Dr. Britta Leise
Associate Professor
Veterinary Clinical Sciences (VCS)
(225) 578-9500

Research Interests:
Equine Laminitis and conditions of the foot, wound healing, osteoartritis, and inflammatory processes associated with sepsis / SIRS

 Awards & Honors:
  • 2020 Deans Teacher Merit Honor Roll
  • 2020 2nd place poster clinical presentation award
  • 2016 Deans Teacher Merit Honor Roll
 Education:
  • PhD The Ohio State University
  • DVM Louisiana State University
  • MS Louisiana State University
  • BS Virginia Tech
 Grants:
  • Analysis of the Effects of Clodronate Disodium on Equine Articular Cartilage Using an In Vitro Cell Culture Model, Equine Health Studies Program, $4,000.00
  • Cytokine profile in horses administered lipopolysaccharide: Does pentoxifylline have systemic effect on inflammation? , Charles V. Cusimano Equine Health Studies Program Research Grant, $6,000.00
  • Ex Vivo determination of platelet activation via flow cytometry and growth factor production in synovial fluid from osteoarthritic and non-osteoarthritic joints of horses, ACVS Foundation Diplomate Clinical Research Grant, $9,937.00
  • Evaluation of activation of platelet rich plasma in the presence of equine synovial fluid from osteoarthritic joints., Charles V. Cusimano EHSP Research Grant, $5,000.00
  • Evaluation of anti-inflammatory properties and growth factor release after repeated intra-articular injections of leukocyte-poor platelet rich plasma in horses with early-moderate osteoarthritic joints, Charles V. Cusimano EHSP Research Grant, $10,000.00
  • The effect of hyaluronic acid on equine bone marrow-dervied mesenchymal stem cell migration in vitro, LSU-VCS CORP, $4,740.00
  • Assessment of Plasma Adiponectin and Visfatin Concentrations in Horses Administered Lipopolysaccharide and Pentoxifylline, Equine Health Studies Program,
  • mTOR signaling: A potential marker for the assessment of therapeutics for equine laminitis, Equine Health Studies Program, $11,968.00
  • Evaluation of substance P in acute and chronic laminitis, LSU-SVM, NIH Summer Scholar Program, $6,400.00
  • Evaluation of neuropathic pain mediators in acute and chronic laminitis, LSU-SVM Competitive Research Program, USDA 1433, $7,500.00
  • Foal outcomes from mares experiencing colic in the gestational period, LSU-SVM, NIH Summer Scholar Program, $6,200.00
  • Evaluation of anti-inflammatory properties and growth factor release after repeated injections in horses with early-moderate osteoarthritic joints, LSU-VCS CORP, $3,850.00
  • Toxicity assessment of buprenorphine on equine articular chondrocytes in vitro, VCS Corps Grant, $3,985.00
  • Pharmacokinetics and analgesic effect of intra-articular buprenorphine with lipopolysaccharide – induced synovitis in horses., Charles V. Cusimano EHSP grant, $12,000.00
  • Assessment of plasma F-actin and gelsolin concentrations in horses administered lipopolysaccharide and pentoxfylline, Charles V. Cusimano EHSP Research Grant, $12,000.00
  • Immunolocalization and expression of small leucine-rich proteoglycans in models of sepsis related laminitis, LSU-SVM Competitive Research Program , $8,500.00
  • Assessment of keratinocyte wound healing and growth factor production in vitro after exposure to bone marrow derived mesenchymal stem cells or lipopolysaccharide, Charles V. Cusimano EHSP Research Grant, $11,617.00
  • Development of a cervical injection technique in the horse, Charles V. Cusimano EHSP Research Grant, $5,874.00
  • The use of liposomal bupivacaine as an incisional analgesic and its effects on wound healing, LSU-SVM, NIH, Merial Summer Scholar Program, $6,211.00
