Dr. Henrique Cheng- LSU SVM Faculty

Dr. Henrique Cheng

Associate Professor

Comparative Biomedical Sciences (CBS)

Research Interests:
Our research is focused on the molecular mechanisms controlling stem cell differentiation (tissue regeneration) and insulin secretion from pancreatic beta cells (diabetes). Another area of interest is the molecular mechanisms controlling sperm cell activation and motility (fertility). For these studies, we utilize patch-clamp, real-time calcium imaging analysis in combination with molecular biology to elucidate the mechanisms controlling cellular function.

Awards & Honors:

2021 LSU Discover Symposium award (Hannah Guidry, Undergraduate student)
2021 Dean's Teacher Merit Honor Roll
2020 LSU Discover Symposium award (Hannah Guidry, Undergraduate student)
2020 Dean's Teacher Merit Honor Roll
2019 Dean's Teacher Merit Honor Roll
2018 Dean's Teacher Merit Honor Roll
2017 Dean's Teacher Merit Honor Roll
2016 1st place Phi Zeta Research Day award (Tanyawan Suantawee, PhD student)
2016 Dean's Teacher Merit Honor Roll
2016 LSU PhD Dissertation Award (Tran DN Tran)
2015 2nd place poster award presentation (Kelsie Stovall, DVM student)
2015 Dean's Teacher Merit Honor Roll
2014 PhD Dissertation Fellowship Award (Tran DN Tran)
2014 Dean's Teacher Merit Honor Roll
2013 3rd place poster award presentation(Amanda Cathey, DVM student)
2013 Dean's Teacher Merit Honor Roll
2012 Dean's Teacher Merit Honor Roll
2011 Dean's Teacher Merit Honor Roll
2011 Best M.S. Student Thesis Award
2009 1st place award basic science category (Piper Nelson)
2008 Phi Zeta Tau Chapter Induction

Education:

PhD Iowa State University
MS Iowa State University
DVM Faculdade de Ciencias Agrarias do Para

Grants:

Identification of a novel calcium channel in sperm cells, Louisiana State University, $10,000.00
Molecular fingerprinting of sperm cells for support of conservation efforts of imperiled live-bearing fishes, LSU-ACRES, $14,959.00
Mechanisms of Anthocyanin-enrich Riceberry Rice Extract (Oryza sativa L) on the Regulation of Nutrient Metabolisms and Adipogenesis, Dutsadi Phiphat Award, Bangkok, Thailand, $8,900.00
Mechanisms of Anthocyanin-enrich Riceberry Rice Extract (Oryza sativa L) on the Regulation of Nutrient Metabolisms and Adipogenesis, Dutsadi Phiphat Award, Bangkok, Thailand, $6,575.00
Bidirectional regulation of glucagon secretion by GLP-1 in diabetes, Louisiana State University, $10,000.00
Molecular fingerprinting of sperm cells for support of conservation efforts of imperiled live-bearing fishes, LSU-ACRES, $50,000.00
Development of a methodology for intracellular Ca2+ recording in sperm bundles from Xiphophorus hellerii, LSU-SVM,
Control of adipogenesis and glucose uptake by cyanidin in adipocytes , CBS Department - Bridging Award, $5,000.00
The role of golli protein in insulin secretion of pancreatic beta cells, LSU-SVM-CORP,
Control of insulin secretion by the flavonoid cyanidin for diabetes treatment, LSU-SVM CORP Grant, $9,000.00
Molecular Mechanism of Cyanidin in Pancreatic Beta Cells, Royal Golden Jubilee Thai Research Foundation, $5,480.00
Role of Transient Receptor Potential Melastatin 4 channel in tissue repair , NIH/NIDCR R03, $148,000.00
Teaching Enhancement Fund Application, Campus Federal Credit Union, Baton Rouge, LA, $700.00
Molecular Mechanism of the Myokine Irisin in Cardiomyoblasts, CBS Department - Bridging Award, $10,000.00
CBS Bridging Grant, SVM - CBS Department, $10,000.00
Reprogramming Ca2+ signals in rat dental follicle stem cells for bone regeneration , CBS Bridging Award, $10,000.00
Reprogramming Calcium Signals in Dental Follicle Stem Cells for Bone Regeneration, LSU-SVM CORP, $6,025.00
The protective effects of ferulic acid on monosaccharide and methylglyoxal mediated glycation in BSA, DNA and pancreatic beta cells, Royal Golden Jubilee Thai Research Foundation, $6,482.98
Role of anti-diuretic hormone in stem cells, LSU-SVM CORP , $10,000.00
Control of human adipocyte stem cell differentiation by the TRPM4 protein, LSU-SVM CORP, $10,000.00

