Dr. Shafiqul Chowdhury
Professor
Pathobiological Sciences (PBS)
(225) 578-9684

Biography:
Veterinary degree (DVM) and MS in Virology: Bangladesh Agricultural University PhD in virology: Free University of Berlin, Germany

Teaching Interests:
Veterinary Virology, graduate level advanced virology

Research Interests:
Bovine herpesvirus type 1 (BHV-1) and equine herpesvirus type 1 (EHV-1) pathogenesis and genetically engineered vaccines against BHV-1 and EHV-1. BHV-1 as a vaccine vector for immunization against other viral diseases in cattle.

 Awards & Honors:
  • 2015 Excellence in innovation 2015
  • 2015 Zoetis 2015 Research Award
 Grants:
  • Regulation of BoHV-1 maintenance of latency , NIFA/USDA, $490,000.00
  • ovel BHV-1 Vectored Vaccine against Rift Valley fever virus infections in Cattle and Sheep. Total Award Amounts, USDA/NIFA, $500,000.00
  • Pseudorabies virus vectored divalent subunit vaccine against classical swine fever virus and porcine circovirus 2b of pigs, LSU School of Veterinary Medicine, $400,000.00
  • Novel bovine herpesvirus type 1 (BHV-1) vectored vaccine against viral infections associated with bovine respiratory complex (BRDC), LSU School of Veterinary Medicine, $490,000.00
  • Regulation of BHV-1 maintenance of latency, Oklahoma State University, $46,000.00
  • Analysis of BHV-1 VP22 intercellular transport in vitro with or without Us3, NIFA/USDA 1433, $10,000.00
  • Analysis of BHV-1 tegument protein VP22 transport in compartmentalized primary neurons in culture with or without virus infection, USDA, $15,701.00
  • Analysis of BHV-1 tegument protein VP22 transport in compartmentalized primary neurons in culture with or without virus infection, USDA 1433 Formulafunds , $15,000.00
  • Pseudorabies virus vectored trivalent subunit vaccine against classical swine fever virus and porcine circovirus 2b of pigs, Board of Regents, LSU, $46,200.00
  • Novel bovine herpes virus type 1 (BHV-1) vectored vaccine against viral infections associated with bovine respiratory disease complex (BRDC), USDA/NIFA, $493,000.00
  • Pseudorabies virus vectored trivalent subunit vaccine against classical swine fever virus and porcine circovirus 2b of pigs, LSU board of Supervisors LIFT 2 grant program, $47,000.00
  • A superior DIVA vaccine against Bovine herpesvirus type 1, LSU board of Supervisors LIFT 2 grant program, $49,980.00
  • A superior DIVA vaccine against bovine herpesvirus type 1, LSU board of supervisors, $49,980.00
  • Development of a BHV-1 gE Cytoplasmic Tail Based Serological Marker Test , USDA/Formula funds, $17,202.00
  • Construction of a dual gene- deleted (envelope glycoprotein E and thymidine kinase TK-deleted) pseudorabies virus (PRV) expressing classical swine fever envelope protein E2 and porcine circovirus 2b (PCV2b) capsid (CAP) proteins. , CEVA, $350,000.00
 Publications:
Journal Article, Academic Journal:
  • Bovine Herpesvirus 1 U(L)49.5 Interacts with gM and VP22 To Ensure Virus Cell-to-Cell Spread and Virion Incorporation: Novel Role for VP22 in gM-Independent U(L)49.5 Virion Incorporation, Pannhorst, Katrin; Wei, Huiyong; Yezid, Hocine; He, Junyun; Chowdhury, Shafiqul, 2018, JOURNAL OF VIROLOGY , Volume: 92, Number: 13
  • Identification of an epitope within the Bovine herpesvirus 1glycoprotein E cytoplasmic tail and use of a monoclonal antibody directed against the epitope for the differentiation between vaccinated and infected animals. , Chowdhury, Shafiqul, 2016, J. Virological Methods/Elsievier , Volume: 233 , Pages: 97-104