  • Effects of equine bone marrow derived mesenchymal stem cells on the proinflammatory response of keratinocytes and macrophages exposed to lipopolysaccharide, CSU College Research Council & LSU Departmental Research, $21,481.00
  • Effects of altered weight bearing on digital venous perfusion in horses, LSU-SVM / NIH Summer Scholars Program, $6,094.00
  • Assessment of venograms in performance horses, CSU Young Investigator Grant, $2,920.00
 Publications:
Journal Article, Professional Journal:
  • The effects of bit chewing on borborygmi, duodenal motility, and gastrointestinal transit time in clinically normal horses, Patton, Molly; Baker, Rose; Leise, Britta; Andrews, Frank, 2022, Veterinary Surgery
  • Ex vivo effects of insulin on the structural integrity of equine digital lamellae, Sandow, C; Fugler, L; Leise, Britta; Riggs, Laura; Monroe, T; Totaro, N; Belknap, J; Eades, Susan, 2019, Equine Veterinary Journal , Volume: 51, Number: 1, Pages: 131-135
  • The role of neutrophils in equine laminitis, Leise, Britta, 2018, Cell Tissue Res , Volume: 371, Number: 3, Pages: 541-550
Journal Article, Academic Journal:
  • Laminitis Updates: Sepsis/Systemic Inflammatory Response Syndrome-Associated Laminitis., Leise, Britta; Fugler, L, 2021, The Veterinary clinics of North America. Equine practice , Volume: 37, Number: 3, Pages: 639-656
  • A study of ultrasound-guided perineural injection of the caudal cervical spinal nerve roots in equine cadavers., Cruz-Sanabria, J; Gaschen, Lorrie; Bragulla, Hermann; Mitchell, Mark; Leise, Britta, 2021, Veterinary anaesthesia and analgesia , Volume: 48, Number: 4, Pages: 603-611
  • Apoptosis in epithelial cells and its correlation with leukocyte accumulation in lamellar tissue from horses subjected to experimental sepsis-associated laminitis, Catunda, Antonio; Alves, Geraldo; Leme, Fabiola; Carvalho, Armando; Leise, Britta; Johnson, Philip; Faleiros, Rafael, 2021, Research in Veterinary Science , Volume: 136, Pages: 318-323
  • Pharmacokinetics and pharmacodynamics of clodronate disodium evaluated in plasma, synovial fluid and urine, Krueger, Clarisa; Mitchell, Colin; Leise, Britta; Knych, Heather, 2020, Equine Veterinary Journal
  • Ovarian histopathology, pre- and post-operative endocrinological analysis and behavior alterations in 27 mares undergoing bilateral standing laparoscopic ovariectomy., Devick, I; Leise, Britta; McCue, P; Rao, S; Hendrickson, D, 2020, The Canadian veterinary journal = La revue veterinaire canadienne , Volume: 61, Number: 2, Pages: 181-186
  • Exercising upper respiratory videoendoscopic findings of 50 competition draught horses with abnormal respiratory noise and/or poor performance., Hackett, E; Leise, Britta, 2019, Equine veterinary journal , Volume: 51, Number: 3, Pages: 370-374
  • Enhanced ultrasonographic imaging of the equine distal limb using saline injection of the digital flexor tendon sheath: A cadaver study., Daniel, A; Leise, Britta; Selberg, K; Barrett, M, 2019, Veterinary journal (London, England : 1997) , Volume: 247, Pages: 26-31
  • Venographic evaluation of the circumflex vessels and lamellar circumflex junction in laminitis horses, Kramer, J; Rucker, A; Leise, Britta, 2018, Equine Vet Educ
  • Use of locking compression plate for equine proximal interphalangeal joint arthrodesis: A review of 29 cases (2008-2014), Sakai, R; Goodrich, L; Katzman, S; Moorman, V; Leise, B; Kawcak, C; Galuppo, L, 2018, Journal of the American Veterinary Medical Association , Volume: 253, Number: 11, Pages: 1460-1466
  • Topical Wound Medications., Leise, Britta, 2018, The Veterinary clinics of North America. Equine practice , Volume: 34, Number: 3, Pages: 485-498