Publications:
Research Report:

Anthocyanin-Enriched Riceberry Rice Extract Inhibits Cell Proliferation and Adipogenesis in 3T3-L1 Preadipocytes by Downregulating Adipogenic Transcription Factors and Their Targeting Genes, Kongthitilerd, Phutthida ; Cheng, Henrique, 2020
Cyanidin attenuates methylglyoxal-induced oxidative stress and apoptosis in INS-1 pancreatic b-cells by increasing glyoxalase-1 activity, Suantawee, Tanyawan ; Cheng, Henrique, 2020
Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC-IP3 pathway and intracellular Ca 2+ signaling., Stovall, Kelsie; Tran, Tran; Suantawee, Tanawan; Yao, Shaomian; Gimble, Jeffrey; Adisakwattana, Sirichai; Cheng, Henrique, 2020

Journal Article, Academic Journal:

Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC-IP3 pathway and intracellular Ca 2+ signaling., Stovall, K; Suantawee, T; Yao, Shaomian; Gimble, J; Adisakwattana, S; Cheng, Henrique, 2020, Journal of cellular physiology , Volume: 235, Number: 2, Pages: 1723-1732
Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival., Ngoc Tran, T; Stovall, K; Suantawee, T; Hu, Y; Yao, Shaomian; Yang, L; Adisakwattana, S; Cheng, Henrique, 2017, Cell proliferation , Volume: 50, Number: 5
Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels., Suantawee, T; Elazab, S; Hsu, W; Yao, Shaomian; Cheng, Henrique; Adisakwattana, S, 2017, Nutrients , Volume: 9, Number: 8
Transient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiation, Ngoc Tran, T; Zhang, H; Zolochevska, O; Figueiredo, M; Feng, J; Xiao, R; Yao, S; Penn, Arthur; Yang, L; Cheng, H, 2013, Stem Cells , Volume: 31, Number: 1, Pages: 167-177
Regulation of Ca(2+)-entry in pancreatic α-cell line by transient receptor potential melastatin 4 plays a vital role in glucagon release., Nelson, P; Zolochevska, O; Figueiredo, Marxa; Soliman, A; Hsu, W; Feng, Ji-Ming; Zhang, H; Cheng, Henrique, 2011, Molecular and Cellular Endocrinology , Volume: 335, Number: 2, Pages: 126-134
Transient Receptor Potential Melastatin Type 7 Channel Is Critical for the Survival of Bone Marrow Derived Mesenchymal Stem Cells, Cheng, Henrique; Feng, Ji-Ming; Figueiredo, Marxa, 2010, Stem Cells and Development , Volume: 19, Number: 9, Pages: 1393-1403

Journal Article, Professional Journal:

