Dr. Samithamby ("Jey") Jeyaseelan
Pathobiological Sciences (PBS)
Dr. Jeyaseelan ("Jey"), Veterinarian-Scientist (DVM/PhD), is an internationally recognized investigator in the area of innate immunity against pathogens as it relates to inflammation and injury in the lungs and extrapulmonary organs. His educational interest primarily focuses on training the next generation of veterinarian-scientists and scientists interested in inflammation, infectious disease and innate immunity. He is the Dr. William L. Jenkins Endowed Professor and the Director of the NIH-funded Center for Lung Biology and Disease.
Dr. Jey is actively involved in teaching of Veterinary Medical students in Bacteriology, Mycology and Immunology, and Graduate students in Advanced Immunology and Infectious Disease.
Research in the Center for Lung Biology and Disease (CLBD) investigates lung inflammation and pulmonary host defense against bacterial pathogens.
The overall research goal of the CLBD is to understand the molecular and cellular mechanisms responsible for neutrophil recruitment, priming, and activation in infected lungs, smoke-exposed lungs, and smoke-exposed lungs and organs followed by infection in the lungs and other organs/tissues.
In particular, the LBL is interested in determining the role of pattern recognition receptors (TLRs and NLRs) and their adaptors with the development of the innate immune response in the lung in murine models.
Multiple bacterial pathogens that are studied include: Klebsiella pneumoniae, Streptococcus pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Legionella pneumophila, as causative pathogens of pneumonia.
Specific interests of the respiratory disease group include: 1) Delineation of the role of pattern recognition receptors (Toll-like and NOD-like) and neutrophil chemokines, CXCL1, CXCL2, and CXCL5, in lung inflammation and host defense;
2) Elucidation of the mechanisms by which second-hand smoke makes the host susceptible to bacterial infection; 3) Determination of the host defense mechanisms associated with sepsis/septic peritonitis;
and 4) Examination of the role of mouse lung-derived stem cells in host protection during bacterial pneumonia. Appropriate gene-deficient mice and human and murine primary cells are currently being used.
In addition, non-human primate (NHP) models of bacterial lung infection are being developed with the collaboration of Tulane National Primate Center (TNPRC).
The ultimate goal of the LBL basic and translation program is to resolve the mechanisms by which these bacterial pathogens cause inflammation in various tissues,
and ultimately to design novel treatments and prevention strategies to attenuate inflammation-mediated injury and/or minimize microbial burden.
We are always interested in motivated new team members, including undergraduate students, graduate students, postdoctoral researchers and junior faculty [Asst Professors (Research)]
Research Interest Video
LSU Garners $11.5 M NIH grant to Establish Louisiana Pulmonary Center
NIH COBRE Award Video
Postdoctoral researcher wins AHA fellowship
Graduate student wins prestigious NIH fellowship
Undergraduate student wins multiple awards