Dr. Weishan Huang
Assistant Professor
Pathobiological Sciences (PBS)

 Awards & Honors:
  • 2018 AAI Travel For Techniques Award
  • 2018 AAI European Congress of Immunology Travel Award
  • 2018 Faculty Scholarship, Summer Institute on the Future of Graduate Studies at LSU
  • 2018 AAI Early Career Faculty Travel Grant
 Education:
  • PhD Cornell University
 Grants:
  • TCR signaling in IL-10 production by CD8+ T cells during influenza-induced lung immunopathology, NIH/NIGMS: LSU-Center for Lung Biology and Disease,
  • GCN2 signaling in pathogenic and regulatory T cell development in allergic airway inflammation, NIH/NIAID,
  • A novel murine model of allergic airway inflammation, NIH/NIAID,
  • Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammation, NIH/NIAID,
  • ITK signaling in type 2 innate lymphoid cell-mediated pulmonary inflammation and fibrosis, LSU-SVM, Competitive Research Program (CORP),
  • T cell signals in immune balance and host survival during T. gondii infection, NIH/NIGMS: LSU-Tulane Center for Experimental Infectious Disease and Research,
 Publications:
Journal Article, Academic Journal:
  • HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2., Cao, J; Sun, L; Aramsangtienchai, P; Spiegelman, N; Zhang, X; Huang, Weishan; Seto, E; Lin, H, 2019, Proceedings of the National Academy of Sciences of the United States of America
  • Thymic regulatory T cells arise via two distinct developmental programs., Owen, D; Mahmud, S; Sjaastad, L; Williams, J; Spanier, J; Simeonov, D; Ruscher, R; Huang, Weishan; Proekt, I; Miller, C; Hekim, C; Jeschke, J; Aggarwal, P; Broeckel, U; LaRue, R; Henzler, C; Alegre, M; Anderson, M; August, A; Marson, A; Zheng, Y; Williams, C; Farrar, M, 2019, Nature immunology , Volume: 20, Number: 2, Pages: 195-205
  • Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages., Huang, Weishan; Solouki, S; Carter, C; Zheng, S; August, A, 2018, Frontiers in immunology , Volume: 9, Pages: 2625
  • Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy., Battu, S; Afroz, S; Giddaluru, J; Naz, S; Huang, Weishan; Khumukcham, S; Khan, R; Bhat, S; Qureshi, I; Manavathi, B; Khan, A; August, A; Hasnain, S; Khan, N, 2018, PLoS biology , Volume: 16, Number: 4, Pages: e2005317
  • ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells., Huang, Weishan; Solouki, S; Koylass, N; Zheng, S; August, A, 2017, Nature communications , Volume: 8, Pages: 15871
  • T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk., Kannan, A; Mohinta, S; Huang, Weishan; Huang, L; Koylass, N; Appleton, J; August, A, 2017, Scientific reports , Volume: 7, Pages: 45935
  • The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy., Heyward, C; Sones, Jennifer; Lob, H; Yuen, L; Abbott, K; Huang, Weishan; Begun, Z; Butler, S; August, A; Leifer, C; Davisson, R, 2017, Journal of reproductive immunology , Volume: 120, Pages: 27-33
  • Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy., Purwada, A; Tian, Y; Huang, Weishan; Rohrbach, K; Deol, S; August, A; Singh, A, 2016, Advanced healthcare materials , Volume: 5, Number: 12, Pages: 1413-9
  • Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide., Huang, Weishan; Morales, J; Gazivoda, V; August, A, 2016, The Journal of allergy and clinical immunology , Volume: 137, Number: 4, Pages: 1197-1205
  • Role(s) of IL-2 inducible T cell kinase and Bruton's tyrosine kinase in mast cell response to lipopolysaccharide., Huang, Weishan; August, A, 2016, Genomics data , Volume: 8, Pages: 18-20
  • HUS1 regulates in vivo responses to genotoxic chemotherapies., Balmus, G; Lim, P; Oswald, A; Hume, K; Cassano, A; Pierre, J; Hill, A; Huang, Weishan; August, A; Stokol, T; Southard, T; Weiss, R, 2016, Oncogene , Volume: 35, Number: 5, Pages: 662-9
  • Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production., Kannan, A; Lee, Y; Qi, Q; Huang, Weishan; Jeong, A; Ohnigian, S; August, A, 2015, European journal of immunology , Volume: 45, Number: 8, Pages: 2276-85
  • Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses., Law, M; Lee, Y; Morales, J; Ning, G; Huang, Weishan; Pabon, J; Kannan, A; Jeong, A; Wood, A; Carter, C; Mohinta, S; Song, J; August, A, 2015, Journal of immunology (Baltimore, Md. : 1950) , Volume: 195, Number: 2, Pages: 426-30
  • Cutting edge: STAT6 signaling in eosinophils is necessary for development of allergic airway inflammation., Stokes, K; LaMarche, N; Islam, N; Wood, A; Huang, Weishan; August, A, 2015, Journal of immunology (Baltimore, Md. : 1950) , Volume: 194, Number: 6, Pages: 2477-81
  • The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation., Huang, Weishan; August, A, 2015, Journal of leukocyte biology , Volume: 97, Number: 3, Pages: 477-85
  • The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection., Huang, F; Huang, Weishan; Briggs, J; Chew, T; Bai, Y; Deol, S; August, A, 2015, Scientific reports , Volume: 5, Pages: 7688
  • IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function., Huang, Weishan; Jeong, A; Kannan, A; Huang, L; August, A, 2014, Journal of immunology (Baltimore, Md. : 1950) , Volume: 193, Number: 5, Pages: 2267-72
  • ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner., Huang, Weishan; Huang, F; Kannan, A; Hu, J; August, A, 2014, Journal of leukocyte biology , Volume: 96, Number: 1, Pages: 55-63
  • Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation., Huang, Weishan; Qi, Q; Hu, J; Huang, F; Laufer, T; August, A, 2014, Journal of immunology (Baltimore, Md. : 1950) , Volume: 192, Number: 7, Pages: 3435-3441
  • The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor., Huang, Weishan; Morales, J; Gazivoda, V; Lai, J; Qi, Q; August, A, 2013, The international journal of biochemistry & cell biology , Volume: 45, Number: 6, Pages: 1074-82
  • Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase., Tse, L; Marcano, V; Huang, Weishan; Pocwierz, M; Whittaker, G, 2013, Journal of virology , Volume: 87, Number: 9, Pages: 5161-9
  • Cutting edge: innate memory CD8+ T cells are distinct from homeostatic expanded CD8+ T cells and rapidly respond to primary antigenic stimuli., Huang, Weishan; Hu, J; August, A, 2013, Journal of immunology (Baltimore, Md. : 1950) , Volume: 190, Number: 6, Pages: 2490-4
  • Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells., Kannan, A; Huang, Weishan; Huang, F; August, A, 2012, The international journal of biochemistry & cell biology , Volume: 44, Number: 12, Pages: 2129-34
  • A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice., Qi, Q; Huang, Weishan; Bai, Y; Balmus, G; Weiss, R; August, A, 2012, Journal of immunology (Baltimore, Md. : 1950) , Volume: 188, Number: 8, Pages: 3611-9
  • Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses., Iyer, A; Morales, J; Huang, Weishan; Ojo, F; Ning, G; Wills, E; Baines, Joel; August, A, 2011, The Journal of biological chemistry , Volume: 286, Number: 11, Pages: 9503-13
Other:
  • Editorial: Jack of all trades? The versatility of IL-4 in CD8+ T cell polarity., Huang, Weishan; August, A, 2013