Dr. Alexandra Noël
Assistant Professor
Comparative Biomedical Sciences (CBS)

Research Interests:
The focus of our research is production and characterization of aerosols, composed of engineered nanoparticles, ultrafine or fine particles, as well as inhalation and developmental toxicology. We seek to investigate the fundamental mechanisms at the epigenetic, molecular and cellular levels that underlie the developmental origins of health and disease, with respect to respiratory effects caused by distinct emerging inhaled environmental pollutants. This includes the study of engineered nanoparticles, second-hand smoke, electronic cigarette vapor, hookah smoke, and a multi-pollutant approach to simulate real-life exposure scenarios. We use a multidisciplinary approach bridging inhalation toxicology, nanotoxicology, pathology and lung biology, as well as in utero exposure and lung disease models (asthma, emphysema, fibrosis and lung cancer), coupled with gene expression and DNA methylation analysis, allowing for an adequate exposure – effect continuum correlation. These studies also allow for the identification of the common toxicological pathways and underlying pathophysiological mechanisms related to the adverse pulmonary effects induced by these airborne contaminants.

 Awards & Honors:
  • 2019 Distinguished Scientific Presentation Award - Toxicologists of African Origin, Society of Toxicology
  • 2018 Excellence in Research Grant
  • 2018 Faculty Fellowship Program in Israel - Jewish National Fund
  • 2017 Chair - Gordon Research Seminar (GRS) – Lung Development, Injury & repair
  • 2017 Minority Trainee Development Scholarship - American Thoracic Society
  • 2016 Abstract Scholarship - Thoracic Oncology Assembly, American Thoracic Society
  • 2015 Minority Trainee Development Scholarship - American Thoracic Society
  • 2014 Post-doctoral Fellowship - Fonds de recherche du Québec – Santé
 Education:
  • PhD Université de Montréal, Faculté de Médecine.
  • MSc Université de Montréal, Faculté de Médecine.
  • BS Université de Montréal, Faculté de Médecine.
 Grants:
  • Effect of third-generation electronic cigarette design features on aerosol constituents and pulmonary toxicity in vitro and in vivo, NIH/FDA, $146,695.00
  • In utero second-hand smoke, adult emphysema and inhaled vitamin D therapy, LSU SVM, $10,000.00
 Publications:
Journal Article, Academic Journal:
  • Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies, Noel, Alexandra; Verret, Christina; Hasan, Farhana; Lomnicki, Slawomir; Morse, John; Robichaud, Annette; Penn, Arthur, 2018, Journal of Visualized Experiments , Volume: 138, Pages: e58095
  • Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero, Noel, A; Xiao, R; Perveen, Z; Zaman, H; Le Donne, V; Penn, Arthur, 2017, Respiratory Research , Volume: 18: 104
  • Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease, Lewis, B; Sultana, R; Sharma, R; Noel, Alexandra; Langohr, Ingeborg; Patial, Sonika; Penn, Arthur; Saini, Yogesh, 2017, Journal of Immunology , Volume: 199, Number: 3, Pages: 1170-1183
  • Characterization of Aerosols of Titanium Dioxide Nanoparticles Following Three Generation Methods Using an Optimized Aerosolization System Designed for Experimental Inhalation Studies, Pujalté, Igor ; Serventi, Alessandra; Noel, Alexandra; Dieme, Denis; Haddad, Sami; Bouchard, Michèle, 2017, Toxics , Volume: 5, Number: 3, Pages: 14
  • Mass or total surface area with aerosol size distribution as exposure metrics for inflammatory, cytotoxic and oxidative lung responses in rats exposed to titanium dioxide nanoparticles., Noel, Alexandra; Truchon, G; Cloutier, Y; Charbonneau, M; Maghni, K; Tardif, R, 2017, Toxicology and industrial health , Volume: 33, Number: 4, Pages: 351-364
  • In utero exposure to second-hand smoke activates pro-asthmatic and oncogenic miRNAs in adult asthmatic mice, Xiao, R; Noel, A; Perveen, Z; Penn, Arthur, 2016, Environmental and Molecular Mutagenesis , Volume: 57, Number: 3, Pages: 190-199
  • Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice, Noel, A; Xiao, R; Perveen, Z; Zaman, H; Rouse, R; Paulsen, D; Penn, Arthur, 2016, Particle and Fibre Toxicology , Volume: 13: 10
  • Inhaled titanium dioxide nanoparticles: a review of their pulmonary responses with particular focus on the agglomeration state, Noel, Alexandra; Truchon, Ginette, 2014, Nano LIFE , Volume: 4, Pages: 21
  • Advancement in Quebec research on the prevention of risks related to occupational exposure to nanomaterials., Dolez, Patricia; Coutier, Yves; Noel, Alexandra; Tabet, Lyes; Gautrin, Denise; Debia, Maximilien; L'Esperance, Gilles; Halle, Stephane; Bahloul, Ali; Vinches, Ludovic, 2013, Relations Industrielles / Industrial Relations , Volume: 68, Number: 4, Pages: 623-642
  • Rat pulmonary responses to inhaled nano-TiO₂: effect of primary particle size and agglomeration state., Noel, Alexandra; Charbonneau, M; Cloutier, Y; Tardif, R; Truchon, G, 2013, Particle and fibre toxicology , Volume: 10, Pages: 48
  • Assessment of the contribution of electron microscopy to nanoparticle characterization sampled with two cascade impactors., Noel, Alexandra; L'Espérance, G; Cloutier, Y; Plamondon, P; Boucher, J; Philippe, S; Dion, C; Truchon, G; Zayed, J, 2013, Journal of occupational and environmental hygiene , Volume: 10, Number: 3, Pages: 155-72
  • Generating nano-aerosols from TiO₂ (5 nm) nanoparticles showing different agglomeration states. Application to toxicological studies., Noel, Alexandra; Cloutier, Y; Wilkinson, K; Dion, C; Hallé, S; Maghni, K; Tardif, R; Truchon, G, 2013, Journal of occupational and environmental hygiene , Volume: 10, Number: 2, Pages: 86-96
  • Effects of inhaled nano-TiO2 aerosols showing two distinct agglomeration states on rat lungs., Noel, Alexandra; Maghni, K; Cloutier, Y; Dion, C; Wilkinson, K; Hallé, S; Tardif, R; Truchon, G, 2012, Toxicology letters , Volume: 214, Number: 2, Pages: 109-19
  • Impact of emerging pollutants on pulmonary inflammation in asthmatic rats: ethanol vapors and agglomerated TiO2 nanoparticles., Scarino, A; Noel, Alexandra; Renzi, P; Cloutier, Y; Vincent, R; Truchon, G; Tardif, R; Charbonneau, M, 2012, Inhalation toxicology , Volume: 24, Number: 8, Pages: 528-38
  • Impact of two particle measurement techniques on the determination of N95 class respirator filtration performance against ultrafine particles., Mostofi, R; Noel, Alexandra; Haghighat, F; Bahloul, A; Lara, J; Cloutier, Y, 2012, Journal of hazardous materials , Volume: 217-218, Pages: 51-7