Dr. Charles Lee
Comparative Biomedical Sciences (CBS)
I was born and raised in Flagstaff, Arizona and graduated as valedictorian from Flagstaff High School. While still in high school, I concurrently attended Northern Arizona University, where I completed the chemistry major requirements and conducted research on photoconductive organic polymer systems. Thereafter, I attended the California Institute of Technology (Caltech), where I was a member of Lloyd House and graduated with honors in chemistry and biology. For graduate school at the University of California at Berkeley, I studied under the mentorship of the late Prof. Jeffery A. Winer. My dissertation focused on the functional organization of convergent neural circuits in the auditory forebrain. Afterwards, I received an NIH Kirschstein NRSA Fellowship to work with Prof. S. Murray Sherman at the University of Chicago, where I was a Research Associate (Assistant Professor). Since 2011, I have been on the faculty at the LSU School of Veterinary Medicine.
I am currently the director of the Year 1 DVM curriculum and also teach and coordinate the Veterinary Neuroscience course (VMED 5171). In addition, I teach in the graduate molecular and cell biology course (CBS 7104) and coordinated the department journal club (CBS 7003). I also produce and host a syndicated science radio program, The Groks Science Show, which is supported in part by a grant from the National Science Foundation. The show is heard locally on WHYR 96.9 FM and nationally through the Public Radio Exchange (PRX).
My laboratory derives neural principles governing the sensory and cognitive functions of the brain using the central auditory system as a model. We investigate the neural circuits and the physiological properties of sensory synapses in the midbrain, thalamus, and cortex by recording electrophysiologically from neurons in response to pharmacological activation, electrical stimulation, optogenetic manipulation, or photostimulation by uncaging of glutamate. Morphological correlates are sought using neuroanatomical methods, such as anterograde and retrograde tract-tracing, cell-type specific viral tracers, and intracellular filling of recorded neurons. From our studies, we wish to elucidate the emergent properties of neuronal ensembles and their roles in regulating behavior.
Our research also addresses how alterations to these central sensory pathways manifest in neurodevelopmental and neurodegenerative disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. Our long-term objectives are to relate aberrant neural circuit organization with the core behavioral deficits observed in these conditions. We expect that this research will illuminate the fundamental roles of these neural networks and their potential as therapeutic targets for these conditions.