  • A triple gene mutant of BoHV-1 administered intranasally in lambs replicates efficiently in the nasal epithelium and induces neutralizing antibody , Lay, C; Burke, J; Paulsen, Daniel; Chowdhury, Shafiqul, 2016, International Jiournal of Vaccines and Immunization , Volume: 2, Number: 1
  • A triple gene mutant of BoHV-1 adminstered intranasally is significantly more efficacious than a BoHV-1 glycoprotein E-deleted virus against a virulent BoHV-1 challenge , Chowdhury, Shafiqul; Wei, H; Weiss, M; Pannhorst, K; Paulsen, D, 2014, Vaccine/Elsivier , Volume: 32, Number: 39, Pages: 4909-4915
  • Bovine herpesvirus type 1 (BHV-1) mutant lacking U(L)49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induces more rapid onset of virus neutralizing antibody and cellular immune responses in calves than the wild-type strain Cooper. , Paulsen, Daniel; Wei, H; He, J; Chowdhury, Shafiqul, 2012, Vet. Immunol. Immunopathol. , Volume: 16, Number: 6, Pages: 457-465
  • Bovine herpesvirus type 1 (BHV-1) Ul49.5 luminal domain residues 30-32 are critical for MHC-I down-regulation in virus-infected cells. PLOSOne, Chowdhury, Shafiqul; Wei, Huiyong; Wang, Ying, 2011, PLoS One , Volume: 6, Number: 10, Pages: e25742
  • A bovine herpesvirus 5 recombinant defective in the thymidine kinase (TK) gene and a double mutant herpesvirus 5 recombinant defective in the thymidine kinase (TK) gene and a double mutant lacking TK and the glycoprotein E gene are fully attenuated for rabbits. , Chowdhury, Shafiqul; Silva, S.; Brum, Mario; Weiblen, Rudi; Flores, Eduardo, 2010, Brazilian J. Med. Biol. Res. , Volume: 43, Pages: 150-159
  • A bovine herpesvirus type 1 (BHV-1) mutant virus with truncated glycoprotein E cytoplasmic tail has defective anterograde neuronal transport in rabbit dorsal root ganglionic primary neuronal cultures in a microfluidic chamber system, Chowdhury, Shafiqul; Coats, C; Neis, R; Navarro, S.; Paulsen, Daniel; Feng, Ji-Ming, 2010, J. Neurovirology , Volume: 16, Number: 6, Pages: 457-465
  • Bovine herpesvirus type 1 (BHV-1) is an important cofactor in the bovine respiratory disease complex. , Chowdhury, Shafiqul; Jones, Clinton, 2010, Veterinary Clinics of North America: Food Animal Practice , Volume: 26, Pages: 303-321
  • Construction and growth properties of bovine herpesvirus type 5 recombinants defective in the glycoprotein E or thymidine kinase gene or both., Chowdhury, Shafiqul; Brum, Mario; Weiblen, Rudi; Flores, Eduardo, 2010, Brazilian J. Med. Biol. Res. , Volume: 43, Pages: 217-224
  • Immunogenicity of an inactivated bovine herpesvirus type 5 strain defective in the thymidine kinase and glycoprotein E. , Chowdhury, Shafiqul, 2010, Pesq. Vet. Bras. , Volume: 30, Pages: 57-62
Journal Article, Professional Journal:
  • Immunization of bighorn sheep against Mannheimia haemolytica with a bovine herpesvirus 1-vectored vaccine, Batra, Sai; Shanthalingam, Sudavilli; Donofrio, Gaetano; Haldorson, Gary; Chowdhury, Shafiqul; White, Stephen; Srikumaran, Subramaniam, 2017, Vaccine , Volume: 35, Number: 12, Pages: 1630-1636
  • Bovine herpesvirus type 1 (BHV-1) UL49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induce better immune responses in calves than the wild-type strain Cooper , He, Junyun ; Chowdhury, Shafiqul; Wei, Huiyong; Paulsen, Daniel, 2012, Veterinary Immunology and Immunopathology , Volume: 147, Pages: 223-229
  • A recombinant bovine herpesvirus type 5 defective in thymidine kinase and glycoprotein E is immunogenic for calves and confers protection upon homologous challenge and BoHV-1 challenge, Chowdhury, Shafiqul; Anzilliero, D; Santos, C; Brum, M; Weiblen, R; Flores, Eduardo, 2011, Veterinary Microbiology
Cited Research:
  • Bovine herpesvirus vaccine with multiple mutations, Chowdhury, Shafiqul; Wei, Hui, 2013