Dr. Brent Stanfield
Pathobiological Sciences (PBS)

Biography:
I am a Research Assistant professor in the department of Pathobiological Sciences at Louisiana State University.

Teaching Interests:
During my graduate and postdoctoral training I’ve had the opportunity to mentor high school, undergraduate, graduate, veterinary students, and medical students in the development and pursuit of independent research projects. Many of these students have gone on to continue in research and in the future, I plan to take an active role in mentoring the next generation of academic scientists. This past semester I've had the pleasure to teach the vaccines and vaccinations section of the veterinary immunology class at LSU-SVM.

Research Interests:
My long-term research goals focus on the translational aspects of basic biomedical research. My past research has particularly emphasized the utilization of various animal models to understand the complex relationship between a live attenuated herpes simplex vaccine (VC-2) and the vaccinated host. This work has given me a strong background in herpes virology, immunology, molecular biology and hands on experience with diverse animal models (mouse, guinea pig, rabbit, and primate). My postdoctoral training has expanded my experience as a translational immunologist. In particular my research focuses on understanding the immunomodulatory role histone deacetylases play in the acute immune response to pulmonary infection with gram-negative bacteria. Training in animal models of acute lung injury, bronchial alveolar lavage, surgical techniques, immuno-histology, bacterial genetics, and protein engineering. My current projects aim to understand the tissue specific role of histone deacetylase 3 in the long term expression of SERPINE1 following recovery from acute respiratory distress syndrome/acute lung injury.

 Grants:
  • AM211158, Ximus Biosciences, LLC, $3,857.00
  • LIFT-14A-03, Louisiana State University, $50,000.00
 Publications:
Journal Article, Academic Journal:
  • Acute Respiratory Distress Syndrome (ARDS) after trauma: Improving incidence, but increasing mortality., Kasotakis, G; Stanfield, Brent; Haines, K; Vatsaas, C; Alger, A; Vaslef, S; Brooks, K; Agarwal, S, 2021, Journal of critical care , Volume: 64, Pages: 213-218
  • Bovine versus porcine acellular dermal matrix for abdominal wall herniorrhaphy or bridging., Van Orden, K; Santos, J; Stanfield, Brent; Frost, L; Ruditsky, A; Foster, A; Brahmbhatt, T; Burke, P; Fernandez-Moure, J; Haines, K; Agarwal, S; Kasotakis, G, 2021, European journal of trauma and emergency surgery : official publication of the European Trauma Society
  • IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages., Stanfield, Brent; Purves, T; Palmer, S; Sullenger, B; Welty-Wolf, K; Haines, K; Agarwal, S; Kasotakis, G, 2021, PloS one , Volume: 16, Number: 1, Pages: e0245169
  • Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis., Naidu, S; Nabi, R; Cheemarla, N; Stanfield, Brent; Rider, Paul; Jambunathan, N; Chouljenko, Vladimir; Carter, Renee; Del Piero, Fabio; Langohr, Ingeborg; Kousoulas, Konstantin, 2020, PloS one , Volume: 15, Number: 2, Pages: e0228252
  • Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses., Stanfield, Brent; Rider, Paul; Caskey, J; Del Piero, Fabio; Kousoulas, Konstantin, 2018, Vaccine , Volume: 36, Number: 20, Pages: 2842-2849
  • Recent advances in understanding Epstein-Barr virus., Stanfield, Brent; Luftig, M, 2017, F1000Research , Volume: 6, Pages: 386
  • Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies., Stanfield, Brent; Pahar, B; Chouljenko, Vladimir; Veazey, R; Kousoulas, Konstantin, 2017, Vaccine , Volume: 35, Number: 4, Pages: 536-543
  • A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses., Liu, S; Haque, Muzammel; Stanfield, Brent; Andrews, Frank; Roy, Alma; Kousoulas, Konstantin, 2017, Veterinary microbiology , Volume: 198, Pages: 51-58
  • Bovine herpesvirus type-1 glycoprotein K (gK) interacts with UL20 and is required for infectious virus production., Haque, Muzammel; Stanfield, Brent; Kousoulas, Konstantin, 2016, Virology , Volume: 499, Pages: 156-164
  • Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections., Stanfield, Brent; Kousoulas, Konstantin, 2015, Current clinical microbiology reports , Volume: 2, Number: 3, Pages: 125-136
  • A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains., Stanfield, Brent; Stahl, J; Chouljenko, Vladimir; Subramanian, Ramesh; Charles, A; Saied, A; Walker, J; Kousoulas, Konstantin, 2014, PloS one , Volume: 9, Number: 10, Pages: e109890
  • Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses., Iyer, A; Pahar, B; Chouljenko, V; Walker, J; Stanfield, Brent; Kousoulas, Konstantin, 2013, Virology journal , Volume: 10, Pages: 317
  • Equine herpesvirus type 1-mediated oncolysis of human glioblastoma multiforme cells., Courchesne, M; White, M; Stanfield, Brent; Frampton, Jr, A, 2012, Journal of virology , Volume: 86, Number: 5, Pages: 2882-6