Dr. Joel Baines
Pathobiological Sciences (PBS)

 Awards & Honors:
  • 2020 Teaching honor Roll
  • 2019 Jacobs Professor of Excellence Award
  • 1994 Phi Zeta Veterinary Honor Fraternity
  • 1979 Magna Cum Laude
  • 1979 Phi Kapa Phi Honor Society
 Education:
  • PhD Cornell University
  • VMD VMD University of Pennsylvania
  • BS Kansas State University
 Grants:
  • Center for Pre-Clinical Disease Research , National Institutes of Health - NIH, $11,192,691.00
  • How herpes simplex virus repurposes RNA polymerase II for its own transcription, National Institutes of Health, $1,850,000.00
  • RNA Polymerase II occupance and activity in a model of HSV latency and reactivation, National Institutes of Health, $370,000.00
 Publications:
Journal Article, Academic Journal:
  • The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor, Farkas, Tibor; Yang, Kui; Baines, Joel; Cardin, Rhonda, 2019, JOURNAL OF VIROLOGY , Volume: 93, Number: 22
  • Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection, Birkenheuer, Claire; Danko, Charles; Baines, Joel, 2018, JOURNAL OF VIROLOGY , Volume: 92, Number: 8
  • The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression, Pennington, Matthew; Callaway, Heather; Dehghanpir, Shannon; Baines, Joel; Parrish, Colin, 2018, JOURNAL OF VIROLOGY , Volume: 92, Number: 20
  • Broad anti-herpesviral activity of α-hydroxytropolones., Dehghanpir, Shannon; Birkenheuer, C; Yang, Kui; Murelli, R; Morrison, L; Baines, Joel, 2018, Veterinary microbiology , Volume: 214, Pages: 125-131
  • Exploring the Balance between DNA Pressure and Capsid Stability in Herpesviruses and Phages., Bauer, D; Li , D; Huffman, J; Homa, F; Wilson, K; Leavitt, J; Casjens, S; Baines, Joel; Evilevitch, A, 2015, Journal of virology , Volume: 89, Number: 18, Pages: 9288-98
  • A mutation in the DNA polymerase accessory factor of herpes simplex virus 1 restores viral DNA replication in the presence of raltegravir., Zhou, B; Yang, K; Wills, E; Tang, L; Baines, Joel, 2014, Journal of virology , Volume: 88, Number: 19, Pages: 11121-9
  • Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex-specific complex., Yang, K; Wills, E; Lim, H; Zhou, Z; Baines, Joel, 2014, Journal of virology , Volume: 88, Number: 7, Pages: 3815-25
  • The herpes simplex virus 1 UL51 gene product has cell type-specific functions in cell-to-cell spread., Roller, R; Haugo, A; Yang, K; Baines, Joel, 2014, Journal of virology , Volume: 88, Number: 8, Pages: 4058-68
  • A herpes simplex virus scaffold peptide that binds the portal vertex inhibits early steps in viral replication., Yang, K; Wills, E; Baines, Joel, 2013, Journal of virology , Volume: 87, Number: 12, Pages: 6876-87
  • The structure of the herpes simplex virus DNA-packaging terminase pUL15 nuclease domain suggests an evolutionary lineage among eukaryotic and prokaryotic viruses., Selvarajan Sigamani, S; Zhao, H; Kamau, Y; Baines, Joel; Tang, L, 2013, Journal of virology , Volume: 87, Number: 12, Pages: 7140-8
  • The herpes simplex virus 2 UL21 protein is essential for virus propagation., Le Sage, V; Jung, M; Alter, J; Wills, E; Johnston, S; Kawaguchi, Y; Baines, Joel; Banfield, B, 2013, Journal of virology , Volume: 87, Number: 10, Pages: 5904-15
  • Release of the herpes simplex virus 1 protease by self cleavage is required for proper conformation of the portal vertex., Yang, K; Wills, E; Baines, Joel, 2012, Virology , Volume: 429, Number: 1, Pages: 63-73
  • Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle., Mbong, E; Woodley, L; Frost, E; Baines, Joel; Duffy, C, 2012, Journal of virology , Volume: 86, Number: 12, Pages: 7003-7
  • Herpes simplex virus capsid assembly and DNA packaging: a present and future antiviral drug target., Baines, Joel, 2011, Trends in microbiology , Volume: 19, Number: 12, Pages: 606-13
  • A mutation in UL15 of herpes simplex virus 1 that reduces packaging of cleaved genomes., Yang, K; Wills, E; Baines, Joel, 2011, Journal of virology , Volume: 85, Number: 22, Pages: 11972-80
  • Selection of HSV capsids for envelopment involves interaction between capsid surface components pUL31, pUL17, and pUL25., Yang, K; Baines, Joel, 2011, Proceedings of the National Academy of Sciences of the United States of America , Volume: 108, Number: 34, Pages: 14276-81
  • Herpesviruses remodel host membranes for virus egress., Johnson, D; Baines, Joel, 2011, Nature reviews. Microbiology , Volume: 9, Number: 5, Pages: 382-94
  • UL31 of herpes simplex virus 1 is necessary for optimal NF-kappaB activation and expression of viral gene products., Roberts, K; Baines, Joel, 2011, Journal of virology , Volume: 85, Number: 10, Pages: 4947-53
  • Actin in herpesvirus infection., Roberts, K; Baines, Joel, 2011, Viruses , Volume: 3, Number: 4, Pages: 336-46
  • Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses., Iyer, A; Morales, J; Huang, W; Ojo, F; Ning, G; Wills, E; Baines, Joel; August, A, 2011, The Journal of biological chemistry , Volume: 286, Number: 11, Pages: 9503-13
  • Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses., Iyer, A; Morales, J; Huang, Weishan; Ojo, F; Ning, G; Wills, E; Baines, Joel; August, A, 2011, The Journal of biological chemistry , Volume: 286, Number: 11, Pages: 9503-13
  • Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins., Roberts, K; Baines, Joel, 2010, Journal of virology , Volume: 84, Number: 19, Pages: 9889-96
  • The capsid protein encoded by U(L)17 of herpes simplex virus 1 interacts with tegument protein VP13/14., Scholtes, L; Yang, K; Li , L; Baines, Joel, 2010, Journal of virology , Volume: 84, Number: 15, Pages: 7642-50