Alkalinization-induced Ca2+ influx for sperm activation and motility of viviparous fish , Cheng, Henrique, 2018, Biology of Reproduction , Volume: 99, Number: 6, Pages: 11
Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival. , Cheng, Henrique, 2017, Cell Proliferation , Volume: 50, Number: 5, Pages: 8
Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels. , Cheng, Henrique, 2017, Nutrients , Volume: 9, Number: 8
Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells, Cheng, Henrique, 2017, Journal of Physiology and Biochemistry , Volume: 73, Number: 1, Pages: 121–131
Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage, Cheng, Henrique, 2016, International Journal of Biological Macromolecules , Volume: 93, Number: A, Pages: 814–821
Irisin exerts dual effects on browning and adipogenesis of human white adipocytes, Cheng, Henrique, 2016, American Journal of Physiology - Endocrinology and Metabolism , Volume: 311, Number: 2, Pages: E530-41
Vasopressin-induced Ca2+ signals in human adipose-derived stem cells, Tran, Tran; Gimble, Jeffrey; Cheng, Henrique, 2016, Cell Calcium , Volume: 59, Number: 2-3, Pages: 135-9
Expression and functionality of transient receptor potential melastatin 4 (TRPM4) ion channels during development of the zebrafish , Cheng, Henrique; Ellis, Jayne; Kleinow, Kevin, 2015, Comp Biochem Physiol C Toxicol Pharmacol , Volume: 178, Pages: 33-44
Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts., Tran, Tran; Cheng, Henrique, 2015, PLOS ONE , Volume: 10, Number: 8
Protective Effects of Ferulic Acid on High Glucose-Induced Protein Glycation, Lipid Peroxidation, and Membrane Ion Pump Activity in Human Erythrocytes, Sompong, Weerachat ; Cheng, Henrique; Adisakwattana, Sirichai , 2015, PLOS ONE , Volume: 10, Number: 6
Arginine vasopressin inhibits adipogenesis in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2015, Molecular and Cellular Endocrinology , Volume: 406, Pages: 1-9
Histamine-induced Ca2+ signaling is mediated by TRPM4 channels in human adipose-derived stem cells, Tran, Tran; Yao, Shaomian; Cheng, Henrique, 2014, Biochemical Journal , Volume: 463, Number: 1, Pages: 123-134
A Comparative Study of Ferulic Acid on Different Monosaccharide-Mediated Protein Glycations and Oxidative Damage in Bovine Serum Albumin, Cheng, Henrique, 2013, Molecules , Volume: 18, Number: 11, Pages: 13886-13903
Effect of the Environmental Pollutant Hexachlorobenzene (HCB) on the Neuronal Differentiation of Mouse Embryonic Stem Cells, Cheng, Henrique, 2013, International Journal of Environmental Research and Public Health , Volume: 10, Number: 10, Pages: 5244-5256
Reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation , Cheng, Henrique, 2013, Journal of Cell Science , Volume: 126, Number: 16, Pages: 3638-3648
Effects of dietary supplementation with Lactobacillus pentosus PL11 on the growth performance and immune and antioxidant systems of Japanese eel Anguilla japonica challenged with Edwardsiella tada, Cheng, Henrique, 2013, Fish and Shellfish Immunology , Volume: 34, Number: 3, Pages: 756-761
All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons, Addae, C; Yi, X; Gernapudi, R; Cheng, Henrique; Musto, A; Martinez-Caballos, E, 2012, Differentiation , Volume: 83, Number: 5, Pages: 233-241
Comparative pharmacokinetics of orbafloxacin following a single intravenous or oral administration to healthy or diabetic rats, Gebru, E; Chang, Z; Cheng, Henrique; Lee, J; Kim, J; Park, S, 2011, Scandinavian Journal of Laboratory Animals , Volume: 38, Number: 2, Pages: 99-107
In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from Phellinus gilvus, Chang, Z; Gebru, E; Lee, S; Rhee, M; Kim, J; Cheng, Henrique; Park, S, 2011, Journal of Nutrition and Science Vitaminology , Volume: 57, Pages: 118-22
Role of NF-κB and MAPK pathways in Mycoplasma hyopneumoniae-induced inflammatory response in murine alveolar macrophage cell line., Damte, D; Lee, S; Hwang, M; Gebru, E; Choi, M; Lee, J; Cheng, Henrique; Park, S, 2011, New Zealand Veterinary Journal , Volume: 59, Pages: 185-190
Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice, Cheng, Henrique; Zhang, Y; Wolfe, S; Valencia, V ; Qian, K; Shen, L; Tang, Y; Hsu, W; Atkinson, M; Phillips, M, 2011, Molecular and Cellular Endocrinology , Volume: 345, Number: 1-2, Pages: 88-96
The role of Janus kinase 2 (JAK2) activation in pneumococcal EstA protein-induced inflammatory response in RAW 264.7 macrophages, Gebru, E; Kang, E; Damte, D; Lee, S; Jang, S; Kim, M; Cheng, Henrique; Park, S, 2011, Microbial Pathogenesis , Volume: 51, Number: 4, Pages: 297-303
Inflammatory responses to Mycoplasma hyopneumoniae in murine alveolar macrophage cell lines, Dampte, D; Lee, S; Hwang, M; Gebru, E; Choi, M; Lee, J; Cheng, Henrique; Park, S, 2011, New Zealand Veterinary Journal , Volume: 59, Number: 4, Pages: 185-190
In vitro antioxidant activity and anti-inflammatory activities of protoccatechualdehyde isolated from Phellinus gilvus. , Cheng, Henrique, 2011, Journal of Nutritional Science and Vitaminology , Volume: 57, Number: 1, Pages: 118-122
Transient Receptor Proteins illuminated: Current Views on TRPs and Disease., Nelson, Piper; Beck, A; Cheng, Henrique, 2011, The Veterinary Journal , Volume: 187, Number: 2, Pages: 153–164
Mycoplasma hyopneumoniae induces pro-inflammatory cytokine and nitric oxide production through NFκB and MAPK pathways in RAW264.7 cells, Cheng, Henrique, 2011, Veterinary Research Communication , Volume: 35, Number: 1, Pages: 21-34

Book, Textbook Chapter:

Human Stem Cell Therapy, Cheng, Henrique, 2012, Publisher: Wiley-Blackwell, Volume: Chapter 8