Volume: 9, Number: 3, Pages: 719-729
  • NLRP12 modulates host defense through IL-17A-CXCL1 axis., Cai, S; Batra, Sanjay; Del Piero, Fabio; Jeyaseelan, Samithamby, 2016, Mucosal immunology , Volume: 9, Pages: 718-29
  • CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions, Jin, Liliang; Batra, Sanjay; Jeyaseelan, Samithamby, 2014, Journal of immunology
  • Divergent functions of Toll-like receptors during bacterial lung infections., Baral, Pankaj; Batra, Sanjay; Jeyaseelan, Samithamby, 2014, American Journal of Respiratory and Critical Care Medicine
  • Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection, Leissinger, Mary; Batra, Sanjay; Jeyaseelan, Samithamby, 2014, American Journal of Respiratory and Critical Care Medicine
  • Intrapulmonary G-CSF Reverses Neutrophil Recruitment to the Lung and Neutrophil Release to Blood to Gram-negative Bacterial Infection in MCP-1-/- Mice, Jeyaseelan, Samithamby; Batra, Sanjay; Douda, David; Palaniyar, Nades; Jin, Liliang, 2014, Journal of Immunology , Volume: 193, Pages: 3549-58
  • NLRC4 inflammasome-mediated production of IL-1 β modulates mucosal immunity in the lung against Gram-negative bacterial infection, Wakamatsu, Nobuko; Cai, S; Batra, Sanjay; Pacher, P; Jeyaseelan, Samithamby, 2012, Journal of Immunology , Volume: 188, Pages: 5623-5635
  • Intrapulmonary G-CSF Reverses Neutrophil Recruitment to the Lung and Neutrophil Release to Blood to Gram-negative Bacterial Infection in MCP-1-/- Mice, Patcher, Pal; Jeyaseelan, Samithamby; Batra, Sanjay; Balamayooran, Theivanthiran; Cai, Shanshan; Balamayooran, Gayathriy; Jeyaseelan, Samithamby, 2012, Journal of Immunology , Volume: 188, Pages: 5623-35
  • Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice, Kobayashi, Koichi; Jeyaseelan, Samithamby; Cai, Shanshan; Balamayooran, Gayathriy; Jeyaseelan, Samithamby; Batra, Sanjay; Flavell, Richard, 2012, Journal of Immunology , Volume: 188, Number: 07, Pages: 3458-68
  • Role of CXCL5 in leukocyte recruitment to the lungs during second-hand smoke exposure, Balamayooran, G; Batra, S; Mei, J; Worthen, S; Penn, Arthur; Jeyaseelan, S, 2012, American Journal of Respiratory Cell and Molecular Biology , Volume: 47, Pages: 104-11
  • Role of CXCL5 in Leukocyte Recruitment to the Lungs During Secondhand Smoke Exposure, Kobayashi, Koichi; Jeyaseelan, Samithamby; Batra, Sanjay; Balamayooran, Gayathriy; Cai, Shanshan; Balamayooran, Theivanthiran; Flavell, Richard, 2012, Infection and Immunity , Volume: 80, Pages: 2558-69
  • Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A, Kobayashi, Koichi; Jeyaseelan, Samithamby; Batra, Sanjay; Balamayooran, Gayathriy; Cai, Shanshan; Balamayooran, Theivanthiran; Flavell, Richard, 2011, Infection and Immunity , Volume: 79, Pages: 4588-99
  • Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection, Jeyaseelan, Samithamby; Batra, Sanjay; Balamayooran, Theivanthiran; Cai, Shanshan; Balamayooran, Gayathriy, 2011, Infection and Immunity , Volume: 79, Pages: 2567-77
  • CXCL1 regulates pulmonary host defense to Klebsiella Infection via CXCL2, CXCL5, NF-kappaB, and MAPKs., Jeyaseelan, Samithamby; Batra, Sanjay; Lira, Sergio; Kolls, Jay; Cai, Shanshan, 2010, Journal of Immunology , Volume: 185, Number: 10, Pages: 6214-25
  • CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection, Jeyaseelan, Samithamby; Mei, Junjie; Liu, Yuhong; Dai, Ning; Favara, Michael; Greene, Teshell; Mortimer, Poncz; Lee, Janel; Worthen, G, 2010, Immunity , Volume: 33, Pages: 106-17
  • Review: Toll-like receptors and NOD-like receptors in pulmonary antibacterial immunity, Jeyaseelan, Samithamby; Balamayooran, Theivanthiran; Balamayooran, Gayathriy, 2010, Innate Immunity , Volume: 16, Number: 3, Pages: 201-10
Editorial:
  • Aiding and abetting the enemy: Nicotine impairs macrophage defense against Mtb., Kulkarni, Ritwij; Jeyaseelan, Samithamby, 2017
  • Strangers with Candy: Polishing the Lungs with C-type Lectins., Jeyaseelan, Samithamby; Kulkarni, Ritwij, 2013
  • Comment on "innate immune collectin surfactant protein d simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping"., Jeyaseelan, Samithamby, 2012
Letter to the Editor:
  • Comment on "nonhematopoietic cells are key players in innate control of bacterial airway infection", Jeyaseelan, Samithamby, 2011
  • Bacteria: the silent killer during flu pandemics?, Jeyaseelan, Samithamby, 2010