  • Evaluation of post-operative pain after active desufflation at completion of laparoscopy in mares undergoing ovariectomy., Devick, I; Leise, Britta; Rao, S; Hendrickson, D, 2018, The Canadian veterinary journal = La revue veterinaire canadienne , Volume: 59, Number: 3, Pages: 261-266
  • Evaluation of two methods for topical medication of contrast medium to the pharyngeal and laryngeal region of horses, Colbath, A; Valdes-Martinez, A; Leise, Britta; Hackett, E, 2017, Amercian Journal of Veterinary Research , Volume: 78, Pages: 1098-1103
  • The effect of hypothermia on influx of mononuclear cells in the digital lamellae of horses with oligofructose-induced laminitis, Goodman, J; Burns, T; Watts, M; Kelly, C; Leise, B; Schoreder, E; Van Eps, A; Belknap, J, 2016, Vet Immunol Immunopathol , Volume: 178, Pages: 22-28
  • Concentrations of serum amyloid A and plasma fibrinogen in horses undergoing emergency abdominal surgery., Daniel, A; Leise, Britta; Burgess, B; Morley, P; Cloninger, M; Hassel, D, 2016, Journal of veterinary emergency and critical care , Volume: 26, Number: 3, Pages: 344-51
  • Use of laser capture microdissection for the assessment of equine lamellar basal epithelial cell signalling in the early stages of laminitis., Leise, Britta; Watts, M; Roy, S; Yilmaz, A; Alder, H; Belknap, J, 2015, Equine veterinary journal , Volume: 47, Number: 4, Pages: 478-88
  • Treatment of intraoperative persistent penile erection in a stallion, Rezende, M; Ferris, Ryan; Leise, Britta; Mama, K; Scofield, D; McCue, P, 2014, Journal of equine veterinary science , Volume: 34, Pages: 431-435
  • Hindlimb laminar inflammatory response is similar to that present in forelimbs after carbohydrate overload in horses., Leise, Britta; Faleiros, R; Watts, M; Johnson, P; Black, S; Belknap, J, 2012, Equine veterinary journal , Volume: 44, Number: 6, Pages: 633-9
  • Laminar regulation of STAT1 and STAT3 in black walnut extract and carbohydrate overload induced models of laminitis., Leise, Britta; Watts, M; Tanhoff, E; Johnson, P; Black, S; Belknap, J, 2012, Journal of veterinary internal medicine / American College of Veterinary Internal Medicine , Volume: 26, Number: 4, Pages: 996-1004
  • Digital hypothermia inhibits early lamellar inflammatory signalling in the oligofructose laminitis model., van Eps, A; Leise, Britta; Watts, M; Pollitt, C; Belknap, J, 2012, Equine veterinary journal , Volume: 44, Number: 2, Pages: 230-7
  • Laminar chemokine mRNA concentrations in horses with carbohydrate overload-induced laminitis., Faleiros, R; Leise, Britta; Watts, M; Johnson, P; Black, S; Belknap, J, 2011, Veterinary immunology and immunopathology , Volume: 144, Number: 1-2, Pages: 45-51
  • Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis., Leise, Britta; Faleiros, R; Watts, M; Johnson, P; Black, S; Belknap, J, 2011, Equine veterinary journal , Volume: 43, Number: 1, Pages: 54-61
  • Proinflammatory cytokine responses of cultured equine keratinocytes to bacterial pathogen-associated molecular pattern motifs., Leise, Britta; Yin, C; Pettigrew, A; Belknap, J, 2010, Equine veterinary journal , Volume: 42, Number: 4, Pages: 294-303
Scientific Abstract:
  • Toxicity assessment of buprenorphine on equine articular chondrocytes in vitro, Castro-Cuellar, Gabriel; Cremer, Jeannette; Queiroz, Patricia; De Caro Carella, Chiara; Leise, Britta, 2020
  • Assessment of digital venograms in non-laminitic horses, Leise, Britta; Miller, Nigel; Moorman, Valerie; Bass, Luke; Pittman, Sammy; Rucker, Amy; Redden, Ric, 2016
Book, Textbook Chapter:
  • Inflammatory Signaling, Leise, Britta, 2016, Publisher:
Regular Column in Journal or Newspaper:
  • Flood Injury in Horses, Walker, Neely; Morton, Courtnee ; McConnico, Rebecca; Leise, Britta; (LA), Rebecca S. McConnico DVM PhD Dipl., 2016